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Publications

Guo Y., Walther T.C., Rao M., Stuurman N., Goshima G., Terayama K.,Wong J., Vale R.D., Walter P. & Farese1 R.V.. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 2008 453: 657-661.

Yen CL, Stone SJ, Koliwad S, Harris C, Farese RV Jr. DGAT enzymes and triacylglycerol biosynthesis. J Lipid Res. 2008 Aug 29.

Minehira K., Young S.G., Villanueva C.J., Yetukuri L., Oresic M., Hellerstein M.K., Farese R.V. Jr, Horton J.D., Preitner F., Thorens B., Tappy L. Blocking VLDL secretion causes hepatic steatosis but does not affect peripheral lipid stores or insulin sensitivity in mice. J Lipid Res. 2008 Sep;49(9):2038-44.

Levin M.C., Monetti M., Watt M.J., Sajan M.P., Stevens, R.D., Bain J.R., Newgard C.B., Farese R.V Sr. and Farese R.V Jr. Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am J Physiol Endocrinol Metab 2007 293: E1772–E1781.

Chan L.C., Peters W., Xu Y., Chun J., Farese R.V Jr, Cases S. LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J Leukoc Biol. 2007 Nov;82(5):1193-200.

Monetti M, Levin MC, Watt MJ, Sajan MP, Marmor S, Hubbard BK, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Hevener AL, Farese RV Jr. Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. Cell Metabolism. 2007 Jul;6(1):69-78

Stone S.J., Levin M.C., Farese RV Jr. Membrane topology and identification of key functional amino acid residues of murine acyl-CoA:diacylglycerol acyltransferase-2. J Biol Chem. 2006 Dec 29;281(52):40273-82.

Feldman B.J., Streeper R.S., Farese R.V Jr, Yamamoto K.R. Myostatin modulates adipogenesis to generate adipocytes with favorable metabolic effects. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15675-80.

Millar, J.S., Stone, S.J., Tietge, U.J., Tow, B., Billheimer, J.T., Wong, J.S., Hamilton, R.L., Farese, R.V., Jr, Rader DJ. Short-term hepatic overexpression of DGAT1 or DGAT2 in female mice increases hepatic triglyceride synthesis without changing VLDL triglyceride or ApoB production. J Lipid Res. 2006 Oct;47(10):2297-305

Farese, R.V., Jr. "Editorial: The Nine Lives of ACAT Inhibitors." Arterioscler. Thromb. Vasc. Biol. 2006 26:1684-1686.

Rudel, L. L. and Farese, R.V., Jr. ACAT inhibition and the progression of coronary atherosclerosis. N Engl J Med. 2006 354:2616-2617.

Yen, C.-L.E., and Farese, R.V., Jr. Fat breakdown: A function for CGI-58 (ABHD5) provides a new piece of the puzzle. Cell Metab. 2006 3:305-307.

Streeper R, Koliwad SK, Villaneuva CJ, Farese RV Jr. Effects of DGAT1 deficiency on energy and glucose metabolism are independent of adiponectin. Am. J. Physiol. 2006 291:388-394.

Yen CL, Monetti M, Burri BJ, Farese RV Jr The triacylglycerol synthesis enzyme DGAT1 also catalyzes the synthesis of diacylglycerols, waxes, and retinyl esters. J. Lipid Res. 2005 46:1502–1511.

Yen CL, Brown CH 4th, Monetti M, Farese RV Jr A human skin multifunctional O-acyltransferase that catalyzes the synthesis of acylglycerols, waxes, and retinyl esters. J. Lipid Res. 2005 46:2388–2397.

Chen, H.C. and Farese, R.V., Jr. Inhibition of triglyceride synthesis as a treatment strategy for obesity: Lessons from DGAT1-deficient mice. Arterioscler. Thromb. Vasc. Biol. 2005 25:482–486.

Repa, J.J., Buhman, K.K., Farese, R.V., Jr., Dietschy, J.M., and Turley, S.D. ACAT2 deficiency limits cholesterol absorption in cholesterol-fed mice: Impact on hepatic cholesterol homeostasis. Hepatology. 2004 40:1088-1097.

Cases, S., Zhou, P., Shillingford, J.M., Wiseman, B.S., Fish, J.D., Angle, C.S., Hennighausen, L., Werb, Z., and Farese, R.V., Jr. Development of the mammary gland requires DGAT1 expression in stromal and epithelial tissues. Development 2004 131:3047–3055.

