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Supporting Gladstone
Curriculum Vitae

Robert W. Mahley, M.D., Ph.D.

Personal Information
Work address: The J. David Gladstone Institutes
1650 Owens Street
San Francisco, California 94158
Family: Linda (wife), Stephen (son), Leslyn (daughter)
Birth date: July 23, 1941
Education
B.S., 1963 Maryville College, Maryville, TN
Ph.D., 1968 Vanderbilt University, Nashville, TN
M.D., 1970 Vanderbilt University, Nashville, TN

Employment History
1963–1964 Instructor of Biology, Maryville College, Maryville, TN
1964–1970 Combined M.D.-Ph.D. program at Vanderbilt University
1970–1971 Pathology Internship, Vanderbilt University, Nashville, TN
1971–1975 Staff, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD
1975–1979 Head, Comparative Atherosclerosis and Arterial Metabolism Section, Laboratory of Experimental Atherosclerosis, NHLBI, NIH, Bethesda, MD
1979– Director, Gladstone Institute of Cardiovascular Disease, San Francisco, CA
1979– Professor of Pathology and Medicine, University of California, San Francisco
1992– President, The J. David Gladstone Institutes, San Francisco, CA
1998– Senior Investigator, Gladstone Institute of Neurological Disease, San Francisco, CA

Selected Awards and Honors
Merrill Award in Experimental Pathology (Vanderbilt University); Bordon Award for Basic Medical Research (Vanderbilt); Vivian B. Allen Medical Scholarship (MD-PhD Program, 1964–1970, Vanderbilt); Heinrich Wieland Prize; George Lyman Duff Memorial Lectureship (American Heart Association award); CIBA-GEIGY Award in Biomedical Research; Metropolitan Life Award for Medical Research in Alzheimer’s Disease; Honorary Degree of Doctor of Medicine, University of Gsoteborg, Sweden; National Cholesterol Education Program DeWitt S. Goodman Award for Basic Science Achievement; Distinguished Alumnus Award, Vanderbilt University School of Medicine; Association of American Physicians (member); American Society for Clinical Investigation (member); Institute of Medicine (member); National Academy of Sciences (member)

