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2000

Accad M, Smith SJ, Newland DL, Sanan DA, King LE Jr, Linton MF, Fazio S, Farese RV Jr (2000) Massive xanthomatosis and altered composition of atherosclerotic lesions in hyperlipidemic mice lacking acyl CoA:cholesterol acyltransferase 1. J. Clin. Invest. 105:711–719.

Agah R, Prasad KSS, Linnemann R, Firpo MT, Quertermous T, Dichek DA (2000) Cardiovascular overexpression of transforming growth factor-b1 causes abnormal yolk sac vasculogenesis and early embryonic death. Circ. Res. 86:1024–1030.

Antes TJ, Goodart SA, Huynh C, Sullivan M, Young SG, Levy-Wilson B (2000) Identification and characterization of a 315-base pair enhancer, located more than 55 kilobases 5′ of the apolipoprotein B gene, that confers expression in the intestine. J. Biol. Chem. 275:26637–26648.

Bergo MO, Leung GK, Ambroziak P, Otto JC, Casey PJ, Young SG (2000) Targeted inactivation of the isoprenylcysteine carboxyl methyltransferase gene causes mislocalization of K-Ras in mammalian cells. J. Biol. Chem. 275:17605–17610.

Blease K, Mehrad B, Standiford TJ, Lukacs NW, Gosling J, Boring L, Charo IF, Kunkel SL, Hogaboam CM (2000) Enhanced pulmonary allergic responses to Aspergillus in CCR2–/– mice. J. Immunol. 165:2603–2611.

Borén J, Gustafsson M, Skålén K, Flood C, Innerarity TL (2000) Role of extracellular retention of low density lipoproteins in atherosclerosis. Curr. Opin. Lipidol. 11:451–456.

Buhman KF, Accad M, Farese RV Jr (2000) Mammalian acyl-CoA:cholesterol acyltransferases. Biochim. Biophys. Acta 1529:142–154.

Buhman KK, Accad M, Novak S, Choi RS, Wong JS, Hamilton RL, Turley S, Farese RV Jr (2000) Resistance to diet-induced hypercholesterolemia and gallstone formation in ACAT2-deficient mice. Nat. Med. 6:1341–1347.

Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97:207–210.

Camargo FD, Huey-Louie DA, Finn AV, Sassani AB, Cozen AE, Moriwaki H, Schneider DB, Agah R, Dichek DA (2000) Germline incorporation of a replication-defective adenoviral vector in mice does not alter immune responses to adenoviral vectors. Mol. Ther. 2:496–504.

Chang CCY, Sakashita N, Ornvold K, Lee O, Chang ET, Dong R, Lin S, Lee C-YG, Strom SC, Kashyap R, Fung JJ, Farese RV Jr, Patoiseau J-F, Delhon A, Chang TY (2000) Immunological quantitation and localization of ACAT-1 and ACAT-2 in human liver and small intestine. J. Biol. Chem. 275:28083–28092.

Chang MA, Horner JW, Conklin BR, DePinho RA, Bok D, Zack DJ (2000) Tetracycline-inducible system for photoreceptor-specific gene expression. Invest. Ophthalmol. Vis. Sci. 41:4281–4287.

Cheesman EJ, Sharp RJ, Zlot CH, Liu CY-Y, Taylor S, Marcovina SM, Young SG, McCormick SPA (2000) An analysis of the interaction between mouse apolipoprotein B100 and apolipoprotein(a). J. Biol. Chem. 275:28195–28200.

Chen HC, Farese RV Jr (2000) DGAT and triglyceride synthesis: A new target for obesity treatment? Trends Cardiovasc. Med. 10:188–192.

Chen Z, Otto JC, Bergo MO, Young SG, Casey PJ (2000) The C-terminal polylysine region and methylation of K-Ras are critical for the interaction between K-Ras and microtubules. J. Biol. Chem. 275:41251–41257.

Dong J, Balestra ME, Newhouse YM, Weisgraber KH (2000) Human apolipoprotein E7: Lysine mutations in the carboxyl-terminal domain are directly responsible for preferential binding to very low density lipoproteins. J. Lipid Res. 41:1783–1789.

Farese RV Jr, Cases S, Smith SJ (2000) Triglyceride synthesis: Insights from the cloning of diacylglycerol acyltransferase. Curr. Opin. Lipidol. 11:229–234.

Haskell CA, Cleary MD, Charo IF (2000) Unique role of the chemokine domain of fractalkine in cell capture. Kinetics of receptor dissociation correlate with cell adhesion. J. Biol. Chem. 275:34183–34189.

