Publications

2008

Trinh, K., Moore, K., Wes, P.D., Muchowski, P.J., Dey, J., Andrews, L., Pallanck, L.J., "Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease", J. Neurosci., 28: 465-472 (2008). (Full Text)

Muchwoski, P.J., Ramsden, R., Nguyen, Q., Arnett, E.E., Greiling, T.M., Anderson, S.K., Clark, J.I., "Noninvasive measurement of protein aggregation by mutant huntingtin fragments or alpha-synuclein in the lens", J. Biol. Chem., 283: 6330-6336 (2008). (Full Text)

Giorgini, F., Moller, T., Kwan, W., Zwilling, D., Wacker, J.L., Hong, S., Tsai, L.C., Cheah, C.S., Schwarcz, R., Guidetti, P., Muchowski, P.J. "Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment", J. Biol. Chem., 283: 7390-7400 (2008). (Full Text)

2007

Cheng, I.H., Scearce-Levie, K., Legleiter, J., Palop, J.J., Gerstein, H., Nga, B.L., Puoliväli, J., Lesné, S., Ashe, K.H., Muchowski, P.J., and Mucke, L., “Enhancing the fibrillization and deposition of the amyloid-b peptide reduces its negative impact on behavior and synaptic activity-dependent proteins”, J. Biol. Chem., 282:23818-23828 (2007). (Full Text)

Rosser, M.F.N., Muchowski, P.J., Patterson, C. and Cyr, D.M., “Chaperone Functions of the E3 Ubiquitin Ligase CHIP”, J. Biol. Chem., 282:22267-22277 (2007). (Full Text)
 

2006

Giorgini, F. and Muchowski, P.J., “Screening for genetic modifiers of amyloid toxicity in yeast”, Methods Enzymol., 412:201-22 (2006). (Full Text)

Finkbeiner, S., Cuervo, A.M., Morimoto, R.I. and Muchowski, P.J., “Disease-modifying pathways in neurodegeneration”, J. Neurosci., 26:10349-57 (2006).(Full Text)

Ehrnhoefer, D.E., Duennwald, M., Markovic, P., Wacker, J.L., Engemann, S., Roark, M., Legleiter, J.L., Marsh, J.L., Thompson, L.M., Lindquist, S., Muchowski, P.J. and Wanker, E.E., “Green tea (-)-epigallocatechin-gallate modulates huntingtin misfolding and reduces toxicity in Huntington’s disease models”, Hum. Mol. Genet., 15: 2743-2751 (2006). Full Text)

Duennwald, M., Jagadish, S., Muchowski, P.J. and Lindquist, S., “Flanking sequences profoundly alter polyglutamine toxicity in yeast”, Proc. Natl. Acad. Sci. U.S.A., 103:11,045-11,050, 2006. Full Text

Duennwald, M., Jagadish, S., Giorgini, F., Muchowski, P.J. and Lindquist, S., “A network of protein interactions determines polyglutamine toxicity”, Proc. Natl. Acad. Sci. U.S.A., 103:11,051-11,056, 2006. Full Text

2005

Giorgini, F., Guidetti, P., Nguyen, Q.V., Bennett, S.C. and Muchowski, P.J., “A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington’s disease”, Nature Genetics, 37:526-531, 2005. (Full Text)

Giorgini, F. and Muchowski, P.J., “Connecting the dots in Huntington’s disease: exploiting protein interaction networks”, Genome Biology, 6:210, 2005. (Full Text) 

Muchowski, P.J. and Wacker, J.L., “Modulation of neurodegeneration by molecular chaperones” Nat. Rev. Neurosci., 6:11-22, 2005. (Full Text)

2004

Wacker, J.L., Zareie, M.H., Fong, H., Sarikaya, M. and Muchowski, P.J., “Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer”, Nat. Struct. and Mol. Biol., 11:1101-1106, 2004. (Full Text)

Outeiro, T.F. and Muchowski, P.J., “Molecular genetics approaches in yeast to study amyloid diseases”, J. Mol. Neurosci., 23:49-60, 2004. (Full Text)

2003

Willingham, S., Outeiro, T.F., DeVit, M.J., Lindquist, S.L. and Muchowski, P.J., “Yeast genes that enhance the toxicity of a mutant huntingtin fragment or a-synuclein”, Science, 302:1769-1772, 2003. (Abstract) (Full Text)

2002

Muchowski, P.J., “Protein misfolding, amyloid formation and neurodegeneration: A critical role for molecular chaperones?”, Neuron, 35:9-12, 2002. (Abstract) (Full Text)