Chen, H.C., Rao, M., Sajan, M.P., Standaert, M., Kanoh, Y., Miura , A., Farese, R.V., Jr., and Farese, R.V. The role of adipocyte-derived factors in enhancing insulin signaling in ske letal muscle and white adipose tissue of mice lacking acyl coenzyme A:diacylglycerol acyltransferase 1. Diabetes 2004 53:1445–1451.

Stone, S., Myers, H.M., Brown, B., Watkins, S. , Feingold K., Elias P., and Farese, R.V., Jr. Lipopenia and skin barrier abnormalities in DGAT2-deficient mice. J. Biol. Chem. 2004 279:11767-11776.

Listenberger, L.L., Han, X., Lewis, S.E., Cases, S., Farese, R.V., Jr., Ory, D.S., and Schaffer, J.E. Triglyceride accumulation protects against fatty acid-induced lipotoxicity. Proc. Natl. Acad. Sci. USA 2003 100:3077-3082.

Chen, H.C., Jensen, D.R., Myers, H.M., Eckel, R.H., Farese, R.V., Jr. Obesity resistance and enhanced glucose metabolism in mice transplanted with white adipose tissue lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 2003 111:1715-1722.

Yen, C.-L.E., Farese, R.V., Jr. MGAT2, a monoacylglycerol acyltransferase expressed in the small intestine. J. Biol. Chem. 2003 278:18532-18537.

Willner, E.L., Tow, B., Buhman, K.K., Wilson, M., Sanan, D.A., Rudel, L.L., Farese, R.V., Jr. Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient mice. Proc. Natl. Acad. Sci. USA 100:1262-1267. 2003

Chen, H.C., Ladha, Z., Smith, S.J., Farese, R.V., Jr. Analysis of energy expenditure at different ambient temperatures in mice lacking acyl coenzyme A:diacylglycerol acyltransferase 1. Am. J. Physiol. Endocrinol. Metab. 2003 284:E213-E218.

Ludwig, E.H., Mahley, R.W., Palaoglu, E., Balestra, M.E., Borecki, I.B., Innerarity, T.L., and Farese, R.V., Jr. DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin. Genet. 2002 62:68-73.

Chen, H.C. and Farese, R.V., Jr. Determination of adipocyte size by computer image analysis. J. Lipid Res. 2002 43:986-989.

Chen, H.C., Stone, S.J., Zhou, P., Buhman, K.K., and Farese, R.V., Jr. Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl CoA:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes. 2002 51:3189-3195.

Chen, H.C., Ladha, Z. and Farese, R.V., Jr. Deficiency of acyl CoA:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology. 2002 143:2893–2899.

Chen, H.C. and Farese, R.V., Jr. Fatty acids, triglycerides, and glucose metabolism: Recent insights from knockout mice. Curr. Opin. Clin. Nutr. Metab. Care. 2002 5:359–363.

Buhman, K.K., Smith, S.J., Stone, S.J., Repa, J.J., Wong, J.S., Knapp, F.F., Jr., Burri, B.J., Hamilton, R.L., Abumrad, N.A., and Farese, R.V., Jr. DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J. Biol. Chem. 2002 277:25474–25479.

Yen, C.-L.E, Stone, S.J., Cases, S., Zhou, P., and Farese, R.V., Jr. Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc. Natl. Acad. Sci. USA 2002 99:8512–8517.

Chen, H.C., Smith, S.J., Ladha, Z., Jensen, D.R., Ferreira, L.D., Pulawa, L.K., McGuire, J.G., Pitas, R.E., Eckel, R.H., and Farese, R.V., Jr. Increased insulin and leptin sensitivity in mice lacking acyl CoA:diacylglycerol acyltransferase 1. J. Clin. Invest. 2002 109:1049–1055.

Chen, H.C., Smith, S.J., Tow, B., Elias, P.M., and Farese, R.V., Jr. Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J. Clin. Invest. 2002 109:175–181.

Fazio, S., Major, A.S., Swift, L.L., Gleaves, L.A., Accad, M., Linton, M.F., and Farese, R.V., Jr. Increased atherosclerosis in LDL receptor-null mice lacking ACAT1 in macrophages. J. Clin. Invest. 2001 107:163-171.

Sonda, S., Ting, L.-M., Novak, S., Kim, K., Maher, J.J., Farese, R.V., Jr., and Ernst, J.D. Cholesterol esterification by host and parasite is essential for optimal proliferation of Toxoplasma gondii. J. Biol. Chem. 2001 276:34434-34440.

