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Publications
2008
Trinh, K., Moore, K., Wes, P.D., Muchowski, P.J., Dey, J., Andrews, L., Pallanck, L.J., "Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease", J. Neurosci., 28: 465-472 (2008). (Full
Text)
Muchwoski, P.J., Ramsden, R., Nguyen, Q., Arnett, E.E., Greiling, T.M., Anderson, S.K., Clark, J.I., "Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens", J. Biol. Chem., 283: 6330-6336 (2008). (Full
Text)
Giorgini, F., Moller, T., Kwan, W., Zwilling, D., Wacker, J.L., Hong, S., Tsai, L.C., Cheah, C.S., Schwarcz, R., Guidetti, P., Muchowski, P.J. "Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment", J. Biol. Chem., 283: 7390-7400 (2008). (Full
Text)
2007
Cheng, I.H.,
Scearce-Levie, K., Legleiter, J., Palop, J.J., Gerstein, H., Nga,
B.L., Puoliväli, J., Lesné, S., Ashe, K.H., Muchowski, P.J., and
Mucke, L., “Enhancing the fibrillization and deposition of the
amyloid-b peptide reduces its negative impact on behavior and
synaptic activity-dependent proteins”, J. Biol. Chem.,
282:23818-23828 (2007).
(Full Text)
Rosser, M.F.N., Muchowski, P.J., Patterson, C. and Cyr, D.M.,
“Chaperone Functions of the E3 Ubiquitin Ligase CHIP”, J.
Biol. Chem., 282:22267-22277 (2007).
(Full Text)
2006
Giorgini, F. and Muchowski, P.J., “Screening
for genetic modifiers of amyloid toxicity in yeast”, Methods
Enzymol., 412:201-22 (2006).
(Full
Text)
Finkbeiner, S., Cuervo, A.M., Morimoto, R.I.
and Muchowski, P.J., “Disease-modifying pathways in
neurodegeneration”, J. Neurosci., 26:10349-57 (2006).(Full
Text)
Ehrnhoefer, D.E., Duennwald, M., Markovic, P.,
Wacker, J.L., Engemann, S., Roark, M., Legleiter, J.L., Marsh, J.L.,
Thompson, L.M., Lindquist, S., Muchowski, P.J. and Wanker, E.E.,
“Green tea (-)-epigallocatechin-gallate modulates huntingtin
misfolding and reduces toxicity in Huntington’s disease models”,
Hum. Mol. Genet., 15: 2743-2751 (2006).
Full Text)
Duennwald, M., Jagadish, S., Muchowski, P.J.
and Lindquist, S., “Flanking sequences profoundly alter
polyglutamine toxicity in yeast”, Proc. Natl. Acad. Sci.
U.S.A., 103:11,045-11,050, 2006.
Full Text
Duennwald, M., Jagadish, S., Giorgini, F.,
Muchowski, P.J. and Lindquist, S., “A network of protein
interactions determines polyglutamine toxicity”, Proc. Natl.
Acad. Sci. U.S.A., 103:11,051-11,056, 2006.
Full Text
2005
Giorgini, F., Guidetti, P., Nguyen, Q.V.,
Bennett, S.C. and Muchowski, P.J., “A genomic screen in yeast
implicates kynurenine 3-monooxygenase as a therapeutic target for
Huntington’s disease”, Nature Genetics, 37:526-531,
2005. (Full Text)
Giorgini, F. and Muchowski, P.J., “Connecting
the dots in Huntington’s disease: exploiting protein interaction
networks”, Genome Biology, 6:210, 2005.
(Full
Text)
Muchowski, P.J. and Wacker, J.L., “Modulation
of neurodegeneration by molecular chaperones” Nat. Rev.
Neurosci., 6:11-22, 2005.
(Full
Text)
2004
Wacker, J.L.,
Zareie, M.H., Fong, H., Sarikaya, M. and Muchowski, P.J., “Hsp70 and
Hsp40 attenuate formation of spherical and annular polyglutamine
oligomers by partitioning monomer”, Nat. Struct. and Mol.
Biol., 11:1101-1106, 2004. (Full
Text)
Outeiro, T.F. and Muchowski, P.J., “Molecular
genetics approaches in yeast to study amyloid diseases”, J.
Mol. Neurosci., 23:49-60, 2004.
(Full
Text)
2003
Willingham, S., Outeiro, T.F., DeVit, M.J.,
Lindquist, S.L. and Muchowski, P.J., “Yeast genes that enhance the
toxicity of a mutant huntingtin fragment or
a-synuclein”, Science,
302:1769-1772,
2003.
(Abstract)
(Full Text)
2002
Muchowski, P.J., “Protein misfolding, amyloid
formation and neurodegeneration: A critical role for molecular
chaperones?”, Neuron, 35:9-12, 2002. (Abstract)
(Full Text)
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