Gladstone spacer GICD
 
 
Supporting Gladstone
Publications 2006
  1. Bradley J, Rao VR, Wang J, Carter S, Finkbeiner S (2006) Splice variants of the NR1 subunit differentially induce NMDA receptor-dependent gene expression. J. Neurosci. 26:1065–1076.

  2. Braun NA, Mohler PJ, Weisgraber KH, Hasty AH, Linton MF, Yancey PG, Su YR, Fazio S, Swift LL (2006) Intracellular trafficking of recycling apolipoprotein E in Chinese hamster ovary cells. J. Lipid Res. 47:1176-1186.

  3. Choi D.-S, Wang D, Yu G.-Q, Zhu G, Kharazia VN, Paredes JP, Chang WS, Deitchman JK Mucke L, Messing RO (2006) PKC epsilon increases endothelin converting enzyme activity and reduces amyloid plaque pathology in transgenic mice. Proc. Natl. Acad Sci. USA 103:8215–8220.

  4. Ehrnhoefer DE, Duennwald M, Markovic P, Wacker JL, Engemann S, Roark M, Legleiter JL, Marsh JL, Thompson LM, Lindquist S, Muchowski PJ, Wanker EE (2006) Green tea (-) epigailocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models. Hum. Mol. Genet.15:2743–2751.

  5. Esposito L, Raber J, Kekonius L, Fan Y, Yu G.-Q, Bien-Ly N, Puoliväli J, Scearce-Levie K, Masliah E, Mucke L (2006) Reduction in mitochondrial superoxide dismutase modulates Alzheimer’s disease-like pathology and accelerates the onset of behavioral changes in human amyloid precursor protein transgenic mice. J. Neurosci. 26:5167–5179.

  6. Finkbeiner S, Cuervo AM, Morimoto RI, Muchowski PJ (2006) Disease-modifying pathways in neurodegeneration. J. Neurosci. 26:10349–10357.

  7. Giorgini F and Muchowski PJ (2006) Screening for genetic modifiers of amyloid toxicity in yeast. Methods Enzymol 412:201–222.

  8. Hatters DM, Peters-Libeu CA, Weisgraber KH (2006) Apolipoprotein E structure: Insights into function. Trends Biochem. Sci. 31:445-454.

  9. Hatters DM, Zhong N, Rutenber E, Weisgraber KH (2006) Amino-terminal domain stability mediates apolipoprotein E aggregation into neurotoxic fibrils. J. Mol. Biol. 361:932–944.

  10. Huang Y (2006) Apolipoprotein E and Alzheimer's disease. Neurology 66:579–585.

  11. Huang Y (2006) Molecular and cellular mechanisms of apolipoprotein E4 neurotoxicity and potential therapeutic strategies. Curr. Opin. Drug Discov. Develop. 9:627–641.

  12. Huang Y and Mahley RW (2006) Commentary: "Perspective on a pathogenesis and treatment of Alzheimer's disease." Apolipoprotein E and the mitochondrial metabolic hypothesis. Alzheimer's Dementia 2:71–73.

  13. Ji Z-S, Mullendorff K, Cheng IH, Miranda D, Huang Y, Mahley RW (2006) Reactivity of apolipoprotein E4 and amyloid β peptide: Lysomal stability and neurodegeneration. J. Biol. Chem. 281:2683–2692.

  14. Li Y, Wang F, Lee J.-A, Gao F.-B (2006) MicroRNA-9a ensures the precise specification of sensory organ precursors in Drosophila. Genes Dev. 20:2793–2805.

  15. Mahley RW and Huang Y (2006) Apolipoprotein (apo) E4 and Alzheimer's disease: Unique conformational and biophysical properties of apoE4 can modulate neuropathology. Acta Neurol Scand Suppl. 185:8-14.

  16. Mahley RW, Huang Y, Weisgraber KH (2006) Putting cholesterol in its place: ApoE and reverse cholesterol transport. J. Clin. Invest. 116: 1226-1229.

  17. Mahley RW, Weisgraber KH, Huang Y (2006) Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease. Proc. Natl. Acad. Sci. U S A 103:5644–5651.

  18. Morris R and Mucke L (2006) Alzheimer's disease: A needle from the haystack. Nature 440:284–285.

  19. Mueller-Steiner S, Zhou Y, Arai H, Sun B, Roberson ED, Chen J, Wang X, Yu G.-Q, Esposito L, Mucke L, Gan L (2006) Anti-amyloidogenic and neuroprotective functions of cathepsin B: Implications for Alzheimer’s disease. Neuron 51:703–714.

  20. Palop JJ, Chin J, Mucke L (2006) A network dysfunction perspective on neurodegenerative diseases. Nature 443:768–773.

  21. Peters-Libeu CA, Newhouse Y, Hatters DM, Weisgraber KH (2006) Model of biologically active apolipoprotein E bound to dipalmitoylphosphatidylcholine. J. Biol. Chem. 281:1073–1079.

  22. Rao VR, Pintchovski SA, Chin J, Peebles CL, Mitra S, Finkbeiner S (2006) AMPA receptors regulate transcription of the plasticity-related immediate-early gene Arc. Nature Neurosci. 9:887–895.

  23. Roberson ED (2006) Frontotemporal dementia. Curr. Neurol. Neurosci. Rep. 6:481–489.

  24. Roberson ED and Mucke L (2006) 100 years and counting: Prospects for defeating Alzheimer’s disease. Science 314:781–784.

  25. Safar JG, Wille H, Geschwind MD, Deering C, Latawiec D, Serban A, King DJ, Legname G, Weisgraber KH, Mahley RW, Miller BL, DeArmond SJ, Prusiner SB (2006) Human prions and plasma lipoproteins. Proc. Natl. Acad. Sci. USA 103: 11312-11317.

  26. Sweeney NT, Brenman JE, Jan YN, Gao F.-B, (2006) The coiled-coil protein shrub controls neuronal morphogenesis in Drosophila. Curr. Biol. 16:1006–1011.

  27. Tassetto M, Gao F.-B (2006) Transcriptional control of dendritic patterning in Drosophila neurons. Genome Biol. 7:225.

  28. Tesseur I, Zou K, Esposito L, Bard F, Berber E, Van Can J, Lin AH, Crews L, Tremblay P, Matthews P, Mucke L, Masliah E, Wyss-Coray T (2006) Deficiency in neuronal TGF-β signaling promotes neurodegeneration and Alzheimer’s pathology. J. Clin. Invest. 116:3060–3069.

  29. Xu Q, Bernardo A, Walker D, Kanegawa T, Mahley RW, Huang Y (2006) Profile and regulation of apolipoprotein E (ApoE) expression in the CNS in mice with targeting of green fluorescent protein gene to the ApoE locus. J. Neurosci. 26:4985–4994.

  30. Xu Q and Huang Y (2006) Lipid metabolism and neurodegenerative disorders. Future Lipidology 1:441–453.

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