Mahley RW (1988) Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240:622–630.Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW (1999) Expression of human apolipoprotein E3 or E4 in the brains of Apoe– /– mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19:4867–4880.
Mahley RW, Huang Y (1999) Apolipoprotein E: From atherosclerosis to Alzheimer’s disease and beyond. Curr. Opin. Lipidol. 10:207–217.
Mahley RW, Rall SC, Jr. (2000) Apolipoprotein E: Far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1:507–537.
Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001) Apolipoprotein E fragments present in Alzheimer’s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA 98:8838–8843.
Ji Z-S, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277:21821–21828.
