The major research goal of our laboratory is to understand the molecular mechanisms that underlie neurodegenerative disorders associated
with protein misfolding, focusing on Alzheimer’s disease, Huntington’s disease
and Parkinson’s disease. We utilize a broad array of tools and methods in our studies,
including structural analyses of misfolded proteins and their assembly into aggregates,
yeast genetic and chemical-genetic screens to identify proteins and small molecules that
modulate aggregation and toxicity of disease-causing proteins, and molecular genetic and
pharmacological approaches in cellular and animal models of protein misfolding and
neurodegeneration. Our long-term goal is to use information gained from basic science,
mechanism-based approaches to identify novel therapeutic targets for small molecules
that could prevent neurodegeneration in humans.
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