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2002

Acharya P, Segall ML, Zaiou M, Morrow J, Weisgraber KH, Phillips MC, Lund-Katz S, Snow J (2002) Comparison of the stabilities and unfolding pathways of human apolipoprotein E isoforms by differential scanning calorimetry and circular dichroism. Biochim. Biophys. Acta 1584:9–19.

Beigneux A, Hofmann AF, Young SG (2002) Human CYP7A1 deficiency: Progress and enigmas. J. Clin. Invest. 110:29–31.

Beigneux A, Withycombe SK, Digits JA, Tschantz WR, Weinbaum CA, Griffey SM, Bergo M, Casey PJ, Young SG (2002) Prenylcysteine lyase deficiency in mice results in the accumulation of farnesylcysteine and geranylgeranylcysteine in brain and liver. J. Biol. Chem. 277:38358–38363.

Bergo MO, Ambroziak P, Gregory C, George A, Otto JC, Kim E, Nagase H, Casey PJ, Balmain A, Young SG (2002) Absence of the CAAX endoprotease Rce1: Effects on cell growth and transformation. Mol. Cell. Biol. 22:171–181.

Bergo MO, Gavino B, Ross J, Schmidt WK, Hong C, Kendall LV, Mohr A, Meta M, Genant H, Jiang Y, Wisner ER, van Bruggen N, Carano RAD, Michaelis S, Griffey SM, Young SG (2002) Zmpste24 deficiency in mice causes spontaneous bone fractures, muscle weakness, and a prelamin A processing defect. Proc. Natl. Acad. Sci. USA 99:13049–13054.

Bergo MO, Gavino BJ, Steenbergen R, Sturbois B, Parlow AF, Sanan DA, Skarnes WC, Vance JE, Young SG (2002) Defining the importance of phosphatidylserine synthase 2 in mice. J. Biol. Chem. 277:47701–47708.

Bergo MO, Young SG (2002) Extra Rabs unsnarl a lipid traffic jam. Nat. Med. 8:662–664.

Bersot TP, Palaoglu KE, Mahley RW (2002) Managing dyslipidemia in Turkey: Suggested guidelines for a population characterized by low levels of high density lipoprotein cholesterol. Anadolu Kardiyol. Derg. 4:315–322.

Björkegren J, Beigneux A, Bergo MO, Maher JJ, Young SG (2002) Blocking the secretion of hepatic very low density lipoproteins renders the liver more susceptible to toxin-induced injury. J. Biol. Chem. 277:5476–5483.

Buhman KK, Smith SJ, Stone SJ, Repa JJ, Wong JS, Knapp FF Jr, Burri BJ, Hamilton RL, Abumrad NA, Farese RV Jr (2002) DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis. J. Biol. Chem. 277:25474–25479.

Chen HC, Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert M, Farese RV Jr, Farese RV (2002) Activation of the ERK pathway and atypical protein kinase C isoforms in exercise- and aminoimidazole-4-carboxamide-1-b-D-riboside (AICAR)-stimulated glucose transport. J. Biol. Chem. 277:23554–23562.

Chen HC, Farese RV Jr (2002) Determination of adipocyte size by computer image analysis. J. Lipid Res. 43:986–989.

Chen HC, Farese RV Jr (2002) Fatty acids, triglycerides, and glucose metabolism: Recent insights from knockout mice. Curr. Opin. Clin. Nutr. Metab. Care 5:359–363.

Chen HC, Ladha Z, Farese RV Jr (2002) Deficiency of acyl coenzyme CoA:diacylglycerol acyltransferase 1 increases leptin sensitivity in murine obesity models. Endocrinology 143:2893–2898.

Chen HC, Smith SJ, Ladha Z, Jensen DR, Ferreira LD, Pulawa LK, McGuire JG, Pitas RE, Eckel RH, Farese RV Jr (2002) Increased insulin and leptin sensitivity in mice lacking acyl coenzyme A:diacylglycerol acyltransferase 1. J. Clin. Invest. 109:1049–1055.

Chen HC, Smith SJ, Tow B, Elias PM, Farese RV Jr (2002) Leptin modulates the effects of acyl CoA:diacylglycerol acyltransferase deficiency on murine fur and sebaceous glands. J. Clin. Invest. 109:175–181.

Chen HC, Stone SJ, Zhou P, Buhman KK, Farese RV Jr (2002) Dissociation of obesity and impaired glucose disposal in mice overexpressing acyl coenzyme A:diacylglycerol acyltransferase 1 in white adipose tissue. Diabetes 51:3189–3195.

Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR (2002) GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat. Genet. 31:19–20.

Egashira K, Zhao Q, Kataoka C, Ohtani K, Usui M, Charo IF, Nishida K-I, Inoue S, Katoh M, Ichiki T, Takeshita A (2002) Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys. Circ. Res. 90:1167–1172.

Falkenberg M, Tom C, DeYoung MB, Wen S, Linnemann R, Dichek DA (2002) Increased expression of urokinase during atherosclerotic lesion development causes arterial constriction and lumen loss, and accelerates lesion growth. Proc. Natl. Acad. Sci. USA 99:10665–10670.

Hopkins PCR, Huang Y, McGuire JG, Pitas RE (2002) Evidence for differential effects of apoE3 and apoE4 on HDL metabolism. J. Lipid Res.43:1881–1889.

Huang D, Tani M, Wang J, Han Y, He TT, Weaver J, Charo IF, Tuohy VK, Rollins BJ, Ransohoff RM (2002) Pertussis toxin-induced reversible encephalopathy dependent on monocyte chemoattractant protein-1 overexpression in mice. J. Neurosci. 22:10633–10642.

