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2008

• Conklin B.R., Hsiao E.C., Claeysen S, Dumuis A, Srinivasan S, Forsayeth J.R., Guettier J.M., Chang W.C., Pei Y, McCarthy K.D., Nissenson R.A., Wess J, Bockaert J, Roth B.L. Engineering GPCR signaling pathways with RASSLs.
  Nat Methods. 2008 Aug;5(8):673-8. PMID: 18668035 [PubMed - in process] PDF-558.21 KB
• Pico AR, Kelder T, van Iersel MP, Hanspers K, Conklin B.R., Evelo C. Free in PMC WikiPathways: pathway editing for the people. PLoS Biol. 2008 Jul 22;6(7):e184. No abstract available. PMID: 18651794 [PubMed - in process] PDF-558.21 KB
• Hsiao EC, Yoshinaga Y, Nguyen TD, Musone SL, Kim JE, Swinton P, Espineda I, Manalac C, deJong PJ, Conklin B.R. Free in PMC Marking embryonic stem cells with a 2A self-cleaving peptide: a NKX2-5 emerald GFP BAC reporter.
  PLoS ONE. 2008 Jul 2;3(7):e2532. PDF-558.21 KB
• Zhang, L., Zambon, A.C., Vranizan, K., Pothula, K., Conklin, B.R., and Insel, P.A.,Gene expression signatures of cAMP/protein kinase A (PKA)-promoted, mitochondrial-dependent apoptosis. Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. The Journal of biological chemistry 283, 4304 (2008). PDF-558.21 KB
• Peng, J., Bencsik, M., Louie, A., Lu, W., Millard, S., Nguyen, P., Burghardt, A., Majumdar, S., Wronski, T.J., Halloran, B., Conklin, B.R., and Nissenson, R.A.,Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology 149, 1329 (2008). PDF-558.21 KB
• Ivey, K.N., Muth, A., Arnold, J., King, F.W., Yeh, R.F., Fish, J.E., Hsiao, E.C., Schwartz, R.J., Conklin, B.R., Bernstein, H.S., and Srivastava, D.,MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell stem cell 2, 219 (2008).PDF-1.5M
• Hsiao, E.C., Boudignon, B.M., Chang, W.C., Bencsik, M., Peng, J., Nguyen, T.D., Manalac, C., Halloran, B.P., Conklin, B.R., and Nissenson, R.A. 2008. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc Natl Acad Sci U S A 105:1209-1214.PDF-480.36 KB

2007

• Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsiao, E.C., and Conklin, B.R (2007). Modifying Ligand-Induced and Constitutive Signaling of the Human 5-HT4 Receptor. PLoS ONE 2(12): e1317 doi:10.1371/journal.pone.0001317 PDF-1.31MB
• Zhang, L., Zambon, A.C., Vranizan, K., Pothula, K., Conklin, B.R., and Insel, P.A. 2007. Gene expression signatures of cAMP/PKA-promoted, mitochondrial-dependent apoptosis: Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J Biol Chem PDF-1.31MB
• Tingley, W.G., Pawlikowska, L., Zaroff, J.G., Kim, T., Nguyen, T., Young, S.G., Vranizan, K., Kwok, P.Y., Whooley, M.A., and Conklin, B.R. 2007. Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation. Proc Natl Acad Sci U S A 104:8461-8466.
PDF-872.06 KB
• Sweger, E.J., Casper, K.B., Scearce-Levie, K., Conklin, B.R., and McCarthy, K.D. 2007. Development of hydrocephalus in mice expressing the G(i)-coupled GPCR Ro1 RASSL receptor in astrocytes. J Neurosci 27:2309-2317.PDF- 872.21 KB
• Srinivasan, S., Santiago, P., Lubrano, C., Vaisse, C., and Conklin, B.R. 2007. Engineering the melanocortin-4 receptor to control constitutive and ligand-mediated G(S) signaling in vivo. PLoS ONE 2:e668.PDF-1.31MB
• Salomonis, N., Hanspers, K., Zambon, A.C., Vranizan, K., Lawlor, S.C., Dahlquist, K.D., Doniger, S.W., Stuart, J., Conklin, B.R., and Pico, A.R. 2007. GenMAPP 2: new features and resources for pathway analysis. BMC Bioinformatics 8:217.PDF-294.09 KB
• Peng, J., Bencsik, M., Louie, A., Lu, W., Millard, S., Nguyen, P., Burghardt, A., Majumdar, S., Wronski, T.J., Halloran, B., Conklin, B.R., and Nissenson, R.A. 2007. Conditional Expression of a Gi-coupled Receptor in Osteoblasts Results in Trabecular Osteopenia. Endocrinology.PDF-806.79 KB
• Nord AS, Vranizan K, Tingley W, Zambon AC, Hanspers K, Fong LG, Hu Y, Bachetti P, Ferrin TE, Babbit PC, Doniger SW, Skarnes WC, Young SG, Conklin BR. Modeling insertional mutagenesis using gene length and expression in murine embryonic stem cells. PLoS ONE. (2007) Jul 18; e617. PDF-373.09 KB
• Kwon C, Arnold J, Hsiao EC, Taketo MM, Conklin BR, Srivastava D. Canonical Wnt signaling is a positive regulator of mammalian cardiac progenitors. Proc. Natl. Acad. Sci. (2007) Jun 26; 104(26): 10894-9. PDF-986.66 KB
• Salomonis N, Hanspers K, Zambon AC, Vranizan K, Lawlor SC, Dahlquist KD, Doniger SW, Stuart J, Conklin BR, Pico AR. GenMAPP 2: New features and resources for pathway analysis. BMC Bioinformatics. (2007) Jun 2; 8:217. PDF-430.55 KB
• Kim W, Ng JK, Kunitake ME, Conklin BR, Yang P. Interfacing silicon nanowires with mammalian cells. J. Am. Chem. Soc. (2007) May 22; 129; 7228-7229. PDF-185.83 KB
• Conklin BR. New tools to build synthetic hormonal pathways. Proc. Natl. Acad. Sci. (2007) Mar 20; 104 (12): 4777-4778. PDF-294.09 KB

