Pathways Responsible for Remnant Lipoprotein Metabolism

Several steps are involved in the plasma clearance of atherogenic chylomicron remnants and VLDL remnants by the liver and apoE is the critical ligand that mediates their binding and uptake (7). A key molecule in the initial capture or sequestration of the remnant lipoproteins in the hepatic space of Disse is HSPG (Figure 2). Subsequent uptake of remnants by hepatocytes involves not only LDL receptors but also the HSPG/LDL receptor–related protein (LRP) pathway. The role of the HSPG/LRP pathway in remnant metabolism and its importance in type III HLP has been recently reviewed (4, 7).

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