Selected Publications
  1. Mahley RW (1988) Apolipoprotein E: Cholesterol transport protein with expanding role in cell biology. Science 240:622–630.
  2. Mahley RW, Weisgraber KH, Hussain MM, Greenman B, Fisher M, Vogel T, Gorecki M (1989) Intravenous infusion of apolipoprotein E accelerates clearance of plasma lipoproteins in rabbits. J. Clin. Invest. 83:2125–2130.
  3. Innerarity TL, Mahley RW, Weisgraber KH, Bersot TP, Krauss RM, Vega GL, Grundy SM, Friedl W, Davignon J, McCarthy BJ (1990) Familial defective apolipoprotein B100: A mutation of apolipoprotein B that causes hypercholesterolemia. J. Lipid Res. 31:1337–1349.
  4. Wilson C, Wardell MR, Weisgraber KH, Mahley RW, Agard DA (1991) Three-dimensional structure of the LDL receptor-binding domain of human apolipoprotein E. Science 252:1817–1822.
  5. Ji Z-S, Fazio S, Lee Y-L, Mahley RW (1994) Secretion-capture role for apolipoprotein E in remnant lipoprotein metabolism involving cell surface heparan sulfate proteoglycans. J. Biol. Chem. 269:2764–2772.
  6. Nathan BP, Bellosta S, Sanan DA, Weisgraber KH, Mahley RW, Pitas RE (1994) Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitro. Science 264:850–852.
  7. Dong L-M, Wilson C, Wardell MR, Simmons T, Mahley RW, Weisgraber KH, Agard DA (1994) Human apolipoprotein E. Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms. J. Biol. Chem. 269:22358–22365.
  8. Bellosta S, Mahley RW, Sanan DA, Murata J, Newland DL, Taylor JM, Pitas RE (1995) Macrophage-specific expression of human apolipoprotein E reduces atherosclerosis in hypercholesterolemic apolipoprotein E–null mice. J. Clin. Invest. 96:2170–2179.
  9. Nathan BP, Chang K-C, Bellosta S, Brisch E, Ge N, Mahley RW, Pitas RE (1995) The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. Biol. Chem. 270:19791–19799.
  10. Bellosta S, Nathan BP, Orth M, Dong L-M, Mahley RW, Pitas RE (1995) Stable expression and secretion of apolipoproteins E3 and E4 in mouse neuroblastoma cells produces differential effects on neurite outgrowth. J. Biol. Chem. 270:27063–27071.
  11. Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois A-M, Cheung V, Onat H, Fulks P, Mahley LL, Vakar F, …zbayrak?1 S, Gskdemir O, Winkler W (1995) Turkish Heart Study: Lipids, lipoproteins, and apolipoproteins. J. Lipid Res. 36:839–859.
  12. Weisgraber KH, Mahley RW (1996) Human apolipoprotein E: The Alzheimer’s disease connection. FASEB J. 10:1485–1494.
  13. Ji Z-S, Dichek HL, Miranda RD, Mahley RW (1997) Heparan sulfate proteoglycans participate in hepatic lipase- and apolipoprotein E-mediated binding and uptake of plasma lipoproteins, including high density lipoproteins. J. Biol. Chem. 272:31285–31292.
  14. Raber J, Wong D, Buttini M, Orth M, Bellosta S, Pitas RE, Mahley RW, Mucke L (1998) Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: Increased susceptibility of females. Proc. Natl. Acad. Sci. USA 95:10914–10919.
  15. Huang Y, Schwendner SW, Rall SC Jr, Sanan DA, Mahley RW (1997) Apolipoprotein E2 transgenic rabbits: Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J. Biol. Chem. 272:22685–22694.
  16. Huang Y, Liu XQ, Rall SC Jr, Taylor JM, von Eckardstein A, Assmann G, Mahley RW (1998) Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J. Biol. Chem. 273:26388–26393.
  17. Ji Z-S, Pitas RE, Mahley RW (1998) Differential cellular accumulation/retention of apolipoprotein E mediated by cell surface heparan sulfate proteoglycans. Apolipoproteins E3 and E2 greater than E4. J. Biol. Chem. 273:13452–13460.
  18. Huang Y, Liu XQ, Rall SC Jr, Mahley RW (1998) Apolipoprotein E2 reduces the low density lipoprotein level in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J. Biol. Chem. 273:17483–17490.
  19. Mahley RW, Huang Y, Rall SC Jr (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): Questions, quandaries, and paradoxes. J. Lipid Res. 40:1933–1949.
  20. Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW (1999) Expression of human apolipoprotein E3 or E4 in the brains of Apoe–/– mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19:4867–4880.
  21. Mahley RW, Huang Y (1999) Apolipoprotein E: From atherosclerosis to Alzheimer’s disease and beyond. Curr. Opin. Lipidol. 10:207–217.
  22. Mahley RW, PZ pin J, Palaoglu KE, Malloy MJ, Kane JP, Bersot TP (2000) Low levels of high density lipoproteins in Turks, a population with elevated hepatic lipase: High density lipoprotein characterization and gender-specific effects of apolipoprotein E genotype. J. Lipid Res. 41:1290–1301.
  23. Mahley RW, Rall SC Jr (2000) Apolipoprotein E: Far more than a lipid transport protein. Annu. Rev. Genomics Hum. Genet. 1:507–537.
  24. Huang Y, Liu XQ, Wyss-Coray T, Brecht WJ, Sanan DA, Mahley RW (2001) Apolipoprotein E fragments present in Alzheimer’s disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA 98:8838–8843.
  25. Mahley RW, Arslan P, Pekcan G, PZpin GM, Aga?diken A, Karaagaoglu N, Rak1c1oglu N, Nursal B, Dayan1kl1 P, Palaoglu KE, Bersot TP (2001) Plasma lipids in Turkish children: Impact of puberty, socioeconomic status, and nutrition on plasma cholesterol and HDL. J. Lipid Res. 42:1996–2006.
  26. Ji Z-S, Miranda RD, Newhouse YM, Weisgraber KH, Huang Y, Mahley RW (2002) Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277:21821–21828.

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