2006

• Nord AS, Chang PJ, Conklin BR, Cox T, Harper CA, Hicks GG, Huang CC, Johns SJ, Kawamoto M, Liu S, Meng EC, Morris JH, Rossant J, Ruiz P, Skarnes WC, Soriano P, Stanford WL, Stryke D, Melchner H, Wurst W, Yamamura K, Young SG, Babbitt PC, Ferrin TE. (2006) The International Gene Trap Consortium Website: a portal to all publicly available gene trap cell lines in mouse. Nucleic Acids Res. (34) [PDF-1.4MB]
• Nicholls RE, Zhang X, Bailey CP, Conklin BR, Kandel ER, Stanton PK. (2006) mGluR2 acts through inhibitory Gx subunits to regulate transmission and long-term plasticity at hippocampal mossy fiber-CA3 synapses. Proc. Natl. Acad. Sci. April 18; 103 (16):6380-6385. PDF-1.38 MB

2005

• Turnbull L, Zhou HZ, Swigart PM, Turcato S, Karliner JS, Conklin BR, Simpson PC, Baker AJ.(2005) Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator. Am. J. Physiol. [PDF-552K]
• Zambon AC, Zhang L, Minovitsky S, Kanter JR, Prabhakar S, Salomonis N, Vranizan K, Dubchak I, Conklin BR, Insel PA.(2005) Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A. Proc Natl Acad Sci. Jun 14;102(24):8561-6. [PDF-696K]
• McCloskey DT, Turnbull L, Swigart PM, Zambon AC, Turcato S, Joho S, Grossman W, Conklin BR, Simpson PC, Baker AJ. Cardiac transgenesis with the tetracycline transactivator changes myocardial function and gene expression. Physiol. Genomics. 2005 Jun 16;22(1):118-26. [PDF-416K]
• Scearce-Levie K, Lieberman MD, Elliott HH, Conklin BR. (2005) Engineered G protein coupled receptors reveal independent regulation of internalization, desensitization and acute signaling. BMC Biol. 3:3. [PDF-628K]
• Salomonis NS, Cotte N, Zambon AC, Pollard KS, Vranizan K, Doniger SW, Dolganov G, Conklin BR. (2005) Identifying genetic networks underlying myometrial transition to labor. Genome Biol. 6:R12–R12.16. [PDF-1008K] [Supplementary Data].

