Gladstone Institute of Cardiovascular Disease
Bruce Conklin has been cited by Scientific American for one of the top 50 achievements in business, policy, and research for the year 2007. Dr. Conklin and Peidong Yang, PhD, of UC Berkeley collaborated to demonstrate a new way to show how external signals affect the differentiation of embryonic stem (ES) cells into other types of cells. The scientists used nanoscale silicon wires embedded in mouse ES cells to deliver signals from their surrounding environments. The mouse cells then became heart cells, which survived and proliferated for several days. Drs. Conklin and Yan noted that the technique could be used to guide differentiation of stem cells into specific tissue types through electrical pulses or chemicals transmitted via nanowires.
Sylvaine Cases and Robert Farese, Jr., received patent #7,238,779 for “Acyl CoA:choloesterol acyltransferase (ACAT-2).” The invention consists of the nucleic acid compositions encoding all or part of novel ACAT proteins, including ACAT-2, and methods of producing said nucleic acids and proteins. The patent covers ACAT-2 homologues found in plant and animal species and engineered variants of ACAT-2.
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Gladstone Institute of Virology and Immunology
Ya-Lin Chiu was appointed as an assistant investigator in GIVI.
Warner Greene was appointed president of the Academic Alliance Foundation.
Andrew Hebbeler was chosen as associate editor for the National Postdoctoral Association's quarterly newsletter, The POSTDOCket.
Melanie Ott was appointed as an associate investigator in GIVI.
Eric Verdin, Brian North, and Bjoern Schwer were issued U.S. Patent No. 7,273,713 for “Methods of Modulating Mitochondrial and NAD-Dependent Deacetylase.” Acetylating or deacetylating amino acid residues within a protein is an important mechanism to regulate protein activity and function. The inventors developed an assay method that measures the extent to which test compounds modulate the activity of SIRT3 by measuring the change in level of substrate acetylation in the presence or absence of the test compound.
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Gladstone Institute of Neurological Disease
Sarah Carter completed her PhD thesis requirements in the laboratory of Steven Finkbeiner.
Fen-Biao Gao was selected to serve as a member of the Synapses, Cytoskeleton, and Trafficking Study Section at the National Institutes of Health.
Sean Pintchovski completed his PhD thesis requirements in the laboratory of Steven Finkbeiner.
Gladstone Administration
John LeViathan was re-elected to the Board of the National Postdoctoral Association.
Dan Oshiro served as co-program chair of the annual meeting of the Association of Independent Research Institutes in Washington, DC, in September 2007.
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