Hogaboam CM, Bone-Larson CL, Steinhauser ML, Matsukawa A, Gosling J, Boring L, Charo IF, Simpson KJ, Lukacs NW, Kunkel SL (2000) Exaggerated hepatic injury due to acetaminophen challenge in mice lacking C–C chemokine receptor 2. Am. J. Pathol. 156:1245–1252.

Hopkins PCR, Pike RN, Stone SR (2000) Evolution of serpin specificity: Cooperative interactions in the reactive-site loop sequence of antithrombin specifically restrict the inhibition of activated protein C. J. Mol. Evol. 51:507–515.

Huang X, Griffiths M, Wu J, Farese RV Jr, Sheppard D (2000) Normal development, wound healing, and adenovirus susceptibility in b5-deficient mice. Mol. Cell. Biol. 20:755–759.

Huang XZ, Wu JF, Ferrando R, Lee JH, Wang YL, Farese RV Jr, Sheppard D (2000) Fatal bilateral chylothorax in mice lacking the integrin a9b1. Mol. Cell. Biol. 20:5208–5215.

Izikson L, Klein RS, Charo IF, Weiner HL, Luster AD (2000) Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2. J. Exp. Med. 192:1075–1080.

Kang S-M, Braat D, Schneider DB, O’Rourke RW, Lin Z, Ascher NL, Dichek DA, Baekkeskov S, Stock PG (2000) A non-cleavable mutant of Fas ligand does not prevent neutrophilic destruction of islet transplants. Transplantation 69:1813–1817.

Klezovitch O, Formato M, Cherchi GM, Weisgraber KH, Scanu AM (2000) Structural determinants in the C-terminal domain of apolipoprotein E mediating binding to the protein core of human aortic biglycan. J. Biol. Chem. 275:18913–18918.

Langer C, Huang Y, Cullen P, Wiesenhütter B, Mahley RW, Assmann G, von Eckardstein A (2000) Endogenous apolipoprotein E modulates cholesterol efflux and cholesteryl ester hydrolysis mediated by high-density lipoprotein-3 and lipid-free apolipoproteins in mouse peritoneal macrophages. J. Mol. Med. 78:217–227.

Leung GK, Véniant MM, Kim SK, Zlot CH, Raabe M, Björkegren J, Neese RA, Hellerstein MK, Young SG (2000) A deficiency of microsomal triglyceride transfer protein reduces apolipoprotein B secretion. J. Biol. Chem. 275:7515–7520.

Lu B, Morrow JA, Weisgraber KH (2000) Conformational reorganization of the four-helix bundle of human apolipoprotein E in binding to phospholipid. J. Biol. Chem. 275:20775–20781.

Lund-Katz S, Zaiou M, Wehrli S, Dhanasekaran P, Baldwin F, Weisgraber KH, Phillips MC (2000) Effects of lipid interaction on the lysine microenvironments in apolipoprotein E. J. Biol. Chem. 275:34459–34464.

MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FHY, Charo IF, Luster AD (2000) CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J. Immunol. 165:6568–6575.

Mahley RW, Pépin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP (2000) Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase: High density lipoprotein characterization and gender-specific effects of apolipoprotein E genotype. J. Lipid Res. 41:1290–1301.

Mahley RW, Rall SC Jr (2000) Apolipoprotein E: Far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1:507–537.

Mietus-Snyder M, Gowri MS, Pitas RE (2000) Class A scavenger receptor up-regulation in smooth muscle cells by oxidized low density lipoprotein. Enhancement by calcium flux and concurrent cyclooxygenase-2 up-regulation. J. Biol. Chem. 275:17661–17670.

Morrow JA, Arnold KS, Dong J, Balestra ME, Innerarity TL, Weisgraber KH (2000) Effect of arginine 172 on the binding of apolipoprotein E to the low density lipoprotein receptor. J. Biol. Chem. 275:2576–2580.

Morrow JA, Segall ML, Lund-Katz S, Phillips MC, Knapp M, Rupp B, Weisgraber KH (2000) Differences in stability among the human apolipoprotein E isoforms determined by the amino-terminal domain. Biochemistry 39:11657–11666.

Mucke L, Buttini M, Mahley RW, Pitas RE, Raber J, Wyss-Coray T (2000) Contributions of the glial injury response to the multifactorial pathogenesis of Alzheimer’s disease. In: Neuro-immune Interactions in Neurologic and Psychiatric Disorders (Patterson P, Kordon C, Christen Y, eds) Springer-Verlag, Berlin, pp 19–33.

Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA (2000) International Union of Pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol. Rev. 52:145–176.

Nguyen TT, Kruckeberg KE, O’Brien JF, Ji Z-S, Karnes PS, Crotty TB, Hay ID, Mahley RW, O’Brien T (2000) Familial splenomegaly: Macrophage hypercatabolism of lipoproteins associated with apolipoprotein E mutation [apolipoprotein E (D149 Leu)]. J. Clin. Endocrinol. Metab. 85:4354–4358.

