Gladstone spacer GICD
 
 
Supporting Gladstone
Publications 2004 -

2004

  1. Arancio O, Zhang HP, Chen X, Lin C, Trinchese F, Puzzo D, Liu S, Hegde A, Yan SF, Stern A, Luddy JS, Lue L-F, Walker DG, Roher A, Buttini M, Mucke L, Li W, Schmidt AM, Kindy M, Hyslop PA, Stern DM, Yan SSD (2004) RAGE potentiates Aβ-induced perturbation of neuronal function in transgenic mice. EMBO J. 31:4096–4105.

  2. Arrasate M, Mitra S, Schweitzer ES, Segal MR, Finkbeiner S (2004) Inclusion body formation reduces the levels of mutant huntingtin and the risk of neuronal death. Nature 431:805–810.

  3. Bongers G, Leurs R, Robertson J, Raber J (2004) Role of H3-receptor-mediated signaling in anxiety and cognition in wild-type and Apoe-/- mice. Neuropsychopharmacology 29:441–449.

  4. Brecht WJ, Harris FM, Chang S, Tesseur I, Yu G-Q, Xu Q, Fish JD, Wyss-Coray T, Buttini M, Mucke L, Mahley RW, Huang Y (2004) Neuron-specific apolipoprotein E4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J. Neurosci. 24:2527–2534.

  5. Brooks L, Arrasate, M, Cheung K, Finkbeiner S (2004) Using antibodies to analyze polyglutamine stretches. In: Methods in Molecular Biology: Triplet Repeat Protocols. Ed., Kohwi Y. Humana Press. 103–128.

  6. Cheng IH, Palop JJ, Esposito LA, Bien-ly N, Yan F, Mucke L (2004) Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation. Nat. Med. 10:1190–1192.

  7. Chin J, Palop JJ, Yu G-Q, Kojima N, Masliah E, Mucke L (2004) Fyn kinase modulates synaptotoxicity, but not aberrant sprouting, in human amyloid precursor protein transgenic mice. J. Neurosci. 24:4692–4697.

  8. Esposito L, Gan L, Yu G-Q, Essrich C, Mucke L (2004) Intracellularly generated amyloid-β peptides counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J. Neurochem. 91:1260–1274.

  9. Harris FM, Tesseur I, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, Huang Y (2004) Astroglial regulation of apolipoprotein E expression in neuronal cells: Implications for Alzheimer’s disease. J. Biol. Chem. 279:3862–3868.

  10. Harris FM, Brecht WJ, Xu Q, Mahley RW, Huang Y (2004) Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: Modulation by zinc. J. Biol. Chem. 279:44795–44801.

  11. Huang Y (2004) Transgenic and gene-targeted mouse models in hypoxic pulmonary hypertension research. In: Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. Editor: Jason XJ. Yuan. 559–568.

  12. Huang Y, Weisgraber KH, Mucke L, Mahley RW (2004) Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer’s disease. J. Mol. Neurosci. 23:189–204.

  13. Li W, Wang F, Menut L, Gao FB (2004) BTB/POZ-Zinc finger protein abrupt suppresses dendritic branching in a neuronal subtype-specific and dosage-dependent manner. Neuron 43:823–834.

  14. Mucke L and Pitas R (2004) Food for thought: Essential fatty acid protects against neuronal deficits in transgenic mouse model of AD. Neuron 43:596–599.

  15. Raber J, Huang Y, Ashford JW (2004) ApoE genotype accounts for the vast majority of AD risk and AD pathology. Neurobiol. Aging 25:641–650.

  16. Xu Q, Brecht WJ, Weisgraber KH, Mahley RW, Huang Y (2004) Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J. Biol. Chem. 279:25511–25516.

  17. Xu K, Bogert BA, Li W, Su K, Lee A, Gao FB (2004) The fragile X-related gene affects the crawling behavior of Drosophila larvae by regulating the mRNA level of the DEG/ENaC protein pickpocket1. Curr. Biol. 14:1025–1034.

2003

  1. Gao F-B, Bogert BA (2003) Genetic control of dendritic morphogenesis in Drosophila. Trends Neurosci. 26:262–268.

  2. Hanson CL, Ilag LL, Malo J, Hatters DM, Howlett GJ, Robinson CV (2003) Phospholipid complexation and association with apolipoprotein C-II: Insights from mass spectrometry Biophys. J. 85:3802–3812.

