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Publications
2011
Daniel Zwilling,
Shao-Yi
Huang,
Korrapati V. Sathyasaikumar,
Francesca M. Notarangelo,
Paolo Guidetti, Hui-Qiu Wu,
Jason Lee,
Jennifer Truong,
Yaisa Andrews-Zwilling,
Eric W. Hsieh,
Jamie Y. Louie,
Tiffany Wu, Kimberly
Scearce-Levie,
Christina Patrick,
Anthony Adame,
Flaviano Giorgini,
Saliha Moussaoui,
Grit Laue, Arash Rassoulpour,
Gunnar Flik,
Yadong Huang,
Joseph M. Muchowski,
Eliezer Masliah,
Robert Schwarcz, and Paul J.
Muchowski, "Kynurenine 3-Monooxygenase
Inhibition in Blood Ameliorates Neurodegeneration"
(Full
Text)
Peter H. Reinhart
and Jeffery W. Kelly,
"Treating
the Periphery to Ameliorate Neurodegenerative Diseases",
Cell 145, June 10, 2011.
(Full Text)
Xuesong Chen,
Jun Wu,
Yuan Luo,
Xia Liang,
Charlene Supnet,
Mee Whi Kim,
Gregor P. Lotz,
Guocheng Yang,, Paul J. Muchowski,
Thomas Kodadek,
and Ilya Bezprozvanny, "Expanded Polyglutamine-Binding
Peptoid as a Novel Therapeutic Agent for Treatment of Huntington’s
Disease", (Full Text)
Jason Miller, Montserrat Arrasate,
Elizabeth Brooks, Clare Peters Libeu, Justin Legleiter, Danny
Hatters, Jessica Curtis, Kenneth Cheung, Preethi Krishnan,
Siddhartha Mitra, Kartika Widjaja, Benjamin AShaby, Gregor PLotz,
Yvonne Newhouse, Emily J Mitchell, Alex Osmand, Michelle Gray,
Vanitha Thulasiramin, Frédéric Saudou, Mark Segal, X William Yang,
Eliezer Masliah, Leslie M Thompson, Paul J Muchowski, Karl H
Weisgraber & Steven Finkbeiner, "Identifying polyglutamine protein
species in situ that best predict neurodegeneration",
National Chemical Biology,
published online: 30
october 2011 | doi: 10.1038/NChemBio.694.
(Full Text)
2010
Eran Tauber, Leonor Miller-Fleming,
Robert P. Mason, Wanda Kwan, Jannine Clapp, Nicola J. Butler, Tiago
F. Outeiro, Paul J. Muchowski, and Flaviano Giorgini, "Functional
Gene Expression Profiling in Yeast Implicates Translational
Dysfunction in Mutant Huntingtin Toxicity",
(Full Text)
Gregor P. Lotz, Justin Legleiter, Rebecca Aron,
Emily J. Mitchell, Shao-Yi Huang, Cheping Ng, Charles Glabe, Leslie
M. Thompson, and Paul J. Muchowski, "Hsp70 and Hsp40 Functionally
Interact with Soluble Mutant Huntingtin Oligomers in a Classic
ATP-dependent Reaction Cycle",
(Full
Text)
Robert
Schwarcz, Paolo Guidetti, Korrapati V. Sathyasaikumar, Paul J.
Muchowski, "Of mice, rats and men: Revisiting the quinolinic acid
hypothesis of Huntington’s disease", Progress in
Neurobiology, Special Issue Chemical Signaling in the Nervous
System in Health and Disease: Nils-Ake Hillarp's Legacy, published
by Elsevier.
(Full Text)
2009
Sathasivam K, Lane A, Legleiter J, Warley A, Woodman B, Finkbeiner S, Paganetti P, Muchowski PJ, Wilson S, Bates GP., "Identical oligomeric and fibrillar structures captured from the brains of R6/2 and knock-in mouse models of Huntington's disease", Hum. Mol Genet.,(2009). (Full Text)
Miller J, Rutenber E, Muchowski PJ., "Polyglutamine dances the conformational cha-cha-cha.", Structure, 17(9):1151-3(2009). (Full
Text)
Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ., "Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease.", J. Neurosci., 29(28):9104-14 (2009). (Full
Text)
Muccioli GG, Sia A, Muchowski PJ, Stella N.,
"Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae.", PLoS One, 4(6):e5942. (2009). (Full
Text)
Giorgini F, Muchowski PJ., "Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease.", Methods Mol. Biol.,, 548:161-74 (2009). (Full
Text)
Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ., "Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment.", J. Neurosci., 284(32):21647-58 (2009).
(Full
Text)
Salazar L, Kashiwada T, Krejci P, Muchowski P, Donoghue D, Wilcox WR, Thompson LM., "A novel interaction between fibroblast growth factor receptor 3 and the p85 subunit of phosphoinositide 3-kinase: activation-dependent regulation of ERK by p85 in multiple myeloma cells.", J. Biol. Chem.,, 284(32):21647-58 (2009). (Full
Text)
2008
Trinh, K., Moore, K., Wes, P.D., Muchowski, P.J., Dey, J., Andrews, L., Pallanck, L.J., "Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease", J. Neurosci., 28: 465-472 (2008).