Buhman, K.K., Chen, H.C., and Farese, R.V., Jr. The enzymes of neutral lipid synthesis. J. Biol. Chem. 2001 276:40369–72.

Cases, S., Stone, S.J., Zhou, P., Yen, E., Tow, B., Lardizabal, K.D., Voelker, T., and Farese, R.V., Jr. Cloning of DGAT2, a second mammalian diacylglycerol acyltransferase, and related family members. J. Biol. Chem. 2001 276:38870–38876.

Chen, H. and Farese, R.V., Jr. DGAT and triglyceride synthesis: A new target for obesity treatment? Trends Cardiovasc. Med. 2001 10:188–192.

Accad, M., Smith, S.J., Newland, D., Sanan, D., King, L.E., Jr., Linton, M.F., Fazio, S., and Farese, R.V., Jr. Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking ACAT1. J. Clin. Invest. 2000 105:711-719.

Buhman, K.K., Choi, R.S., Accad, M., Novak, S., Wong, J.S., Hamilton, R.L., Farese, R.V., Jr. Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat. Med. 2000 6:1341–1347.

Terasawa, Y., Ladha, Z., Leonard, S., Morrow, J.D., Newland, D., Sanan, D., Packer, L., Traber, M.G., Farese, R.V., Jr. Increased atherosclerosis in hyperlipidemic mice deficient in a-tocopherol transfer protein and vitamin E. 2000 Proc. Natl. Acad. Sci. USA 97:13830–13834.

Buhman, K.K., Accad, M., and Farese, R.V., Jr. Mammalian acyl CoA:cholesterol acyltransferases. Biochim. Biophys. Acta, K. Bloch Special Issue, 2000 1529:142–154.

Farese, R.V., Jr., Cases, S., and Smith, S.J. Trigyceride synthesis: insights from the cloning of DGAT. Curr. Opin. Lipidol. 2000 11:229–234.

Smith, S.J., Cases, S., Jensen, D.R., Sande, E., Tow, B., Sanan, D., Raber, J., Eckel, R.H., Farese, R.V., Jr. Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking DGAT. Nat. Genet. 2000 25:87–90.

Cases, S., Smith, S.J., Zheng, Y.-W., Myers, H.M., Lear, S.R., Sande, E., Novak, S., Collins, C., Welch, C.B., Lusis, A.J., Erickson, S.K., and Farese, R.V., Jr. Identification of a gene encoding an acyl CoA:diacylglycerol acyltransferase, a key enzyme in triacylglycerol synthesis. Proc. Natl. Acad. Sci. USA 1998 95:13018–13023.

Cases, S.C., Novak, S., Zheng, Y.-W., Myers, H.M., Lear, S.R., Sande, E., Welch, C.B., Lusis, A.J., Spencer, T.A., Krause, B.R., Erickson, S.E., and Farese, R.V., Jr. ACAT-2, a second mammalian acyl CoA:cholesterol acyltransferase: Its cloning, expression, and characterization. J. Biol. Chem. 1998 273:26755–26764.

Farese, R.V., Jr. Acyl CoA:cholesterol acyltransferase (ACAT) genes and knockout mice. Curr. Opin. Lipidol. 1998 9:119–123.

Meiner, V., Tam, C., Gunn, M.D., Dong, L.-M., Weisgraber, K.H., Novak, S., Myers, H.M., Erickson, S.K., and Farese, R.V., Jr. (1997) Tissue expression studies of mouse acyl CoA:cholesterol acyltransferase gene: Findings supporting the existence of multiple cholesterol esterification enzymes in mice. J. Lipid Res. 38:1928–1933.

Meiner, V.L., Cases, S., Myers, H.M., Sande, E.R., Bellosta, S., Schambelan, M., Pitas, R.E, McGuire, J., Herz, J., Farese, R.V., Jr. (1996) Disruption of the acyl CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc. Nat. Acad. Sci. USA 93:14041–14046.

Farese, R.V., Jr., Cases, S., Ruland, S.L., Kayden, H.J., Wong, J.S., Young, S.G., and Hamilton, R.L. (1996) A novel function for apolipoprotein B: Lipoprotein synthesis in the yolk sac is critical for maternal-fetal lipid transport in mice. J. Lipid Res. 37:347–360.

Farese, R.V., Jr., Ruland, S.L., Flynn, L.M., Stokowski, R.P., and Young, S.G. (1995) Knockout of the mouse apolipoprotein B gene results in embryonic lethality in homozygotes and protection against diet-induced hypercholesterolemia in heterozygotes. Proc. Natl. Acad. Sci. USA 92:1774–1778.