Gladstone's tradition of innovation will continue in multiple areas. First, its cutting-edge scientific research programs have been greatly enhanced by the recent move to a new 200,000 square-foot, six-story research facility on the Mission Bay campus of UCSF. Examples include research to resolve basic questions about Alzheimer's disease and other neurological disorders (Are plaques the whole story in Alzheimer's?), the problems of HIV viral latency (Why can't we cure AIDS?), the repair of damaged heart muscle (What are we learning from stem cell biology that will teach us how to replace or repair dying heart muscle?), and bioinformatics (How do we make sense of the tremendous amounts of data generated from the Human Genome Project?). The state-of-the-art laboratories will allow Gladstone to increase its critical mass of scientists to 30 investigators and a total staff of more than 500. As our basic research matures, potential therapeutic strategies are illuminated. To accelerate the translation of the benefits of our discoveries into patient care, Gladstone has created the Center for Translational Research. Within the Center, Gladstone scientists will collaborate with commercial partners to develop promising therapeutic candidates identified from our basic research efforts. Initial programs will focus on apoE and Alzheimer's disease. In addition, Gladstone will continue to seek collaborations around the world. The Turkish Heart Study identified key risk factors for heart disease and led to new guidelines for treating high cholesterol. New initiatives have begun concerning HIV/AIDS in Africa and Peru and neurodegenerative disease in China. Gladstone is also committed to training the next generation of biomedical scientists. Its innovative training program provides postdoctoral fellows with rigorous instruction in the conduct of science, complemented with formal practical courses on scientific presentations and writing, laboratory management, and mentoring skills. Gladstone was recognized in 2006 as the best place in the United States for postdoctoral training and was ranked second among academic institutions. Through its aggressive diversity programs, Gladstone encourages women and minority scientists to advance their careers in science. Physicians, UCSF medical students, and other health care providers receive advanced training through grand rounds at Gladstone and courses in the management of patients with lipid disorders. Finally, through numerous outreach programs, Gladstone disseminates its research findings to the larger community and from this generation to the next. For example, Gladstone has joined with the National Student Leadership Conference in its program to encourage students to seek careers in science. Gladstone scientists also interact with school children in San Francisco schools to encourage their interest in science. These interactions have included visits to schools, trips to museums, and summer intern programs for students and teachers. In the Science for Life lecture series, Gladstone scientists describe the current state of research in major disease areas for the community. Looking to the Future While our lifestyle and aging population leave us vulnerable to debilitating and deadly diseases, there has never been a more promising convergence of medicine and basic science. The tools to truly conquer disease are now within our grasp. Gladstone's approach to science—entrepreneurial, risk taking, innovative—has proven successful in the past and will ensure that Gladstone scientists will continue to contribute to the health and well-being of people throughout the world.