  3. Harris FM, Brecht WJ, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, Huang Y (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer’s disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc. Natl. Acad. Sci. USA 100:10966–10971.

  4. Lee A, Li W, Xu K, Bogert BA, Su K, Gao F-B (2003) Control of dendritic development by the Drosophila fragile X-related gene involves the small GTPase Rac1. Development 130:5543–5552.

  5. Li W, Gao F-B (2003) Actin filament-stabilizing protein tropomyosin regulates the size of dendritic fields. J. Neurosci. 23:6171–6175.

  6. Li J, Li W, Calhoun HC, Xia F, Gao F-B, Li WX (2003) Patterns and functions of STAT activation during Drosophila embryogenesis. Mech Dev 120:1455–1468.

  7. Mahley RW and Huang Y (2003) Apolipoprotein E: Structure and function in lipid metabolism and neurobiology. In: The Molecular and Genetic Basis of Neurological Disease. Editors: Rosenberg RN, Prusiner SB, DiMauro S, and Barchi RL, Nestler EJ. Butterworth Heinemann, Newton, MA. 565–573.

  8. Palop J, Jones B, Kekonius L, Chin J, Yu G-Q, Raber J, Masliah E, Mucke L (2003) Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer’s disease-related cognitive deficits. Proc. Natl. Acad. Sci. USA 100:9572–9577.

  9. Raffaï RL, Hasty AH, Wang Y, Mettler SE, Sanan DA, Linton MF, Fazio S, Weisgraber KH (2003) Hepatocyte-derived apoE is more effective than non-hepatocyte-derived apoE in remnant lipoprotein clearance. J. Biol. Chem. 278:11670–11675.

  10. Raffaï RL, Weisgraber KH (2003) Cholesterol: From heart attacks to Alzheimer’s disease. J. Lipid Res. 44:1423–1430.

  11. Rao VR, Finkbeiner S (2003) Secrets of a secretase: N-cadherin proteolysis regulates CBP function. Cell 114:533–535.

  12. Santiago-García J, Kodama T, Pitas RE (2003) The class A scavenger receptor binds to proteoglycans and mediates adhesion of macrophages to the extracellular matrix. J. Biol. Chem. 278:6942–6946.

  13. Wyss-Coray T, Loike JD, Brionne TC, Lu E, Anankov R, Yan F, Silverstein SC, Husemann J (2003) Adult mouse astrocytes degrade amyloid-β in vitro and in situ. Nat. Med. 4:453–457.

  14. Wang J, Tanila H, Puolivali J, Kadish I, van Groen T (2003) Gender differences in the amount and deposition of amyloid β in APPswe and PS1 double transgenic mice. Neurobiol. Dis. 14:318–327.

2002

  1. Bradley J, Finkbeiner S (2002) An evaluation of specificity in activity-dependent gene expression in neurons. Prog. Neurobiol. 67:469–477.

  2. Buckwalter M, Pepper J-P, Gaertner RF, Von Euw D, Lacombe P, Wyss-Coray T (2002) Molecular and functional dissection of TGF-β1-induced cerebrovascular abnormalities in transgenic mice. Ann. N.Y. Acad. Sci. 977:87–95.

  3. Buttini M, Yu G-Q, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo FM, Mucke L (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid β peptides but not on plaque formation. J. Neurosci. 22:10539–10548.

  4. Gao F-B (2002) Understanding fragile X syndrome: Insights from retarded flies. Neuron 34:859–862.

  5. Humbert S, Bryson EA, Cordelières FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F (2002) The IGF-1/Akt pathway is neuroprotective in Huntington’s disease and involves huntingtin phosphorylation by Akt. Dev. Cell 2:831–837.

  6. Ji Z-S, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid β peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277:21821–21828.

  7. Morrow JA, Hatters DM, Lu B, Höchtl P, Oberg KA, Rupp B, Weisgraber KH (2002) Apolipoprotein E4 forms a molten globule: A potential basis for its association with disease. J. Biol. Chem. 277:50380–50385.

  8. Raber J, Bongers G, LeFevour A, Buttini M, Mucke L (2002) Androgens protect against apolipoprotein E4-induced cognitive deficits. J. Neurosci. 22:5204–5209.

  9. Raffaï RL, Weisgraber KH (2002) Hypomorphic apolipoprotein E mice. A new model of conditional gene repair to examine apolipoprotein E-mediated metabolism. J. Biol. Chem. 277:11064–11068.

