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Supporting Gladstone
Recent Publications
Gladstone communicates the findings of its studies to the larger research community by presentations at national and international scientific meetings and by publishing papers in scientific journals. Before a paper can be published, it must be carefully scrutinized by other scientists, a process known as peer review. Since 1979, Gladstone investigators have published over 1775 papers. Listed here are the latest publications.

 

GICD

Chan LC, Peters W, Xu Y, Chun J, Farese RV Jr, Cases S (2007) LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J. Leukoc. Biol. 82:1193–1200.

Chang WC, Ng JK, Nguyen T, Pellissier L, Claeysen S, Hsaio EC, Conklin BR. Modifying ligand-induced and constitutive signaling of the human 5-HT4 receptor. PLoS ONE. In press.

Cline MS, Smoot M, Cerami E, Kuchinsky A, Landys N, Workman C, Christmas R, Avila-Campilo I, Creech M, Gross B, Hanspers K, Isserlin R, Kelley R, Killcoyne S, Lotia S, Maere S, Morris J, Ono K, Pavlovic V, Pico AR, Vailaya A, Wang PL, Adler A, Conklin BR, Hood L, Kuiper M, Sander C, Schmulevich I, Schwikowski B, Warner GJ, Ideker T, Bader GD (2007) Integration of biological networks and gene expression data using Cytoscape. Nat. Protoc. 2:2366–2382.

Hsaio EC, Boudignon BM, Chang WC, Bencsik M, Peng J, Nguyen TD, Manalac C, Halloran BP, Conklin BR, Nissenson RA. Osteoblast expression of an engineered Gs-coupled receptor dramatically increases bone mass. Proc. Natl. Acad. Sci. USA. In press.

Kim W, Ng JK, Kunitake ME, Conklin BR, Yang P (2007) Interfacing silicon nanowires with mammalian cells. J. Am. Chem. Soc. 129:7228–7229.

Levin MC, Monetti M, Watt MJ, Sajan MP, Stevens RD, Bain JR, Newgard CB, Farese RV Sr, Farese RV Jr (2007) Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle. Am. J. Physiol. Endocrinol. Metab. 293:E1772–E1781.

Lewitzky M, Yamanaka S (2007) Reprogramming somatic cells towards pluripotency by defined factors. Curr. Opin. Biotechnol. 18:467–473.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell Biol. 27:8807–8814.

Nakagawa M, Koyanagi M, Tanabe K, Takahashi K, Ichisaka T, Aoi T, Okita K, Mochiduki Y, Takizawa N, Yamanaka S. (2008) Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts. Nat. Biotechnol. 26:101–106.

Nigam V, Srivastava D. (2007) Molecular regulation of cardiogenesis. In Inborn Errors of Development (Epstein CJ, ed) 2nd Ed., Oxford University Press, Oxford, pp 124–129.

Okita K, Ichisaka T, Yamanaka S (2007) Generation of germline-competent induced pluripotent stem cells. Nature 448:313–317.

Peng J, Bencsik M, Louie A, Lu W, Millard S, Nguyen P, Burghardt A, Majumdar S, Wronski TJ, Halloran B, Conklin BR, Nissenson RA. Conditional expression of a Gi-coupled receptor in osteoblasts results in trabecular osteopenia. Endocrinology. In press.

Peters-Libeu CA, Newhouse Y, Hall SC, Witkowska HE, Weisgraber KH (2007) Apolipoprotein E*dipalmitoylphosphatidylcholine particles are ellipsoidal in solution. J. Lipid Res. 48:1035–1044.

Ransom J, Srivastava D (2007) The genetics of cardiac birth defects. Semin. Cell Dev. Biol. 18:132–139.

Saederup N, Chan L, Lira SA, Charo IF. Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2–/– mice. Evidence for independent chemokine functions in atherogenesis. Circulation. In press.

  Saxena A, Fish JE, White MD, Yu S, Smyth JWP, Shaw RM, DiMaio JM, Srivastava D. Stromal cell-derived factor-1α is cardioprotective after myocardial infarction. Circulation. In press.

Srivastava D, Saxena A, Dimaio JM, Bock-Marquette I (2007) Thymosin β4 is cardioprotective after myocardial infarction. Ann. NY Acad. Sci. 1112:161–170.

Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861–872.

Yamanaka S, Li J, Kania G, Elliott S, Wersto RP, Van Eyk J, Wobus AM, Boheler KR. (2008) Pluripotency of embryonic stem cells. Cell Tissue Res. 331:5–22.

Zhang L, Zambon AC, Vranizan K, Pothula K, Conklin BR, Insel PA. Gene expression signatures of cAMP/PKA-promoted, mitochondrial-dependent apoptosis: Comparative analysis of wild-type and cAMP-deathless S49 lymphoma cells. J. Biol. Chem. In press.

 
GIVI

Ahuja N, Schwer B, Carobbio S, Waltregny D, North BJ, Castronovo V, Maechler P, Verdin E (2007) Regulation of insulin secretion by SIRT4, a mitochondrial ADP-ribosyltransferase. J. Biol. Chem. 282:33583–33592.

Bourara K, Liegler TJ, Grant RM (2007) Target cell APOBEC3C can in-duce limited G-to-A mutation in HIV-1. PLoS Pathog. 3:1477–14485.

Chen L-f, Greene WC (2007) Regulation of nuclear NF-B action: A key role for posttranslational modification. In: Handbook of Transcription Factor NF-κB (Ghosh S, ed.), CRC Press, Boca Raton, FL, pp. 87–105.

