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Publications 2005
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Arrasate M and Finkbeiner S (2005) Automated microscope system for determining factors that predict neuronal fate. Proc. Natl. Acad. Sci. USA 102:3840–3845.
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Chang S, Ma TR, Miranda RD, Balestra ME, Mahley RW, Huang Y (2005) Lipid -and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc. Natl. Acad. Sci. USA 102:18694–18699.
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Chen J, Zhou Y, Mueller-Steiner S, Chen L-F, Kwon H, Yi S, Mucke L, Gan L (2005) SIRT1 protects against microglia-dependent amyloid β toxicity through inhibiting NF-κB signaling. J. Biol Chem. 280:40364-40374.
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Chin J, Palop JJ, Puoliväli J, Massaro C, Bien-Ly N, Gerstein H, Scearce-Levie K, Masliah E, Mucke L (2005) Fyn kinase induces synaptic and cognitive impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 25:9694–9703.
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Hatters DM, Budamagunta MS, Voss JC, Weisgraber KH (2005) Modulation of apolipoprotein E structure by domain interaction: Differences in lipid-bound and lipid-free forms. J. Biol. Chem. 280:34288–34295.
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Hatters DM, Peters-Libeu CA, Weisgraber KH (2005) Engineering conformational destabilization into mouse apolipoprotein E: A model for a unique property of human apolipoprotein E4. J. Biol. Chem. 280:26477–26482.
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Johnson JK, Diehl J, Mendez MF, Neuhaus J, Shapira JS, Forman M, Chute DJ, Roberson ED, Pace-Savitsky C, Neumann M, Chow TW, Rosen HJ, Forstl H, Kurz A, Miller BL (2005) Frontotemporal lobar degeneration. Arch. Neurol. 62:925–930.
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Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, Christian AA, von Hehn, Whim MD, Yang B (2005) Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Res. 206:133-145.
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Li W, Li Y, Gao F-B (2005) Abelson, enabled, and p120 catenin exert distinct effects on dendritic morphogenesis in Drosophila. Dev. Dyn. 234:512–522.
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Palop JJ, Chin J, Bien-Ly N, Massaro C, Yeung BZ, Yu G-Q, Mucke L (2005) Vulnerability of dentate granule cells to disruption of Arc expression in human amyloid precursor protein transgenic mice. J. Neurosci. 25:9686–9693.
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Peters-Libeu CA, Newhouse Y, Krishnan P, Cheung K, Brooks E, Weisgraber KH, Finkbeiner S (2005) Crystallization and diffraction properties of the Fab fragment of 3B5H10, an antibody specific for disease-causing polyglutamine stretches. Acta. Cryst. 61:1065–1068.
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Raffai RL, Loeb SM, Weisgraber KH (2005) Apolipoprotein E promotes the regression of atherosclerosis independently of lowering plasma cholesterol levels. Arterioscler. Thromb. Vasc. Biol. 25:436–441.
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Ramaswamy G, Xu G, Huang Y, Weisgraber KH (2005) Effect of domain interaction on apolipoprotein E levels in mouse brain. J. Neurosci 25:10658–10663.
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Roberson ED, Hesse JH, Rose KD, Slama H, Johnson JK, Yaffe K, Forman MS, Miller CA, Trojanowski JQ, Kramer JH, Miller BL (2005) Frontotemporal dementia progresses to death faster than Alzheimer Disease. Neurology 65:719–725.
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Rockenstein E, Mante M, Alford M, Adame A, Crews L, Hashimoto M, Esposito L, Mucke L, Masliah E (2005) High β-secretase activity elicits neurodegeneration in transgenic mice despite reductions in amyloid-β levels: Implications for the treatment of Alzheimer’s disease. J. Biol. Chem. 280:32957–32967.
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Ruiz J, Kouiavskaia D, Migliorini M, Robinson S, Saenko EL, Gorlatova N, Li D, Lawrence D, Hyman BT, Weisgraber KH, Strickland DK (2005) The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor. J. Lipid Res. 46:1721–1731.
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Sauer I, Dunay IR, Weisgraber K, Bienert M, Dathe M (2005) An apolipoprotein E-derived peptide mediates uptake of sterically stabilized liposomes into brain capillary endothelial cells. Biochemistry 44:2021–2029.
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Schneider M, Witztum JL, Young SG, Ludwig EH, Miller ER, Tsimikas S, Curtiss LK, Marcovina SM, Taylor JM, Lawn RM, Innerarity TL, Pitas RE. (2005) High-level lipoprotein [a] expression in transgenic mice: evidence for oxidized phospholipids in lipoprotein [a] but not in low density lipoproteins. J. Lipid. Res. 46:769–778.
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Ye S, Huang Y, Mullendorff K, Dong L, Giedt G, Meng EC, Cohen FE, Kuntz ID, Weisgraber KH, Mahley RW (2005) Apolipoprotein (apo) E4 enhances amyloid β peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target. Proc. Natl. Acad. Sci. USA 102:18700–18705.
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Zhang S, Picard MH, Vasile E, Zhu Y, Raffai RL, Weisgraber KH, Krieger M (2005) Diet-induced occlusive coronary atherosclerosis, myocardial infarction, cardiac dysfunction, and premature death in scavenger receptor classs B type I-deficient, hypomorphic apolipoprotein ER61 mice. Circulation 111:3457–3464.
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