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Supporting Gladstone
Publications
2009
  • Kita-Matsuo H, Barcova M, Prigozhina N, Salomonis N, Wei K, et al. (2009) Lentiviral Vectors and Protocols for Creation of Stable hESC Lines for Fluorescent Tracking and Drug Resistance Selection of Cardiomyocytes. PLoS ONE 4(4): e5046. PDF-4.8mb
  • Serina A. Neumann, Whittemore G. Tingley, Bruce R. Conklin, Catherine J. Shrader, Eloise Peet, Matthew F. Muldoon, J. Richard Jennings, Robert E. Ferrell and Stephen B. Manuck (2009) AKAP10 (I646V) functional polymorphism predicts heart rate and heart rate variability in apparently healthy, middle-aged European-Americans. Psychophysiology 46(3) 466–472 PDF-228kb
  • Aalto S, Katriina, Conklin B.R., Lo B. (2009). Obtaining Consent for Future Research with Induced Pluripotent Cells: Opportunities and Challenges. PMID: 19243222 PLoS Biology 7:e42. PDF-1.68 MB
  • Pico, A.R., Smirnov, I.V., Chang, J.S., Yeh, R.F., Wiemels, J.L., Wiencke, J.K., Tihan, T., Conklin, B.R. and Wrensch, M. (2008). SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic acids research 2009 37: D803-D809; doi:10.1093/nar/gkn756. PMID: 18651794 PDF-421 KB

2008

  • Pico AR, Smirnov IV, Chang JS, Yeh RF, Wiemels JL, Wiencke JK, Tihan T, Conklin BR, Wrensch M. (2009) SNPLogic: an interactive single nucleotide polymorphism selection, annotation, and prioritization system. Nucleic Acids Res37(Database issue):D803-9. Epub PDF-422kb
  • van Iersel, M.P., Kelder, T., Pico, A.R., Hanspers, K., Coort, S., Conklin, B.R. and Evelo, C. (2008). Presenting and exploring biological pathways with PathVisio. BMC bioinformatics, 9, 399. PDF-1.68 MB
  • Conklin B.R., Hsiao E.C., Claeysen S, Dumuis A, Srinivasan S, Forsayeth J.R., Guettier J.M., Chang W.C., Pei Y, McCarthy K.D., Nissenson R.A., Wess J, Bockaert J, Roth B.L. (2008) Engineering GPCR signaling pathways with RASSLs.
    Nat Methods. Aug;5(8):673-8. PMID: 18668035     PDF-558.21 KB
  • Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin B.R., Evelo C. (2008). Free in PMC WikiPathways: pathway editing for the people. PLoS Biol. Jul 22;6(7):e184. PMID: 18651794 PDF-558.21 KB
  • Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin B.R. (2008) Free in PMC Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.
    PLoS ONE. 2008 Jul 2;3(7):e2532. PDF-558.21 KB
  • Zhang, L., Zambon, A.C., Vranizan, K., Pothula, K., Conklin, B.R., and Insel, P.A. (2008). Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. The Journal of Biological Chemistry 283, 4304. PDF-558.21 KB
  • Peng, J., Bencsik, M., Louie, A., Lu, W., Millard, S., Nguyen, P., Burghardt, A., Majumdar, S., Wronski, T.J., Halloran, B., Conklin, B.R., and Nissenson, R.A. (2008). Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology 149, 1329. PDF-558.21 KB
  • Ivey, K.N., Muth, A., Arnold, J., King, F.W., Yeh, R.F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., and Srivastava, D. (2008). MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2, 219.PDF-1.5M
  • Hsiao, E.C., Boudignon, B.M., Chang, W.C., Bencsik, M., Peng, J., Nguyen, T.D., Manalac, C., Halloran, B.P., Conklin, B.R., and Nissenson, R.A. (2008). Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105:1209-1214.PDF-480.36 KB