Chiu Y-L, Greene WC. The APOBEC3 Cytidine Deaminases: An Innate Defensive Network Opposing Exogenous Retroviruses and Endogenous Retroelements. Ann. Rev. Immunol. In press.

Garrison KE, Jones RB, Meiklejohn DA, Anwar N, Ndhlovu LC, Chapman JM, Erickson AL, Agrawal A, Spotts G, Hecht FM, Rakoff-Nahoum S, Lenz J, Ostrowski MA, Nixon DF (2007) T cell responses to human endogenous retroviruses in HIV-1 infection. PLoS Pathog. 3:e165.

Goffinet C, Michel N, Allespach I, Tervo HM, Hermann V, Kraeusslich HG, Greene WC, Keppler OT (2007) Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression. Retrovirology 4:53.

Grant RM (2007) Research in situ. Nat. Methods 4:887–890.

Greene WC. (2007) Molecular biology of HIV: Implications for new therapies. In: Global HIV/AIDS Medicine (Sande M, Lange J, Volberding P, Greene WC, eds.), Elsevier, Philadelphia, pp. 23–38.

Greene WC (2007) A history of AIDS: Looking back to see ahead. Eur. J. Immunol. 37:S94–S102.

Legrand FA, Nixon DF, Loo CP, Ono E, Chapman JM, Miyamoto M, Diaz RS, Santos AMN, Succi RCM, Abadi J, Rosenberg MG, de Moraes-Pinto MI, Kallas EG (2007) Strong HIV-1–specific T cell responses in HIV-1–exposed uninfected infants and neonates revealed after regulatory T cell removal. PLoS One 1:e102.

Lombard DB, Alt FW, Cheng HL, Bunkenborg J, Streeper RS, Mostoslavsky R, Kim J, Yancopoulos G, Valenzuela D, Murphy A, Yang Y, Chen Y, Hirschey MD, Bronson RT, Haigis M, Guarente LP, Farese RV Jr, Weissman S, Verdin E, Schwer B (2007) Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation. Mol. Cell Biol. 27:8807–8814.

  Napolitano, LA, Schmidt, D, Gotway, M., Ameli, N, Filbert, EL, Ng, MN, Clor, JL, Epling, L, Sinclair, E, Li, K, Baum, P, Killian, ML, Bacchetti, P, McCune, JM. Growth Hormone Enhances Thymic Function in HIV-infected Adults. J. Clin. Invest. In press.

North BJ, Verdin E (2007) Interphase nucleo-cytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2:e784.

Roan NR, Greene WC. A seminal finding for understanding HIV transmission. Cell 131:1044–1046.

Schafer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Diskmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M. Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem. In press.

Verdin E (2007) AROuSing SIRT1: identification of a novel endogenous SIRT1 activator. Mol. Cell 28:354–356.

Williams SA, Greene WC (2007) Regulation of HIV-1 latency by T-cell activation. Cytokine 39:63–74.

 
GIND

Brodbeck J, Balestra ME, Saunders AM, Roses AD, Mahley RW, Huang Y. Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons. Proc. Natl. Acad. Sci. USA. In press.

deIpolyi AR, Fang S, Palop JJ, Yu G-Q, Wang X, Mucke L (2008) Altered navigational strategy use and visuospatial deficits in hAPP transgenic mice. Neurobiol. Aging 29:253–266.

deIpolyi AR, Rankin K, Mucke L, Miller B, Gorno-Tempini ML (2007) Spatial cognition and the human navigation network in AD and MCI. Neurology 69:986–997.

Gao F-B (2007) Molecular and cellular mechanisms of dendritic morphogenesis. Curr. Opin. Neurobiol. 17, 525–532.

Gao F-B. Posttranscriptional control of neuronal development by microRNA networks. Trends Neurosci. In press.

Giorgini F, Möller T, Kwan W, Zwilling D, Wacker JL, Hong S, Tsai L-CL, Cheah CS, Schwarcz R, Guidetti P, Muchowski PJ. Histone deacetylase inhibition modulates kynurenine pathway activation in yeast, microglia, and mice expressing a mutant huntingtin fragment. J. Biol. Chem. In press.

Huang Y, Mahley RW. Apolipoprotein E: structure and function in lipid metabolism and neurobiology. In The Molecular and Genetic Basis of Neurological Disease. Editors: Rosenberg RN, DiMauro S, Paulson H, Ptacek L, Nestler EJ. Butterworth Heinemann, Newton, MA. In press.

Mahley RW, Huang Y (2007) Atherogenic remnant lipoproteins: Role for proteoglycans in trapping, transferring, and internalizing. J. Clin. Invest. 117:94–98.

Peebles CL, Finkbeiner S (2007) RNA decay back in play. Nat. Med. 10:1083–1084. Scearce-Levie K, Roberson ED, Gerstein H, Cholfin J, Mandiyan VS, Shah NM, Rubenstein JLR, Mucke L. Abnormal social behaviors in mice lacking Fgf17. Genes Brain Behav. In press.

Xu Q, Walker D, Bernardo A, Brodbeck J, Malestra ME, Huang Y. Intron-3 retention/splicing controls neuronal expression of apolipoprotein E in the central nervous system. J. Neurosci. In press.

Zhang Y, Vasudevan S, Sojitrawala R, Zhao W, Cui C, Xu C, Fan D, Newhouse Y, Balestra R, Jerome WG, Weisgraber K, Li Q, Wang J (2007) A monomeric, biologically active, full-length human apolipoprotein E. Biochemistry 46:10722–10732.

Zhong N, Ramaswamy G, Scearce-Levie K, Weisgraber KH. Apolipoprotein E4 domain interaction results in synaptic deficits and cognitive impairment in mice. Alzheimers Dementia. In press.

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