Gladstone spacer GICD
 
 
Supporting Gladstone
Publications 2008
  1. Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y (2008) Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc. Natl. Acad. Sci. USA 105:1343–1346.

  2. Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RW, Dolan MJ, McCune JM, Ahuja SK (2008) Apolipoprotein apoE4 influences HIV-1 cell entry in vitro and the ApoE ε4/ε4 genotype accelerates HIV disease progression. Proc. Natl. Acad. Sci. USA 105:8718–8723.

  3. Chin J, Roberson ED, and Mucke L (2008) Molecular aspects of memory dysfunction in Alzheimer's disease. In Learning and Memory:  A Comprehensive Reference. John Byrne (ed), Elsevier 4:245–293.

  4. deIpolyi AR, Fang S, Palop JJ, Yu G.-Q Wang X, Mucke L (2008) Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol. Aging 29:253–266.

  5. Gao F.-B (2008) Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci. 31:20–26.

  6. Delaloy C, Gao F.-B (2008) MicroRNA-9 multitasking near organizing centers. Nat. Neurosci. 11:625–626.

  7. Finkbeiner S, Mitra S (2008) The ubiquitin-proteasome pathway in Huntington's disease. ScientificWorldJournal 8:421–4233.

  8. Gan L, Mucke L (2008) Paths of convergence: Sirtuins in aging and neurodegeneration. Neuron 58:10–14.

  9. Giorgini F, Moller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai L.-CL, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ (2008) Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment J. BIol. Chem. 283:7390–7400.

  10. Huang Y and Mahley RW (2008) Apolipoprotein E: Structure and function in lipid metabolism and neurobiology. In The Molecular and Genetic Basis of Neurological Disease. 4th Edition (Rosenberg RN, DiMauro S, Paulson HL, Ptácek L, Nestler EJ, eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp590–602.

  11. Klionsky D et al., Gao F-B et al. (232 authors) (2008) Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy 4:151–175.

  12. Lee J-A, Gao F-B (2008) Regulation of Aβ pathology by beclin 1: A protective role for autophagy? J. Clin. Invest. 118:2015–2018.

  13. Lee J-A, Gao F-B (2008) Roles of ESCRT in autophagy-associated neurodegeneration. Autophagy 4:230–232.

  14. Meilandt WJ, Yu G.-Q, Chin J, Roberson ED, Palop JJ, Wu T, Scearce-Levie K, Mucke L (2008) Enkephalin elevations contribute to neuronal and behavioral impairments in a transgenic mouse model of Alzheimer’s disease. J. Neurosci. 28:5007–5017.

  15. Muchowski PJ, Ramsden R, Nguyen QV, Arnett EE, Greilling TM, Anderson SK, Clark JL (2008) Noninvasive measurement of protein aggregation by mutant Huntingtin fragments or α-synuclein in the lens. J. Biol. Chem. 283:6330–6336.

  16. Sanchez-Mejia RO, Newman JW, Toh S, Yu G.-Q, Zhou Y, Halabisky B, Cisse M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV, Mucke L (2008) Phospholipase A2 reduction ameliorates cognitive deficits in mouse model of Alzheimer's disease. Nat. Neurosci. 11:1311–1318.

  17. Sandhu MS, Waterworth DM, Debenham SL, Wheeler E, Papadakis K, Zhao JH, Song K, Yuan X, Johnson T, Ashford S, Inouye M, Luben R, Sims M, Hadley D, McArdle W, Barter P, Kesäniemi YA, Mahley RW, McPherson R, Grundy SM, Wellcome Trust Case Control Consortium, Bingham SA, Khaw K-T, Loos RJF, Waeber G, Barroso I, Strachan DP, Deloukas P, Vollenweider P, Wareham NJ, Mooser V (2008) LDL-cholesterol concentrations: A genome-wide association study. Lancet 371:483–491.

  18. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin J, Mandiyan VS, Shah NM, Rubenstein JLR, Mucke L (2008) Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. 7:344–354.

  19. Sun B, Zhou Y, Halabisky B, Lo I, Cho SH, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L (2008) Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60:247–257.

  20. Tamgüney G, Giles K, Glidden DV, Lessard P, Wille H, Tremblay P, Groth DF, Yehiely F, Korth C, Moore RC, Tatzelt J, Rubenstein E, Boucheix C, Yang X, Stanley P, Lisanti MP, Dwek RA, Rudd PM, Moskovitz J, Epstein CJ, Cruz TD, Kuziel WA, Maeda N, Sap J, Ashe KH, Carlson GA, Tesseur I, Wyss-Coray T, Mucke L, Weisgraber KH, Mahley RW, Cohen FE, Prusiner SB (2008) Genes contributing to prion pathogenesis. J. Gen. Virol. 89:1777–1788.

  21. Trinh K, Moore K, Wes PD, Muchowski PJ, Dey J, Andrews L, Pallanck LJ (2008) Induction of the phase II detoxification pathway suppresses neuron loss in Drosophila models of Parkinson's disease. J. Neurosci. 28:465–472.

  22. Xu Q, Walker D, Bernardo A, Brodbeck J, Malestra ME, Huang Y (2008) Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the central nervous system. J. Neurosci. 28:1452–1459.

  23. Xu XL, Li Y, Wang F, Gao F.-B (2008) The steady-state level of the nervous-system-specific microRNA-124a is regulated by dFMR1 in Drosophila. J. Neurosci. 28:11883–11889. (* Equal contribution)

  24. Zhong N, Scearce-Levie K, Ramaswamy G, Weisgraber KH (2008) Apolipoprotein E4 domain interation: Synaptic and cognitive deficits in mice. Alzheimer's & Dementia 4:179–192.

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