  10. Scearce-Levie K, Coward P, Redfern CH, Conklin BR (2002) Tools for dissecting signaling pathways in vivo: Receptors activated solely by synthetic ligands. Methods Enzymol. 343:232–248.

  11. Sweeney NT, Li W, Gao F-B (2002) Genetic manipulation of single neurons in vivo reveals specific roles of Flamingo in neuronal morphogenesis. Dev. Biol. 247:76–88.

  12. Wyss-Coray T and Mucke L (2002) Inflammation in neurodegenerative disease—a double-edged sword. Neuron 35:419–432.

  13. Wyss-Coray T, Yan F, Lin AH-T, Lambris JD, Alexander JJ, Quigg RJ, Masliah E (2002) Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer’s mice. Proc. Natl. Acad. Sci. USA 99:10837–10842.

2001

  1. Finkbeiner S (2001) New roles for introns: Sites of combinatorial regulation of Ca2+- and cyclic AMP-dependent gene transcription. Science (STKE) 94:1–4.

  2. Huang Y, Lin XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001) Apolipoprotein E fragments present in Alzheimer’s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA 98:8838–8843.

  3. Masliah E, Ho G, Wyss-Coray T (2001) Functional role of TGFβ in Alzheimer’s disease microvascular injury: Lessons from transgenic mice. Neurochem. Int. 39:393–400.

  4. Masliah E, Rockenstein E, Veinbergs I, Sagara Y, Mallory M, Hashimoto M, Mucke L (2001) β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer’s disease and Parkinson’s disease. Proc. Natl. Acad. Sci. USA 98:12245–12250.

  5. Raber J, LeFevour A, Mucke L (2001) Androgen treatment reduces cognitive deficits in female apoE4 transgenic mice. In: Alzheimer’s Disease: Advances in Etiology, Pathogenesis and Therapeutics (Iqbal K, Sisodia SS, Winblad B, eds) John Wiley & Sons, Chichester, West Sussex, England, pp 747–757.

  6. Raffaï RL, Dong L-M, Farese RV Jr, Weisgraber KH (2001) Introduction of human apolipoprotein E4 “domain interaction” into mouse apolipoprotein E. Proc. Natl. Acad. Sci. USA 98:11587–11591.

  7. Santiago-García J, Mas-Oliva J, Innerarity TL, Pitas RE (2001) Secreted forms of the amyloid-β precursor protein are ligands for the class A scavenger receptor. J. Biol. Chem. 276:30655–30661.

  8. Scearce-Levie K, Coward P, Redfern CH, Conklin BR (2001) Engineering receptors activated solely by synthetic ligands (RASSLs). Trends Pharmacol. Sci. 22:414–420.

  9. Wyss-Coray T, Lin C, Yan F, Yu G-Q, Rohde M, McConlogue L, Masliah E, Mucke L (2001) TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice. Nat. Med. 7:612–618.

  10. Wyss-Coray T, McConlogue L, Kindy M, Schmidt AM, Yan SD, Stern DM (2001) Key signaling pathways regulate the biological activities and accumulation of amyloid-β. Neurobiol. Aging 22:967–973.

2000

  1. Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole GM, Cooper NR, Eikelenboom P, Emmerling M, Fiebich BL, Finch CE, Frautschy S, Griffin WST, Hampel H, Hull M, Landreth G, Lue L-F, Mrak R, Mackenzie IR, McGeer PL, O’Banion MK, Pachter J, Pasinetti G, Plata-Salaman C, Rogers J, Rydel R, Shen Y, Streit W, Strohmeyer R, Tooyoma I, Van Muiswinkel FL, Veerhuis R, Walker D, Webster S, Wegrzyniak B, Wenk G, Wyss-Coray T (2000) Inflammation and Alzheimer’s disease. Neurobiol. Aging 21:383–421.

  2. Buttini M, Akeefe H, Lin C, Mahley RW, Pitas RE, Wyss-Coray T, Mucke L (2000) Dominant negative effects of apolipoprotein E4 revealed in transgenic models of neurodegenerative disease. Neuroscience 97:207–210.

  3. Finkbeiner S (2000) CREB couples neurotrophin signals to survival messages. Neuron 25:11–14.

  4. Finkbeiner S (2000) Calcium regulation of the brain-derived neurotrophic factor gene. Cell. Mol. Life Sci. 57:394–401.

