Gladstone Home GICD Home Blank GIVI Home GIND Home Blank
 
 
Supporting Gladstone
Articles to which the behavioral laboratory contributed
Behavioral Laboratory

Meilandt W, Cisse M, Ho K, Wu T, Esposito L, Scearce-Levie K, Cheng I, Yu G.-Q, Mucke L. (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic AΒ oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J. Neurosci 29:1977-1986.

Sanchez-Mejia RO, Newman JW, Toh S, Yu G.-Q, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L. (2008) Phospholipase A2 reduction ameliorates cognitve deficits in mouse model of Alzheimer's disease. Nat. Neurosci. 11:1311-1318

Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60:247–257.

Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH. (2008) Apolipoprotein E4 domain interation: Synaptic and cognitive deficits in mice. Alzheimer's Dementia 4:179–192.

Meilandt WJ, Yu GQ, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L (2008) Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 28:5007-5017.

Scearce-Levie K, Roberson ED, Gerstein H, Cholfin JA, Mandiyan VS, Shah NM, Rubenstein JL, Mucke L (2008) Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 7:344-354.

Deipolyi AR, Fang S, Palop JJ, Yu GQ, Wang X, Mucke L (2008) Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol. Aging . 29:253-266.

Cheng IH, Scearce-Levie K, Legleiter J, Palop JJ, Gerstein H, Bien-Ly N, Puoliväli J, Lesné S, Ashe KH, Muchowski PJ, Mucke L (2007) Accelerating amyloid-β fibrillization reduces oligomer levels and functional deficits in Alzheimer disease mouse models. J. Biol. Chem. 282:23818-23828.

Roberson ED, Scearce-Levie K, Palop JJ, Yan F, Cheng IH, Wu T, Gerstein H, Yu GQ, Mucke L (2007) Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model. Science 316:750-754.

Esposito L, Raber J, Kekonius L, Yan F, Yu GQ, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L (2006) Reduction in mitochondrial superoxide dismutase modulates Alzheimer's disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 26:5167-5179.

Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer's disease. J. Neurosci. 25:9694–9703.

Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu G-Q, Mucke L (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. I25:9686–9693.

Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc. Natl. Acad. Sci. USA 100:10966-10971.

Palop J, Jones B, Kekonius L, Chin J, Yu G-Q, Raber J, Masliah E, Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer’s disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA 100:9572–9577.

Raber J, Bongers G, LeFevour A, Buttini M, Mucke L (2002) Androgens protect against apoE4-induced cognitive deficits. J. Neurosci. 22:5204–5209.

Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, and Mucke L (2001) β-amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease. Proc. Natl. Acad. Sci. USA 98:12245–12250.

Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L (2000) Hypothalamic-pituitary-adrenal dysfunction in Apoe-/- mice: Possible role in behavioral and metabolic alterations. J. Neurosci. 20:2064–2071.

Raber J, Wong D, Yu G-Q, Buttini M, Mahley RW, Pitas RE, Mucke L (2000) Alzheimer’s disease: Apolipoprotein E and cognitive performance. Nature 404:352–354.

Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in Apoe knockout mice–Increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95:10914–10919.


Gladstone Home | Cardiovascular Disease | Virology and Immunology | Neurological Disease | Administration | UCSF