Duennwald, M.L, Jagadish, S., Giorgini, F., Muchowski, P.J., & Lindquist, S., “A network of protein interactions determines polyglutamine toxicity”, Proc Natl Acad Sci USA., 103(29): 11051-11056, 2006. [Full Text]

Duennwald, M., Jagadish, S., Muchowski, P.J. and Lindquist, S., “Flanking sequences profoundly alter polyglutamine toxicity in yeast”, Proc Natl Acad Sci USA., 103:11,045-11,050, 2006. [Full Text]

2005

Giorgini, F., Guidetti P., Nguyen, Q.V., Bennett, S.C. & Muchowski, P.J., "A genomic screen in yeast implicates kynurenine 3-monooxygenase as a therapeutic target for Huntington disease", Nat Genet., 37(5), 2005. [Full Text]

Giorgini, F. and Muchowski, P.J., "Connecting the dots in Huntington's disease with protein interaction networks", Genome Biol., 6(3):210, 2005. [Full Text]

Muchowski, P.J. and Wacker, J.L., "Modulation of neurodegeneration by molecular chaperones", Nat Rev Neurosci., 6(1):11-22, 2005. [Full Text]

2004

Wacker, J.L., Zareie, M.H., Fong, H., Sarikaya, M. and Muchowski, P.J., "Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer", Nat. Struct. and Mol. Biol., 11(11):1215-1222, 2004. [Full Text]

Fleming, T.O. and Muchowski, P.J., "Molecular genetic approaches in yeast to study amyloid diseases", J. Mol. Neurosci., 23:49-60, 2004.[Full Text]

2003

Willingham, S., Outeiro, T.F., DeVit, M.J., Lindquist, S.L. and Muchowski, P.J., "Yeast Genes that Enhance the Toxicity of a Mutant Huntingtin Fragment or a-synuclein", Science, 302(5651):1769-72, 2003.
[Abstract] [Full Text]

Miller LC, Swayne LA, Chen L, Feng ZP, Wacker JL, Muchowski PJ, Zamponi GW, Braun JE. "Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin", J. Biol. Chem., 278(52):53072-81, 2003.

Sherman, M.Y. and Muchowski, P.J., "Making Yeast Tremble: Yeast Models as Tools to Study Neurodegenerative Disorders", Neuromolecular Medicine, 4:133-146, 2003.[Full Text]

2002

Muchowski, P.J., "Protein misfolding, amyloid formation, and neurodegeneration: a critical role for molecular chaperones?", Neuron, 35:9-12, 2002.
[Abstract] [Full Text]

Valdez, M.M., Clark, J.I., Wu, G.J.S. and Muchowski, P.J., "Functional similarities between the small heat shock proteins Mycobacterium tuberculosis Hsp16.3 and human aB-crystallin", Eur. J. Biochem., 269:1806-1813, 2002.

Muchowski, P.J., Ning, K., D'Souza-Schorey, C. and Fields, S., "Requirement of an intact microtubule cytoskeleton for aggregation and inclusion body formation by a mutant huntingtin fragment", Proc. Natl. Acad. Sci. U.S.A., 99:727-732, 2002.

2000

Muchowski, P.J., Shaffar, G., Sittler, A., Wanker, E.E., Hayer-Hartl, M.K. and Hartl, F.U., "Hsp70 and Hsp40 chaperones can inhibit self-assembly of polyglutamine proteins into amyloid-like fibrils", Proc. Natl. Acad. Sci. U.S.A., 97:7841-7846, 2000.

Clark, J.I. and Muchowski, P.J., "Small heat-shock proteins and their potential role in human disease", Curr. Opin. Struct. Biol., 10:52-59, 2000.

1999

Perng, M.D., Muchowski, P.J., Ijssel, P.V.D., Wu, J.S., Clark, J.I. and Quinlan, R.A., "The cardiomyopathy and lens cataract mutation in aB-crystallin compromises secondary, tertiary and quaternary protein structure and reduces in vitro chaperone activity", J. Biol. Chem., 274:33235-33243, 1999.

Muchowski, P.J., Hayes, L.G., Yates III, J.R. and Clark, J.I., "ATP and the core 'a;-crystallin' domain of the small heat-shock protein aB-crystallin", J. Biol. Chem., 274:30190-10195, 1999.

Muchowski, P.J., Wu, G., Liang, J.J.N., Adman, E.T. and Clark, J.I., "Site-directed mutations within the core 'a-crystallin' domain of the small heat-shock protein, human aB-crystallin, decrease molecular chaperone functions", J. Mol. Biol., 289:397-411, 1999.

Muchowski, P.J., Valdez, M.M. and Clark, J.I., "aB-crystallin selectively targets intermediate filament proteins during thermal stress", Invest. Opthalmol. Vis. Sci., 40:951-958, 1999.

1998

Muchowski, P.J. and Clark, J.I., "ATP enhanced molecular chaperone functions of the small heat-shock protein human aB Crystallin", Proc. Natl. Acad. Sci. U.S.A., 95:1004-1009, 1998.

1997

Muchowski, P.J., Bassuk, J.A., Lubsen, N.H., and Clark, J.I., "Human aB-crystallin: small heat-shock protein and molecular chaperone", J. Biol. Chem., 272:2578-2582, 1997.