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Selected References

Huang Y, and Mahley RW. (1999) Apolipoprotein E and human disease. In Plasma Lipids and Their Role in Diseases. Editor, Philip J. Barter. p. 257–284.

Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, and Mahley RW. (2001) Apolipoprotein E fragments present in Alzheimer''s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA. 98:8838–8843.

Buttini M, Yu GQ, Shockley K, Huang Y, Jones B, Masliah E, Mallory M, Yeo T, Longo M, and Mucke L. (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid b peptides but not on plaque formation. J. Neurosci.22:10539–10548.

Harris FM, Walter JB, Xu Q, Tesseur I, Kekonius L, Wyss-Coray T, Fish JD, Masliah E, Hopkins PC, Scearce-Levie K, Weisgraber KH, Mucke L, Mahley RW, and Huang Y. (2003) Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer’s disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc. Natl. Acad. Sci. USA.100:10966–10971.

Mahley RW, and Huang Y. (2003) Apolipoprotein E: structure and function in lipid metabolism and neurobiology. In The Molecular and Genetic Basis of Neurological Disease. Editors: Rosenberg RN, Prusiner SB, DiMauro S, and Barchi RL, Nestler EJ., Butterworth Heinemann, Newton, MA. p. 565–573.

Harris FM, Tesseur T, Brecht WJ, Xu Q, Mullendorff K, Chang S, Wyss-Coray T, Mahley RW, and Huang Y. (2004) Astroglial regulation of apolipoprotein E expression in neuronal cells: Implications for Alzheimer’s disease. J. Biol. Chem. 279:3862–3868.

Huang Y, Weisgraber KH, Mucke L, and Mahley RW. (2004) Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer’s disease. J. Mol. Neurosci. 23:187–202.


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