2007

  • Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao, E.C., and Conklin, B.R (2007). Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor. PLoS ONE 2(12): e1317 doi:10.1371/journal.pone.0001317 PDF-1.31MB
  • Zhang, L., Zambon, A.C., Vranizan, K., Pothula, K., Conklin, B.R., and Insel, P.A. (2007). Gene expression signatures of cAMP/PKA-promoted, mitochondrial-dependent apoptosis: Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem PDF-1.31MB
  • Tingley, W.G., Pawlikowska, L., Zaroff, J.G., Kim, T., Nguyen, T., Young, S.G., Vranizan, K., Kwok, P.Y., Whooley, M.A., and Conklin, B.R. (2007). Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A 104:8461-8466.
    • PDF-872.06 KB
  • Sweger, E.J., Casper, K.B., Scearce-Levie, K., Conklin, B.R., and McCarthy, K.D. (2007). Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. J Neurosci 27:2309-2317.PDF- 872.21 KB
  • Srinivasan, S., Santiago, P., Lubrano, C., Vaisse, C., and Conklin, B.R. (2007). Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS ONE 2:e668.PDF-1.31MB
  • Salomonis, N., Hanspers, K., Zambon, A.C., Vranizan, K., Lawlor, S.C., Dahlquist, K.D., Doniger, S.W., Stuart, J., Conklin, B.R., and Pico, A.R. (2007). GenMAPP 2: new features and resources for pathway analysis. BMC Bioinformatics 8:217.PDF-294.09 KB
  • Peng, J., Bencsik, M., Louie, A., Lu, W., Millard, S., Nguyen, P., Burghardt, A., Majumdar, S., Wronski, T.J., Halloran, B., Conklin, B.R., and Nissenson, R.A. (2007). Conditional Expression of a Gi-coupled Receptor in Osteoblasts Results in Trabecular Osteopenia. Endocrinology.PDF-806.79 KB
  • Nord A.S., Vranizan K., Tingley W., Zambon A.C., Hanspers K., Fong L.G., Hu Y., Bachetti P., Ferrin T.E., Babbit P.C., Doniger S.W., Skarnes W.C., Young S.G., Conklin B.R. (2007). Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS ONE. Jul 18; e617. PDF-373.09 KB
  • Kwon C., Arnold J., Hsiao E.C., Taketo M.M., Conklin B.R., Srivastava D. (2007). Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc. Natl. Acad. Sci. Jun 26; 104(26): 10894-9. PDF-986.66 KB
  • Salomonis N., Hanspers K., Zambon A.C., Vranizan K., Lawlor S.C., Dahlquist K.D., Doniger S.W., Stuart J., Conklin B.R., Pico A.R. (2007) GenMAPP 2: New features and resources for pathway analysis. BMC Bioinformatics. Jun 2; 8:217. PDF-430.55 KB
  • Kim W., Ng J.K., Kunitake M.E., Conklin B.R., Yang P. (2007). Interfacing silicon nanowires with mammalian cells. J. Am. Chem. Soc. May 22; 129; 7228-7229. PDF-185.83 KB
  • Conklin B.R. New tools to build synthetic hormonal pathways. Proc. Natl. Acad. Sci. (2007) Mar 20; 104 (12): 4777-4778. PDF-294.09 KB

2006

  • Nord A.S., Chang P.J., Conklin B.R., Cox T., Harper C.A., Hicks G.G., Huang C.C., Johns S.J., Kawamoto M., Liu S., Meng E.C., Morris J.H., Rossant J., Ruiz P., Skarnes W.C., Soriano P., Stanford W.L., Stryke D., Melchner H., Wurst W., Yamamura K., Young S.G., Babbitt P.C., Ferrin T.E. (2006) The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. (34) [PDF-1.4MB]
  • Nicholls R.E., Zhang X., Bailey C.P., Conklin B.R., Kandel E.R., Stanton P.K. (2006) mGluR2 acts through inhibitory Gx subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc. Natl. Acad. Sci. April 18; 103 (16):6380-6385. PDF-1.38 MB

2005

  • Turnbull L., Zhou H.Z., Swigart P.M., Turcato S., Karliner J.S., Conklin B.R., Simpson P.C., Baker A.J. (2005). Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am. J. Physiol. [PDF-552K]
  • Zambon A.C., Zhang L., Minovitsky S., Kanter J.R., Prabhakar S., Salomonis N., Vranizan K., Dubchak I., Conklin B.R., Insel P.A. (2005) Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci. Jun 14;102(24):8561-6. [PDF-696K]
  • McCloskey D.T., Turnbull L., Swigart P.M., Zambon A.C., Turcato S., Joho S., Grossman W., Conklin B.R., Simpson P.C., Baker A.J. (2005). Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol. Genomics. Jun 16;22(1):118-26. [PDF-416K]
  • Scearce-Levie K., Lieberman M.D., Elliott H.H., Conklin B.R.. (2005) Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. BMC Biol. 3:3. [PDF-628K]
  • Salomonis N.S., Cotte N., Zambon A.C., Pollard K.S., Vranizan K., Doniger S.W., Dolganov G., Conklin B.R. (2005) Identifying genetic networks underlying myometrial transition to labor. Genome Biol. 6:R12–R12.16. [PDF-1008K] [Supplementary Data].