(Full Text)
Muchwoski, P.J., Ramsden, R., Nguyen, Q., Arnett, E.E., Greiling, T.M., Anderson, S.K., Clark, J.I., "Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens", J. Biol. Chem., 283: 6330-6336 (2008). (Full
Text)
Giorgini, F., Moller, T., Kwan, W., Zwilling, D., Wacker, J.L., Hong, S., Tsai, L.C., Cheah, C.S., Schwarcz, R., Guidetti, P., Muchowski, P.J. "Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment", J. Biol. Chem., 283: 7390-7400 (2008).
(Full
Text)
2007
Irene H. Cheng ,
Kimberly Scearce-Levie, Justin Legleiter, Jorge J. Palop, Hilary
Gerstein, Nga Bien-Ly, Jukka Puoliva¨ li, Sylvain Lesne´ , Karen H.
Ashe, Paul J. Muchowski, and Lennart Mucke, "Accelerating
Amyloid-Fibrillization Reduces Oligomer
Levels and Functional Deficits in
Alzheimer Disease Mouse Models, From the Gladstone
Institute of Neurological Disease, San Francisco, California
94158, the Departments of Neurology and Biochemistry and Biophysics,
University of California, San Francisco, California 94143, and the
Department of Neurology, University of Minnesota Medical School,
Minneapolis, Minnesota 55455
(Full
Text)
Cheng, I.H.,
Scearce-Levie, K., Legleiter, J., Palop, J.J., Gerstein, H., Nga,
B.L., Puoliväli, J., Lesné, S., Ashe, K.H., Muchowski, P.J., and
Mucke, L., “Enhancing the fibrillization and deposition of the
amyloid-b peptide reduces its negative impact on behavior and
synaptic activity-dependent proteins”, J. Biol. Chem.,
282:23818-23828 (2007).
(Full Text)
Rosser, M.F.N., Muchowski, P.J., Patterson, C. and Cyr, D.M.,
“Chaperone Functions of the E3 Ubiquitin Ligase CHIP”, J.
Biol. Chem., 282:22267-22277 (2007).
(Full Text)
2006
Dagmar E. Ehrnhoefer, Martin Duennwald, Phoebe
Markovic, Jennifer L. Wacker, Sabine Engemann, Margaret Roark,
Justin Legleiter, J. Lawrence Marsh, Leslie M. Thompson, Susan
Lindquist, Paul J. Muchowski and Erich E. Wanker. "Green tea
(2)-epigallocatechin-gallate modulates early events in huntingtin
misfolding and reduces toxicity in Huntington’s disease models",
Human Molecular Genetics, 2006, Vol. 15, No. 18 2743–2751
(Full Text)
Giorgini, F. and Muchowski, P.J., “Screening
for genetic modifiers of amyloid toxicity in yeast”, Methods
Enzymol., 412:201-22 (2006).
(Full
Text)
Finkbeiner, S., Cuervo, A.M., Morimoto, R.I.
and Muchowski, P.J., “Disease-modifying pathways in
neurodegeneration”, J. Neurosci., 26:10349-57 (2006). (Full
Text)
Duennwald, M., Jagadish, S., Muchowski, P.J.
and Lindquist, S., “Flanking sequences profoundly alter
polyglutamine toxicity in yeast”, Proc. Natl. Acad. Sci.
U.S.A., 103:11,045-11,050, 2006.
(Full Text)
Duennwald, M., Jagadish, S., Giorgini, F.,
Muchowski, P.J. and Lindquist, S., “A network of protein
interactions determines polyglutamine toxicity”, Proc. Natl.
Acad. Sci. U.S.A., 103:11,051-11,056, 2006.
(Full Text)
2005
Giorgini, F., Guidetti, P., Nguyen, Q.V.,
Bennett, S.C. and Muchowski, P.J., “A genomic screen in yeast
implicates kynurenine 3-monooxygenase as a therapeutic target for
Huntington’s disease”, Nature Genetics, 37:526-531,
2005. (Full Text)
Giorgini, F. and Muchowski, P.J., “Connecting
the dots in Huntington’s disease: exploiting protein interaction
networks”, Genome Biology, 6:210, 2005.
(Full
Text)
Muchowski, P.J. and Wacker, J.L., “Modulation
of neurodegeneration by molecular chaperones” Nat. Rev.
Neurosci., 6:11-22, 2005.
(Full
Text)
2004
Wacker, J.L.,
Zareie, M.H., Fong, H., Sarikaya, M. and Muchowski, P.J., “Hsp70 and
Hsp40 attenuate formation of spherical and annular polyglutamine
oligomers by partitioning monomer”, Nat. Struct. and Mol.
Biol., 11:1101-1106, 2004. (Full
Text)
Tiago Fleming Outeiro ,1
and Paul J. Muchowski, "Molecular
Genetics Approaches in Yeast to Study Amyloid Diseases",
Journal of Molecular Neuroscience
Review Article Volume
23 Nos. 1–2, 2004. (Full
Text)
2003
Willingham, S., Outeiro, T.F., DeVit, M.J.,
Lindquist, S.L. and Muchowski, P.J., “Yeast genes that enhance the
toxicity of a mutant huntingtin fragment or
a-synuclein”, Science,
302:1769-1772,
2003.
(Full Text)
2002
Muchowski, P.J., “Protein misfolding, amyloid
formation and neurodegeneration: A critical role for molecular
chaperones?”, Neuron, 35:9-12, 2002.
(Full Text)
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