Innerarity TL (2002) LDL receptor’s b-propeller displaces LDL. Science 298:2337–2338.

Jaworska-Wilczynska M, Wilczynski GM, Engel WK, Strickland DK, Weisgraber KH, Askanas V (2002) Three lipoprotein receptors and cholesterol in inclusion-body myositis muscle. Neurology 58:438–445.

Ji Z-S, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277:21821–21828.

Keppler OT, Welte FJ, Ngo TA, Chin PS, Patton KS, Tsou C-L, Abbey NW, Sharkey ME, Grant RM, You Y, Scarborough JD, Ellmeier W, Littman DR, Stevenson M, Charo IF, Herndier BG, Speck RF, Goldsmith MA (2002) Progress toward a human CD4/CCR5 transgenic rat model for de novo infection by human immunodeficiency virus type 1. J. Exp. Med. 195:719–736.

Leonard SW, Terasawa Y, Farese RV Jr, Traber MG (2002) Incorporation of deuterated RRR- or all-rac-a-tocopherol in plasma and tissues of a-tocopherol transfer protein–null mice. Am. J. Clin. Nutr. 75:555–560.

Ludwig EH, Mahley RW, Palaoglu E, Özbayrakçi S, Balestra ME, Borecki IB, Innerarity TL, Farese RV Jr (2002) DGAT1 promoter polymorphism associated with alterations in body mass index, high density lipoprotein levels and blood pressure in Turkish women. Clin. Genet. 62:68–73.

Ma M, Wei T, Boring L, Charo IF, Ransohoff RM, Jakeman LB (2002) Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion. J. Neurosci. Res. 68:691–702.

Mahley RW, Mahley LL, Bersot TP, Pépin GM, Palaoglu KE (2002) The Turkish lipid problem: Low levels of high density lipoproteins. Turk. J. Endocrinol. Metab. 6:1–12.

Mahley RW, Pépin GM, Bersot TP, Palaoglu KE, Özer K (2002) Turkish Heart Study update: Plasma lipids and treatment guidelines for patients with low levels of high density lipoproteins (in Turkish). Arch. Turk. Soc. Cardiol. 30:93–103.

Mahley RW, Rall SC Jr (2002) Type III hyperlipoproteinaemia (familial dysbetalipoproteinaemia). In: Oxford Textbook of Endocrinology and Diabetes (Wass JAH, Shalet SM, Gale E, Amiel SA, eds) Oxford University Press, Oxford, pp 1554–1561.

Miyake JH, Duong-Polk XT, Taylor JM, Du EZ, Castellani LW, Lusis AJ, Davis RA (2002) Transgenic expression of cholesterol-7-a-hydroxylase prevents atherosclerosis in C57BL/6J mice. Arterioscler. Thromb. Vasc. Biol. 22:121–126.

Morrow JA, Hatters DM, Lu B, Höchtl P, Oberg KA, Rupp B, Weisgraber KH (2002) Apolipoprotein E4 forms a molten globule. A potential basis for its association with disease. J. Biol. Chem. 277:50380–50385.

Raffaï RL (2002) Periplasmic expression and purification of recombinant Fabs. Methods Mol. Biol. 178:343–348.

Raffaï RL, Weisgraber KH (2002) Hypomorphic apolipoprotein E mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J. Biol. Chem. 277:11064–11068.

Roque M, Kim WJH, Gazdoin M, Malik A, Reis ED, Fallon JT, Badimon JJ, Charo IF, Taubman MB (2002) CCR2 deficiency decreases intimal hyperplasia after arterial injury. Arterioscler. Thromb. Vasc. Biol. 22:554–559.

Scearce-Levie K, Coward P, Redfern CH, Conklin BR (2002) Tools for dissecting signaling pathways in vivo: Receptors activated solely by synthetic ligands. Methods Enzymol. 343:232–248.

Segall ML, Dhanasekaran P, Baldwin F, Anantharamaiah GM, Weisgraber KH, Phillips MC, Lund-Katz S (2002) Influence of apoE domain structure and polymorphism on the kinetics of phospholipid vesicle solubilization. J. Lipid Res. 43:1688–1700.

Shohet RV, Vega GL, Bersot TP, Mahley RW, Grundy SM, Guerra R, Cohen JC (2002) Sources of variability in genetic association studies: Insights from the analysis of hepatic lipase (LIPC). Hum. Mutat. 19:536–542.

Skålén K, Gustafsson M, Rydberg EK, Hultén LM, Wiklund O, Innerarity TL, Borén J (2002) Subendothelial retention of atherogenic lipoproteins in early atherosclerosis. Nature 417:750–754.

Tylaska LA, Boring L, Weng W, Aiello R, Charo IF, Rollins BJ, Gladue RP (2002) CCR2 regulates the level of MCP-1/CCL2 in vitro and at inflammatory sites and controls T cell activation in response to alloantigen. Cytokine 18:184–190.

Yen C-LE, Stone SJ, Cases S, Zhou P, Farese RV Jr (2002) Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase. Proc. Natl. Acad. Sci. USA 99:8512–8517.

Zeleny M, Swertfeger DK, Weisgraber KH, Hui DY (2002) Distinct apolipoprotein E isoform preference for inhibition of smooth muscle cell migration and proliferation. Biochemistry 41:11820–11823.

Zhu Z, Ma B, Zheng T, Homer RJ, Lee CG, Charo IF, Noble P, Elias JA (2002) IL-13-induced chemokine responses in the lung: Role of CCR2 in the pathogenesis of IL-13-induced inflammation and remodeling. J. Immunol. 168:2953–2962.

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