2004

  • Skarnes W.C., von Melchner H., Wurst W., Hicks G., Nord A.S., Cox T., Young S.G., Ruiz P., Soriano P., Tessier-Lavigne M., Conklin B.R., Stanford W.L., Rossant J. (2004) A public gene trap resource for mouse functional genomics. Nat. Genet. 36:543–544. PDF-120K
  • Srinivasan S., Lubrano-Berthelier C., Govaerts C., Picard F., Santiago P., Conklin B.R., Vaisse C. (2004) Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J. Clin. Invest. 114:1158–1164. PDF-912K

2003

  • Doniger S.W., Salomonis N., Dahlquist K.D., Vranizan K., Lawlor S.C., Conklin B.R. (2003) MAPPFinder: Using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 4:R7–R7.12. [PDF-139K] [Supplementary Data]
  • Srinivasan S., Vaisse .C, Conklin B.R. (2003) Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann. NY Acad. Sci. 994:225–232. PDF-1.1 MB
  • Segal M.R., Dahlquist K.D., Conklin B.R. (2003) Regression approaches for microarray data analysis. J. Comput. Biol. 10:961-980.
  • Zambon A.C., McDearmon E.L., Salomonis N., Vranizan K., Johansen K., Adey D., Takahashi J.S., Schambelan M., Conklin B.R. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 4:R61–R61.12. [PDF-320K] [Supplementary Data]
  • 2003 Conklin Lab Gladstone Annual Report PDF

2002

  • Dahlquist K.D., Salomonis N., Vranizan K., Lawlor S.C., Conklin B.R. (2002) GenMAPP: A new tool for viewing and analyzing microarray data on biological pathways. Nat. Genet. 31:19–20. PDF-59K
  • 2002 Conklin Lab Gladstone Annual Report PDF

2001

  • Baker A.J., Redfern C.H., Harwood M.D., Simpson P.C., Conklin B.R. (2001) Abnormal contraction caused by expression of Gi-coupled receptor in a transgenic model of dilated cardiomyopathy. Am. J. Physiol. 280:H1653–H1659. PDF-155K
  • Scearce-Levie K., Coward P., Redfern C.H., Conklin BR. (2002) Tools for dissecting signaling pathways in vivo: Receptors activated solely by synthetic ligands (RASSLs). Methods Enzymol. 343:232–248. PDF-113K
  • Scearce-Levie K., Coward P., Redfern C.H., Conklin BR. (2001) Engineering Receptors Activated Solely by Synthetic Ligands (RASSLs). Trends Pharmacol. Sci. 22:414–420. PDF-108K

2000

  • Chang M.A., Horner J.W., Conklin B.R., Bok D., Zack D.J. (2000) Tetracycline-inducible system for photoreceptor-specific gene expression. Invest. Ophthalmol. Vis. Sci. 41:4281–4287.
  • Redfern C.H., Degtyarev M.Y., Kwa A.T., Salomonis N., Cotte N., Nanevicz T., Fidelman N., Desai K., Vranizan K., Lee E.K., Coward P., Shah N., Warrington J., Fishman G.I., Bernstein D., Baker A.J., Conklin B.R. (2000) Conditional expression of a Gi-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA. 97:4826–4831. PDF-313K
  • 2001 Conklin Lab Gladstone Annual Report PDF

1999

  • Coward P., Chan S.D.H., Wada H.G., Humphries G.M., Conklin BR. (1999) Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors. Anal. Biochem. 270:242–248. PDF
  • Redfern C.H., Coward P., Degtyarev M.Y., Lee E.K., Kwa A., Hennighausen L., Bujard H., Fishman G.I., Conklin B.R. (1999) Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17:165–169. PDF-243K
  • Nature Biotechnology News & Views accompanying analysis: Clackson T. (1999) RASSLing with receptors. Nat Biotechnol. 17:131 PDF-151K

1998

  • Coward P., Wada H.G., Falk M.S., Chan S.D.H., Meng F., Akil H., Conklin B.R. (1998) Controlling signaling with a specifically designed Gi-coupled receptor. Proc. Natl. Acad. Sci. USA. 95:352–357. PDF-240K

1997

  • Kostenis E., Conklin B.R., Wess J. (1997) Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with Gaq subunits. Biochem. 36:1487–1495.
  • Kostenis E., Degtyarev M.Y., Conklin B.R., Wess J. (1997) The N-terminal extension of Gaq is critical for constraining the selectivity of receptor coupling. J. Biol. Chem. 272:19107–19110. PDF-212K
  • Burstein E.S., Bräuner-Osborne H., Spalding T.A., Conklin B.R., Brann M.R. (1997) Interactions of muscarinic receptors with the heterotrimeric G proteins Gq and G12: Transduction of proliferative signals. J. Neurochem. 68:525–533.