2004

• Skarnes WC, von Melchner H, Wurst W, Hicks G, Nord AS, Cox T, Young SG, Ruiz P, Soriano P, Tessier-Lavigne M, Conklin BR, Stanford WL, Rossant J. (2004) A public gene trap resource for mouse functional genomics. Nat. Genet. 36:543–544. PDF-120K
• Srinivasan S, Lubrano-Berthelier C, Govaerts C, Picard F, Santiago P, Conklin BR, Vaisse C. (2004) Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans. J. Clin. Invest. 114:1158–1164. PDF-912K

2003

• Doniger SW, Salomonis N, Dahlquist KD, Vranizan K, Lawlor SC, Conklin BR. (2003) MAPPFinder: Using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol. 4:R7–R7.12. [PDF-139K] [Supplementary Data]
• Srinivasan S, Vaisse C, Conklin BR. (2003) Engineering the melanocortin-4 receptor to control G(s) signaling in vivo. Ann. NY Acad. Sci. 994:225–232. PDF-1.1 MB
• Segal MR, Dahlquist KD, Conklin BR. (2003) Regression approaches for microarray data analysis. J. Comput. Biol. 10:961-980.
• Zambon AC, McDearmon EL, Salomonis N, Vranizan K, Johansen K, Adey D, Takahashi JS, Schambelan M, Conklin BR. Time- and exercise-dependent gene regulation in human skeletal muscle. Genome Biol. 4:R61–R61.12. [PDF-320K] [Supplementary Data]
• 2003 Conklin Lab Gladstone Annual Report PDF

2002

• Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR. (2002) GenMAPP: A new tool for viewing and analyzing microarray data on biological pathways. Nat. Genet. 31:19–20. PDF-59K
• 2002 Conklin Lab Gladstone Annual Report PDF

2001

• Baker AJ, Redfern CH, Harwood MD, Simpson PC, Conklin BR. (2001) Abnormal contraction caused by expression of G_i-coupled receptor in a transgenic model of dilated cardiomyopathy. Am. J. Physiol. 280:H1653–H1659. PDF-155K
• Scearce-Levie K, Coward P, Redfern CH, Conklin BR. (2002) Tools for dissecting signaling pathways in vivo: Receptors activated solely by synthetic ligands (RASSLs). Methods Enzymol. 343:232–248. PDF-113K
• Scearce-Levie K, Coward P, Redfern CH, Conklin BR. (2001) Engineering Receptors Activated Solely by Synthetic Ligands (RASSLs). Trends Pharmacol. Sci. 22:414–420. PDF-108K

2000

• Chang MA, Horner JW, Conklin BR, Bok D, Zack DJ. (2000) Tetracycline-inducible system for photoreceptor-specific gene expression. Invest. Ophthalmol. Vis. Sci. 41:4281–4287.
• Redfern CH, Degtyarev MY, Kwa AT, Salomonis N, Cotte N, Nanevicz T, Fidelman N, Desai K, Vranizan K, Lee EK, Coward P, Shah N, Warrington J, Fishman GI, Bernstein D, Baker AJ, Conklin BR. (2000) Conditional expression of a G_i-coupled receptor causes ventricular conduction delay and a lethal cardiomyopathy. Proc. Natl. Acad. Sci. USA. 97:4826–4831. PDF-313K
• 2001 Conklin Lab Gladstone Annual Report PDF

1999

• Coward P, Chan SDH, Wada HG, Humphries GM, Conklin BR. (1999) Chimeric G proteins allow a high-throughput signaling assay of G_i-coupled receptors. Anal. Biochem. 270:242–248. PDF
• Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa A, Hennighausen L, Bujard H, Fishman GI, Conklin BR. (1999) Conditional expression and signaling of a specifically designed G_i-coupled receptor in transgenic mice. Nat. Biotechnol. 17:165–169. PDF-243K
• Nature Biotechnology News & Views accompanying analysis: Clackson T. (1999) RASSLing with receptors. Nat Biotechnol. 17:131 PDF-151K

1998

• Coward P, Wada HG, Falk MS, Chan SDH, Meng F, Akil H, Conklin BR. (1998) Controlling signaling with a specifically designed G_i-coupled receptor. Proc. Natl. Acad. Sci. USA. 95:352–357. PDF-240K

1997

• Kostenis E, Conklin BR, Wess J. (1997) Molecular basis of receptor/G protein coupling selectivity studied by coexpression of wild type and mutant m2 muscarinic receptors with G_aq subunits. Biochem. 36:1487–1495.
• Kostenis E, Degtyarev MY, Conklin BR, Wess J. (1997) The N-terminal extension of G_aq is critical for constraining the selectivity of receptor coupling. J. Biol. Chem. 272:19107–19110. PDF-212K
• Burstein ES, Bräuner-Osborne H, Spalding TA, Conklin BR, Brann MR. (1997) Interactions of muscarinic receptors with the heterotrimeric G proteins G_q and G₁₂: Transduction of proliferative signals. J. Neurochem. 68:525–533.

