Research Articles (peer reviewed)

1. Sun B, Halabisky B, Zhou Y, Yu G, Mucke L, Gan L. (2009) Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease. Cell Stem Cell. In press.
   

2. Sanchez-Mejia RO, Newman JW, Toh S, Yu GQ, Zhou Y, Halabisky B, Cissé M, Scearce-Levie K, Cheng IH, Gan L, Palop JJ, Bonventre JV and Mucke L. (2008) Phopholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer’s disease. Nat. Neurosci. 11:1311–1318.
   

3. Sun B, Zhou Y, Halabisky B, Lo I, Cho S, Mueller-Steiner S, Devidze N, Wang X, Grubb A, Gan L. (2008) Cystatin C-cathepsin B axis regulates soluble amyloid beta and associated neuronal deficits in an animal model of Alzheimer's disease. Neuron 60:247–257.
   

4. Mueller-Steiner S, Zhou Y, Arai H, Sun B, Roberson ED, Chen J, Yu G, Wong X, Esposito L, Mucke L, Gan L. (2006) Anti-amyloidogenic and neuroprotective functions of cathepsin B: Implications for Alzheimer’s disease. Neuron. 51:703–714.
   

5. Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, Gan L. (2005) SIRT1 protects against microglia-dependent beta amyloid toxicity through inhibiting NF-κB signaling. J. Biol. Chem. 280:40364–40374.
   

6. Kaczmarek LK, Bhattacharjee A, Desai R, Gan L, Song P, Christian AA, von Hehn, Whim MD, Yang B. (2005) Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels. Hearing Res. 206:133–145.
   

7. Gresch O, Engel FB, Nesic D, Tran TT, England HM, Hickman ES, Korner I, Gan L, Chen S, Hammermann R, Wolf J, Muller-Hartmann H, Nix M, Siebenkotten G, Kraus G, Lun K. (2004) New non-viral method for gene-transfer into primary cells. Methods 33:151–163.
   

8. Esposito L†, Gan L†, Yu G-Q, Essrich C, Mucke L. (2004) Intracellularly generated Aβ counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells. J. Neurochem. 91:1260–1274. (†authors contribute equally)
   

9. Gan L, Ye S, Chu A, Anton KE, Yi S, Vincent VA, Von Schack D, Chin D, Murray J, Lohr S, Patthy L, Gonzalez-Zulueta M, Nikolich K, Urfer R. (2004) Identification of cathepsin B as a mediator of neuronal death induced by Aβ-activated microglial cells using a functional genomics approach. J. Biol. Chem. 279:5565–5572.
   

10. Ford BD, Liu Y, Mann MA, Krauss R, Phillips K, Gan L, Fischbach GD. (2003) Neuregulin-1suppresses muscarinic receptor expression and acetylcholine-activated muscarinic K+ channels in cardiac myocytes. Biochem. Biophys. Res. Commun. 308:23–28.
    

11. Bhattacharjee A, Gan L, Kaczmarek LK. (2002) Localization of the slack potassium channel in the rat central nervous system. J. Comp. Neurol. 454:241–254.
    

12. Gan L, Anton KE, Masterson BA, Vincent V, Ye S, Gonzalez-Zulueta M. (2002) Specific interference with gene expression and gene function mediated by long dsRNA in neuronal cells. J. Neurosci. Methods 121:151–157.
    

13. Gan L, Hahn SJ, Kaczmarek LK. (1999) Cell-type specific expression of the Kv3.1 gene is mediated by negative elements in the 5' UTR in the proximal region of the Kv3.1 promoter. J. Neurochem. 73:1350–1362.
    

14. Xu X, Yang D, Wyss-Coray T, Yan, J, Gan L, Sun Y, Mucke L. (1999) Wildtype but not Alzheimer-mutant amyloid precursor protein confers resistance against p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA 96:7547–7552.
    

15. Joiner WJ, Tang MD, Wang L-Y, Dworezky SI, Boissard CG, Gan L, Gribkoff VK, Kaczmarek LK. (1998) Formation of intermediated-conductance calcium-activated potassium channels by interaction of slack and slo subunits. Nat. Neurosci. 1:462–469.
    

16. Gan L, Kaczmarek LK. (1998) When, where, and how much? Expression of the Kv3.1 potassium channel in high frequency firing neurons. J. Neurobiol. 37:69–79.
    

17. Wang L-Y, Gan L, Perney TM, Shwartz I, Kaczmarek LK. (1998) Activation of Kv3.1 channels in neuronal spine-like structures may induce local potassium depletion. Proc. Natl. Acad. Sci. USA 95:1882–1887.
    

18. Wang L-Y, Gan L, Forsythe ID, Kaczmarek LK. (1998) Contribution of the Kv3.1 potassium channel to high-frequency firing in mouse auditory neurones. J. Physiol. Lond. 509:183–194.
    

19. Gan L, Perney TM, Kaczmarek LK. (1996) Cloning and characterization of the promoter for a potassium channel expressed in high frequency firing neurons. J. Biol. Chem. 271:5859–5865.
    

20. Kanemasa T, Gan L, Perney TM, Wang L-Y, Kaczmarek LK. (1995) The regulation of the Kv3.1 potassium current in NIH3T3 fibroblasts by PKC. J. Neurophysiol. 74:207–217.
    

    
    

Other Publications

1. Sun B, Gan L. (2009) Methods in Alzheimer’s disease and Frontotemporal dementia. In: Manipulation of Gene Expression in the CNS with Viral Vector. Humana Press Inc. In Press.
   

2. Gan L. (2008) Research progress in Alzheimer’s disease and dementia. Nova Science Publisher, Inc., New York. Chapter X, Vol. 3, pp. 275–302.
   

3. Gan L, Mucke L. (2008) Paths of convergence: Sirtuins in aging and neurodegeneration. Neuron 58:10–14.
   

4. Gan L. (2007) Therapeutic potential of sirtuin-activating compounds in Alzheimer’s disease. Drug News Perspect. 20:233–239.
   

5. Gan L. (2007) Therapeutic potential of amyloid-β-degrading enzymes in Alzheimer’s disease. Fut. Neurol. 2:133–137.