  5. Mahley RW, Rall SC Jr (2000) Apolipoprotein E: Far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1:507–537.

  6. Masliah E, Rockenstein E, Veinbergs I, Mallory M, Hashimoto M, Takeda A, Sagara Y, Sisk A, Mucke L (2000) Dopaminergic loss and inclusion body formation in α-synuclein mice: Implications for neurodegenerative disorders. Science 287:1265–1269.

  7. Mucke L, Buttini M, Mahley RW, Pitas RE, Raber J, Wyss-Coray T (2000) Contributions of the glial injury response to the multifactorial pathogenesis of Alzheimer’s disease. In: Neuro-immune Interactions in Neurologic and Psychiatric Disorders (Patterson P, Kordon C, Christen Y, eds) Springer-Verlag, Berlin, pp 19–33.

  8. Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L (2000) High-level neuronal expression of Aβ1–42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation. J. Neurosci. 20:4050–4058.

  9. Mucke L, Yu G-Q, McConlogue L, Rockenstein EM, Abraham CR, Masliah E (2000) Astroglial expression of human α1-antichymotrypsin enhances Alzheimer-like pathology in amyloid protein precursor transgenic mice. Am. J. Pathol. 157:2003–2010.

  10. Raber J, Akana SF, Bhatnagar S, Dallman MF, Wong D, Mucke L (2000) Hypothalamic–pituitary–adrenal dysfunction in Apoe–/– mice: Possible role in behavioral and metabolic alterations. J. Neurosci. 20:2064–2071.

  11. Raber J, Wong D, Yu G-Q, Buttini M, Mahley RW, Pitas RE, Mucke L (2000) Apolipoprotein E and cognitive performance. Nature 404:352–354.

  12. Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington JA, Fishman GI, Bernstein D, Baker AJ, Conklin BR (2000) Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA 97:4826–4831.

  13. Smith SJ, Cases S, Jensen DR, Chen HC, Sande E, Tow B, Sanan DA, Raber J, Eckel RH, Farese RV Jr (2000) Obesity resistance and multiple mechanisms of triglyceride synthesis in mice lacking Dgat. Nat. Genet. 25:87–90.

  14. Wyss-Coray T, Lin C, Sanan DA, Mucke L, Masliah E (2000) Chronic overproduction of transforming growth factor-β1 by astrocytes promotes Alzheimer’s disease-like microvascular degeneration in transgenic mice. Am. J. Pathol. 156:139–150.

  15. Wyss-Coray T, Lin C, von Euw D, Masliah E, Mucke L, Lacombe P (2000) Alzheimer’s disease–like cerebrovascular pathology in transforming growth factor-β1 transgenic mice and functional metabolic correlates. Ann. N.Y. Acad. Sci. 903:317–323.

  16. Wyss-Coray T, Mucke L (2000) Ibuprofen, inflammation and Alzheimer disease. Nat. Med. 6:973–974.

1999

  1. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, Svendsen CN, Mucke L, Johnson MH, Sofroniew MV (1999) Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23: 297–308.

  2. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW (1999) Expression of human apolipoprotein E3 or E4 in the brains of Apoe–/–mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19: 4867–4880.

  3. D’Hooge R, Franck F, Mucke L, De Deyn PP (1999) Age-related behavioural deficits in transgenic mice expressing the HIV-1 coat protein gp120. Eur. J. Neurosci. 11: 4398–4402.

  4. Hsia AY, Masliah E, McConlogue L, Yu G-Q, Tatsuno G, Hu K, Kholodenko D, Malenka RC, Nicoll RA, Mucke L (1999) Plaque-independent disruption of neural circuits in Alzheimer’s disease mouse models. Proc. Natl. Acad. Sci. USA 96: 3228–3233.

  5. Huang F, Buttini M, Wyss-Coray T, McConlogue L, Kodama T, Pitas RE, Mucke L (1999) Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am. J. Pathol. 155: 1741–1747.

  6. Huang Y, Mahley RW (1999) Apolipoprotein E and human disease. In Plasma Lipids and Their Role in Disease (Barter PJ, Rye K-A, eds.) pp. 257–284, Harwood Academic Publishers, Amsterdam.

  7. Mahley RW, Huang Y (1999) Apolipoprotein E: From atherosclerosis to Alzheimer’s disease and beyond. Curr. Opin. Lipidol. 10: 207–217.

  8. Mahley RW, Ji Z-S (1999) Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J. Lipid Res. 40: 1–16.

  9. Mahley RW, Rall SC Jr (1999) Is e4 the ancestral human apoE allele? Neurobiol. Aging 20: 429–430.

  10. Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR (1999) Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17: 165–169.

