The mission of the Gladstone Institute of Cardiovascular Disease is to contribute to the health and welfare of humankind through research into the causes and prevention of cardiovascular disease.
Director: Deepak Srivastava, M.D. ••• 1650 Owens Street, San Francisco, CA 94158
Tel: (415) 734-2716 ••• Fax: (415) 355-0960 |
Gladstone and Stanford In Collaboration to Develop Induced Pluripotent Stem (IPS) Cells for Cardiac Therapies
National Heart Lung and Blood Institute funds multi-year, multimillion dollar project to focus on stem and progenitor cell tools and treatments
SAN FRANCISCO, CA—November 1, 2009—Scientists at the Gladstone Institute of Cardiovascular Disease (GICD) and Stanford University School of Medicine will collaborate in a new consortium funded by the National Heart, Lung and Blood Institute (NHLBI) to develop stem cell and regenerative medicine therapies. GICD investigators, led by GICD Director Deepak Srivastava, MD, will collaborate with a Stanford team led by Robert Robbins, MD, professor and chair of cardiothoracic surgery, to investigate how to use induced pluripotent stem cells, or iPS cells, to repair damaged heart muscle.
See press release.
See article in SF Chronicle.
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GLADSTONE’S SHINYA YAMANAKA WINS LASKER AWARD
Cited for reprogramming discovery that changes adult cells to
embryonic-like stem cells
September 13, 2009 – Shinya Yamanaka, MD, PhD, of the Gladstone Institute of Cardiovascular Disease (GICD) and Kyoto University, has won the 2009 Albert Lasker Basic Medical Research Award for his discovery of a method of reprogramming adult skin cells to become embryonic-like stem cells. Yamanaka, who is the L.K. Whittier Investigator in Stem Cell Biology at Gladstone, is one of the youngest recipients of the award, which is seen as a precursor to the Nobel Prize.
See press release. |
BRUNEAU: Reptilian heart development and the molecular basis of cardiac chamber evolution
SRIVASTAVA: miR-145 and miR-143 regulate smooth muscle cell fate and plasticity
BRUNEAU: Directed transdifferentiation of mouse mesoderm to heart tissue by defined factors
FARESE: Deficiency of the intestinal enzyme MGAT2 protects mice from metabolic disorders induced by high-fat feeding
FARESE: Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin
SRIVASTAVA: Cardiac Fibroblasts Regulate Myocardial Proliferation through beta-1 Integrin Signaling
POLLARD: A Genome-Wide Approach to Identifying Novel-Imprinted Genes
YAMANAKA: Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors
CONKLIN: WikiPathways: Pathway Editing for the People
YAMANAKA: Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells
CHARO: A chemokine receptor essential for mobilization of monocytes from bone marrow during hypercholesterolemia |
Gladstone Scientists Receive $10 Million to Identify Genetic Cause of Congenital Heart Disease
National Heart, Lung, Blood Institute Funds Multi-Year Project
SAN FRANCISCO, CA—October 28, 2009—Scientists at the Gladstone Institute of Cardiovascular Disease (GICD) will receive $10 million over the next 6 years to find the genetic causes of congenital heart disease. Congenital heart disease affects 1 percent of all children and often leads to death or long-term illness. The team of investigators, led by Benoit Bruneau, PhD, will focus on the gene networks that underlie the disease and the regulatory factors that turn on and off genes related to congenital heart defects (CHDs). GICD was one of four national centers awarded this highly competitive grant to address CHD at a genome-wide level.
See press release. |
Gladstone Scientists Find First Genetic Link Between Reptile and Human Heart Evolution
September 2, 2009—Scientists at the Gladstone Institute of Cardiovascular Disease (GICD) have traced the evolution of the four-chambered human heart to a common genetic factor linked to the development of hearts in turtles and other reptiles.
See press release.
See related video coverage from ABC 7 KGO San Francisco. |