1996

  • Conklin B.R., Herzmark P., Ishida S., Voyno-Yasenetskaya T.A., Sun Y., Farfel Z., Bourne H.R. (1996) C-Terminal mutations of Gqa and Gsa that alter the fidelity of receptor activation. Mol. Pharmacol. 50:885–890. [PDF-1.2MB]
  • Liu J., Blin N., Conklin B.R., Wess J. (1996) Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. J. Biol. Chem. 271:6172–6178. PDF-207K

1995

  • Liu J., Conklin B.R., Blin N., Yun J., Wess J. (1995) Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc. Natl. Acad. Sci., USA. 92:11642–11646.

1994

  • Chabre O., Conklin B.R., Brandon S., Bourne H.R., Limbird L.E. (1994) Coupling of the a2A-adrenergic receptor to multiple G proteins, a simple approach for estimating receptor-G protein coupling efficiency in a transient expression system. J. Biol. Chem. 269:5730–5734. PDF-556K
  • Voyno-Yasenetskaya T., Conklin B.R., Gilbert R.L., Hooley R., Bourne H.R., Barber D.L. (1994) Ga13 stimulates Na-H Exchange. J. Biol. Chem. 269:4721–4724. PDF-454K
  • Conklin B.R., Bourne H.R. (1994) Homeostatic signals: Marriage of the flytrap and the serpent. Nature, News and Views, 367:22.

1993

  • Lustig K.D., Conklin B.R., Herzmark P., Taussig R., Bourne H.R. (1993) Type II adenylylcyclase integrates coincident signals from Gs, Gi, and Gq. J. Biol.Chem. 268:13900–13905. PDF-719K
  • Conklin B.R., Bourne H.R. (1993) Mouse coat colour reconsidered. Nature Scientific Correspondence, 364:110.
  • Conklin B.R., Bourne H.R. (1993) Structural elements of Ga subunits that interact with Gbg, receptors and effectors. Cell. 73:631–641.
  • Conklin B.R., Farfel Z., Lustig K.D, Julius D., Bourne H.R. (1993) Substitution of three amino acids switches receptor specificity of Gqa to that of Gia. Nature 363:274–276. PDF-860K

1992

  • Bourne H.R., Lustig K.O., Wong Y.H., Conklin B.R. (1992) Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harb. Symp. Quant. Biol. LVII:145–148.
  • Chabre O., Conklin B.R., Lin H.Y., Lodish H.F., Wilson E., Ives H.E., Catanzariti L., Hemmings B.A., Bourne H.R. (1992) A recombinant calcitonin receptor independently stimulates 3´,5´-cyclic adenosine monophosphate and Ca2+/inositol phosphate signaling pathways. Mol. Endocrinol. 6:551–556.
  • Federman A.D., Conklin B.R., Schrader K.A., Reed R.R., Bourne H.R. (1992) Hormonal stimulation of adenylyl cyclase via Gi protein bg subunits. Nature 354:159–161.
  • Wong Y.H., Conklin B.R., Bourne H.R. (1992) Gz mediates hormonal inhibition of cyclic AMP accumulation. Science 255:339–342.
  • Conklin B.R., Chabre O., Wong Y.H., Federman A.D., Bourne H.R. (1992) Recombinant Gqa: mutational activation and coupling to receptors and phospholipase C. J. Biol. Chem. 267:31–33. PDF-450K

1989

  • Felder C.C., Ma A.L., Conklin B.R. (1989) Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor. FEBS Lett. 245:75–79.

1988

  • Conklin B.R., Brann M.R., Buckley N.J., Ma A.L., Bonner T.I., Axelrod J. (1988) Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes of muscarinic receptor subtypes stably expressed in A9 L cells. Proc. Natl. Acad. Sci., USA. 85:8698–8702.
  • Conklin B.R,. Burch R.M., Steranka L.R., Axelrod J. (1988) Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts. J. Pharmacol. Exp. Ther. 244(2):646–649.

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