  11. Xu X, Yang D, Wyss-Coray T, Yan J, Gan L, Sun Y, Mucke L (1999) Wild-type but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 96: 7547–7552.

1998

  1. Bush TG, Savidge TC, Freeman TC, Cox HJ, Campbell EA, Mucke L, Johnson MH, Sofroniew MV (1998) Fulminant jejuno-ileitis following ablation of enteric glia in adult transgenic mice. Cell 93:189–201.

  2. Buttini M, Westland CE, Masliah E, Yafeh AM, Wyss-Coray T, Mucke L (1998) Novel role of human CD4 molecule identified in neurodegeneration. Nat. Med. 4:441–446.

  3. Coward P, Wada HG, Falk MS, Chan SDH, Meng F, Akil H, Conklin BR (1998) Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. USA 95:352–357.

  4. Ji Z-S, Pitas RE, Mahley RW (1998) Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4. J. Biol. Chem. 273:13452–13460.

  5. Krucker T, Toggas SM, Mucke L, Siggins GR (1998) Transgenic mice with cerebral expression of human immunodeficiency virus type-1 coat protein gp120 show divergent changes in short- and long-term potentiation in CA1 hippocampus. Neuroscience 83:691–700.

  6. Mahley RW (1998) Expanding roles for apolipoprotein E in health and disease. In: Atherosclerosis XI (Jacotot B, Mathé D, Fruchart J-C, eds) Elsevier, Amsterdam, pp 117–124.

  7. Marshall DCL, Wyss-Coray T, Abraham CR (1998) Induction of matrix metalloproteinase-2 in human immunodeficiency virus-1 glycoprotein 120 transgenic mouse brains. Neurosci. Lett. 254:97–100.

  8. Masliah E, Raber J, Alford M, Mallory M, Mattson MP, Yang D, Wong D, Mucke L (1998) Amyloid protein precursor stimulates excitatory amino acid transport: Implications for roles in neuroprotection and pathogenesis. J. Biol. Chem. 273:12548–12554.

  9. Mucke L, Buttini M (1998) Molecular basis of HIV-associated neurologic disease. In: Scientific American Molecular Neurology (Martin JB, ed) Scientific American, New York, pp 135–154.

  10. Pitas RE, Ji Z-S, Supekova L, Mahley RW (1998) Divergent metabolism of apolipoproteins E3 and E4 by cells. In: Progress in Alzheimer’s and Parkinson’s Diseases (Fisher A, Hanin I, Yoshida M, eds) Plenum, New York, pp 17–23.

  11. Pitas RE, Ji Z-S, Weisgraber KH, Mahley RW (1998) Role of apolipoprotein E in modulating neurite outgrowth: Potential effect of intracellular apolipoprotein E. Biochem. Soc. Trans. 26:257–262.

  12. Raber J (1998) Detrimental effects of chronic hypothalamic–pituitary–adrenal axis activation. From obesity to memory deficits. Mol. Neurobiol. 18:1–22.

  13. Raber J, Sorg O, Horn TFW, Yu N, Koob GF, Campbell IL, Bloom FE (1998) Inflammatory cytokines: Putative regulators of neuronal and neuro-endocrine function. Brain Res. Rev. 26:320–326.

  14. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95:10914–10919.

  15. Toggas SM, Mucke L (1998) Transgenic models to assess the pathogenic potential of viral products in HIV-1-associated CNS disease. In: The Neurology of AIDS (Gendelman HE, Lipton SA, Epstein L, Swindells S, eds) Chapman & Hall, New York, pp 156–167.

1997

  1. Gutman CR, Strittmatter WJ, Weisgraber KH, Matthew WD (1997) Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor. J. Neurosci. 17:6114–6121.

  2. Mahley RW (1997) Apolipoprotein E: Structure and function in lipid metabolism and neurobiology. In: The Molecular and Genetic Basis of Neurological Disease, 2nd edition (Rosenberg RN, Prusiner SB, DiMauro S, Barchi RL, eds) Butterworth–Heinemann, Boston, pp 1037–1049.

  3. Masliah E, Westland CE, Rockenstein EM, Abraham CR, Mallory M, Veinberg I, Sheldon E, Mucke L (1997) Amyloid precursor proteins protect neurons of transgenic mice against acute and chronic excitotoxic injuries in vivo. Neuroscience 78:135–146.

