The primary mission of The J. David Gladstone Institutes is to conduct basic research on three of the most important medical problems of modern times: cardiovascular disease, AIDS, and neurodegenerative disorders. Realization of their impact gives Gladstone scientists a sense of purpose and urgency. These diseases place astonishing financial and emotional burdens on the victims, their families and communities, and societies worldwide. As our population ages, the incidence of these diseases will rise, and the cost will threaten our entire health care system. Major medical advances are urgently needed to stem the rising tide of obesity and heart disease, to stop AIDS from devastating entire generations in Africa and other developing areas of the world, and to prevent Alzheimer's and other dementias from robbing society of its resources—including the wisdom of our elders. Research is our best hope. The Gladstone Model The era of brilliant scientists working alone to cure disease is long past. Today, research is a team enterprise, requiring a supportive environment that emphasizes collaboration and provides ready access to the expertise of colleagues, sophisticated instrumentation, and a steady source of funding. Gladstone combines scientific excellence with an entrepreneurial spirit and a clear focus on specific disease areas. The success of Gladstone's research enterprise reflects, in large measure, the Gladstone “model,” an entrepreneurial approach to the conduct of scientific research. Minimize bureaucracy to facilitate rapid decision-making, enabling the organization to take quick advantage of new ideas, new technologies, and new approaches. Partner with the University of California, San Francisco (UCSF), a major university medical center, to provide access to students, patient materials and other resources, and opportunities for collaboration. While independent, Gladstone is formally affiliated with UCSF, and Gladstone investigators hold university appointments and participate in many university activities, including the teaching and training of graduate students. Provide “core” facilities for ready access to specialized techniques, sophisticated instruments, and expertise in their use. Foster collaboration among scientists—internally and externally—with various areas of expertise to create a stimulating environment that fortifies the scientific lifeblood of the organization. Live by core values of excellence, integrity, and teamwork. Leadership at The J. David Gladstone Institutes An efficient leadership team facilitates rapid decision-making and allows Gladstone to take quick advantage of new ideas, new technologies, and new approaches.