Peters W, Dupuis M, Charo IF (2000) A mechanism for the impaired IFN-g production in C-C chemokine receptor 2 (CCR2) knockout mice: Role of CCR2 in linking the innate and adaptive immune responses. J. Immunol. 165:7072–7077.

Raber J, Wong D, Yu G-Q, Buttini M, Mahley RW, Pitas RE, Mucke L (2000) Apolipoprotein E and cognitive performance. Nature 404:352–354.

Raffaï R, Weisgraber KH, MacKenzie R, Rupp B, Rassart E, Hirama T, Innerarity TL, Milne R (2000) Binding of an antibody mimetic of the human low density lipoprotein receptor to apolipoprotein E is governed through electrostatic forces. Studies using site-directed mutagenesis and molecular modeling. J. Biol. Chem. 275:7109–7116.

Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR (2000) Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA 97:4826–4831.

Sanan DA, Ladha Z, Newland DL (2000) High throughput quantitative analysis of atherosclerosis in mice. Microsc. Microanal. 6 (Suppl 2):554–555.

Schneider DB, Vassalli G, Wen S, Driscoll RM, Sassani AB, DeYoung MB, Linnemann R, Virmani R, Dichek DA (2000) Expression of Fas ligand in arteries of hypercholesterolemic rabbits accelerates atherosclerotic lesion formation. Arterioscler. Thromb. Vasc. Biol. 20:298–308.

Segelke BW, Forstner M, Knapp M, Trakhanov SD, Parkin S, Newhouse YM, Bellamy HD, Weisgraber KH, Rupp B (2000) Conformational flexibility in the apolipoprotein E amino-terminal domain structure determined from three new crystal forms: Implications for lipid binding. Protein Sci. 9:886–897.

Shih S-J, Allan C, Grehan S, Tse E, Moran C, Taylor JM (2000) Duplicated downstream enhancers control expression of the human apolipoprotein E gene in macrophages and adipose tissue. J. Biol. Chem. 275:31567–31572.

Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr (2000) Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25:87–90.

Terasawa Y, Ladha Z, Leonard SW, Morrow JD, Newland D, Sanan D, Packer L, Traber MG, Farese RV Jr (2000) Increased atherosclerosis in hyperlipidemic mice deficient in a-tocopherol transfer protein and vitamin E. Proc. Natl. Acad. Sci. USA 97:13830–13834.

Véniant MM, Sullivan MA, Kim SK, Ambroziak P, Chu A, Wilson MD, Hellerstein MK, Rudel LL, Walzem RL, Young SG (2000) Defining the atherogenicity of large and small lipoproteins containing apolipoprotein B100. J. Clin. Invest. 106:1501–1510.

Vines DJ, Lee SW, Dichek DA, Ellis V (2000) Receptor-mediated regulation of plasminogen activator function: Plasminogen activation by two directly membrane-anchored forms of urokinase. J. Pept. Sci. 6:432–439.

Wen S, Schneider DB, Driscoll RM, Vassalli G, Sassani AB, Dichek DA (2000) Second-generation adenoviral vectors do not prevent rapid loss of transgene expression and vector DNA from the arterial wall. Arterioscler. Thromb. Vasc. Biol. 20:1452–1458.

Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E (2000) Chronic overproduction of transforming growth factor-b1 by astrocytes promotes Alzheimer’s disease-like microvascular degeneration in transgenic mice. Am. J. Pathol. 156:139–150.

Xu Q, Li Y, Cyras C, Sanan DA, Cordell B (2000) Isolation and characterization of apolipoproteins from murine microglia. Identification of a low density lipoprotein-like apolipoprotein J-rich but E-poor spherical particle. J. Biol. Chem. 275:31770–31777.

Yamanaka S, Zhang X-Y, Maeda M, Miura K, Wang S, Farese RV Jr, Iwao H, Innerarity TL (2000) Essential role of NAT1/p97/DAP5 in embryonic differentiation and the retinoic acid pathway. EMBO J. 19:5533–5541.

Young SG, Ambroziak P, Kim E, Clarke S (2000) Postisoprenylation protein processing: CXXX (CaaX) endoproteases and isoprenylcysteine carboxyl methyltransferase. In: The Enzymes (Tamanoi F, Sigman DS, eds) Academic Press, San Diego, pp 155–213.

Zaiou M, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH, Segall ML, Phillips MC, Lund-Katz S (2000) Apolipoprotein E–low density lipoprotein receptor interaction: Influences of basic residue and amphipathic a-helix organization in the ligand. J. Lipid Res. 41:1087–1095.

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