  4. Mattson MP, Barger SW, Furukawa K, Bruce AJ, Wyss-Coray T, Mark RJ, Mucke L (1997) Cellular signaling roles of TGFβ, TNFα and βAPP in brain injury responses and Alzheimer’s disease. Brain Res. Rev. 23:47–61.

  5. McGeer PL, Walker DG, Pitas RE, Mahley RW, McGeer EG (1997) Apolipoprotein E4 (ApoE4) but not ApoE3 or ApoE2 potentiates β-amyloid protein activation of complement in vitro. Brain Res. 749:135–138.

  6. Pitas RE (1997) Cerebrospinal fluid lipoproteins, lipoprotein receptors, and neurite outgrowth. Nutr. Metab. Cardiovasc. Dis. 7:202–209.

  7. Raber J, Chen S, Mucke L, Feng L (1997) Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of OB effects. J. Biol. Chem. 272:15057–15060.

  8. Raber J, Koob GF, Bloom FE (1997) Interferon-α and transforming growth factor-β1 regulate corticotropin-releasing factor release from the amygdala: Comparison with the hypothalamic response. Neurochem. Int. 30:455–463.

  9. Wyss-Coray T, Borrow P, Brooker MJ, Mucke L (1997) Astroglial overproduction of TGF-β1 enhances inflammatory central nervous system disease in transgenic mice. J. Neuroimmunol. 77:45–50.

  10. Wyss-Coray T, Masliah E, Mallory M, McConlogue L, Johnson-Wood K, Lin C, Mucke L (1997) Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer’s disease. Nature 389:603–606.

  11. Xu X, Raber J, Yang D, Su B, Mucke L (1997) Dynamic regulation of c-Jun N-terminal kinase activity in mouse brain by environmental stimuli. Proc. Natl. Acad. Sci. USA 94:12655–12660.

1996-1995

  1. D’Hooge R, Nagels G, Westland CE, Mucke L, De Deyn PP (1996) Spatial learning deficit in mice expressing human 751-amino acid b-amyloid precursor protein. Neuroreport 7:2807–2811.

  2. Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GVW (1996) Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp. Neurol. 138:252–260.

  3. Mahley RW (1996) Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer’s disease. Isr. J. Med. Sci. 32:414–429.

  4. Mahley RW, Nathan BP, Bellosta S, Pitas RE (1996) Apolipoprotein E: Structure, function, and possible roles in modulating neurite extension and cytoskeletal activity. In: Apolipoprotein E and Alzheimer’s Disease (Roses AD, Weisgraber KH, Christen Y, eds) Springer-Verlag, Berlin, pp 49–58.

  5. Mahley RW, Nathan BP, Pitas RE (1996) Apolipoprotein E. Structure, function, and possible roles in Alzheimer’s disease. Ann. N.Y. Acad. Sci. 777:139–145.

  6. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D (1996) Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F b-amyloid precursor protein and Alzheimer’s disease. J. Neurosci. 16:5795–5811.

  7. Mohajeri MH, Bartsch U, van der Putten H, Sansig G, Mucke L, Schachner M (1996) Neurite outgrowth on non-permissive substrates in vitro is enhanced by ectopic expression of the neural adhesion molecule L1 by mouse astrocytes. Eur. J. Neurosci. 8:1085–1097.

  8. Pitas RE (1996) Microtubule formation and neurite extension are blocked by apolipoprotein E4. Semin. Cell Dev. Biol. 7:725–731.

  9. Raber J, Bloom FE (1996) Arginine vasopressin release by acetylcholine or norepinephrine: Region-specific and cytokine-specific regulation. Neuroscience 71:747–759.

  10. Roses AD, Einstein G, Gilbert J, Goedert M, Han S-H, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi P-T (1996) Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Ann. N.Y. Acad. Sci. 777:146–157.

  11. Weisgraber KH, Dong LM (1996) Role of apolipoprotein E in Alzheimer’s disease: Clues from its structure. In: Apolipoprotein E and Alzheimer’s Disease (Roses AD, Weisgraber KH, Christen Y, eds) Springer-Verlag, Berlin, pp 11–19.

  12. Weisgraber KH, Mahley RW (1996) Human apolipoprotein E: The Alzheimer’s disease connection. FASEB J. 10:1485–1494.

  13. Wyss-Coray T, Masliah E, Toggas SM, Rockenstein EM, Brooker MJ, Lee HS, Mucke L (1996) Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J. Clin. Invest. 97:789–798.

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