1996

• Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR. (1996) C-Terminal mutations of G_qa and G_sa that alter the fidelity of receptor
activation. Mol. Pharmacol. 50:885–890. [PDF-1.2MB]
• Liu J, Blin N, Conklin BR, Wess J. (1996) Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. J. Biol. Chem. 271:6172–6178. PDF-207K

1995

• Liu J, Conklin BR, Blin N, Yun J, Wess J. (1995) Identification of a receptor/G-protein contact site critical for signaling specificity and G-protein activation. Proc. Natl. Acad. Sci., USA. 92:11642–11646.

1994

• Chabre O, Conklin BR, Brandon S, Bourne HR, Limbird LE. (1994) Coupling of the a_2A-adrenergic receptor to multiple G proteins, a simple approach for estimating receptor-G protein coupling efficiency in a transient expression system. J. Biol. Chem. 269:5730–5734. PDF-556K
• Voyno-Yasenetskaya T, Conklin BR, Gilbert RL, Hooley R, Bourne HR, Barber DL. (1994) Ga13 stimulates Na-H Exchange. J. Biol. Chem. 269:4721–4724. PDF-454K
• Conklin BR, Bourne HR. (1994) Homeostatic signals: Marriage of the flytrap and the serpent. Nature, News and Views, 367:22.

1993

• Lustig KD, Conklin BR, Herzmark P, Taussig R, Bourne HR. (1993) Type II adenylylcyclase integrates coincident signals from G_s, G_i, and G_q. J. Biol.Chem. 268:13900–13905. PDF-719K
• Conklin BR, Bourne HR. (1993) Mouse coat colour reconsidered. Nature Scientific Correspondence, 364:110.Conklin BR, Bourne HR. (1993) Structural elements of Ga subunits that interact with Gbg, receptors and effectors. Cell. 73:631–641.
• Conklin BR, Farfel Z, Lustig KD, Julius D, Bourne HR. (1993) Substitution of three amino acids switches receptor specificity of G_qa to that of G_ia. Nature 363:274–276. PDF-860K

1992

• Bourne HR, Lustig KO, Wong YH, Conklin BR. (1992) Detection of coincident signals by G proteins and adenylyl cyclase. Cold Spring Harb. Symp. Quant. Biol. LVII:145–148.
• Chabre O, Conklin BR, Lin HY, Lodish HF, Wilson E, Ives HE, Catanzariti L, Hemmings BA, Bourne HR. (1992) A recombinant calcitonin receptor independently stimulates 3´,5´-cyclic adenosine monophosphate and Ca²⁺/inositol phosphate signaling pathways. Mol. Endocrinol. 6:551–556.
• Federman AD, Conklin BR, Schrader KA, Reed RR, Bourne HR. (1992) Hormonal stimulation of adenylyl cyclase via G_i protein bg subunits. Nature 354:159–161.
• Wong YH, Conklin BR, Bourne HR. (1992) G_z mediates hormonal inhibition of cyclic AMP accumulation. Science 255:339–342.
• Conklin BR, Chabre O, Wong YH, Federman AD, Bourne HR. (1992) Recombinant G_qa: mutational activation and coupling to receptors and phospholipase C. J. Biol. Chem. 267:31–33. PDF-450K

1989

• Felder CC, Ma AL, Conklin BR. (1989) Carbachol-induced reverse transformation of Chinese hamster ovary cells transfected with and expressing the m5 muscarinic acetylcholine receptor. FEBS Lett. 245:75–79.

1988

• Conklin BR, Brann MR, Buckley NJ, Ma AL, Bonner TI, Axelrod J. (1988) Stimulation of arachidonic acid release and inhibition of mitogenesis by cloned genes of muscarinic receptor subtypes stably expressed in A9 L cells. Proc. Natl. Acad. Sci., USA. 85:8698–8702.
• Conklin BR, Burch RM, Steranka LR, Axelrod J. (1988) Distinct bradykinin receptors mediate stimulation of prostaglandin synthesis by endothelial cells and fibroblasts. J. Pharmacol. Exp. Ther. 244(2):646–649.

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