The mission of the Gladstone Institute of Cardiovascular Disease is to contribute to the health and welfare of humankind through research into the causes and prevention of cardiovascular disease. Director: Deepak Srivastava, M.D. ••• 1650 Owens Street, San Francisco, CA 94158 Tel: (415) 734-2716 ••• Fax: (415) 355-0960
In the News		Featured Articles
Gladstone's Shinya Yamanaka Wins “Baby Nobel” April 8, 2009—Shinya Yamanaka, MD, PhD, of the Gladstone Institutes and Kyoto University is one of seven recipients of Canada's prestigious Gairdner Award. The Gairdner is referred to as the “Baby Nobel,” since many winners then go on to win the Nobel Prize. See press release.	Gladstone Scientists Identify Key Factors in Heart Cell Creation April 26, 2009—Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells. See press release.	FARESE: Deficiency of the intestinal enzyme acyl CoA: monoacylglycerol acyltransferase-2 protects mice from metabolic disorders induced by high-fat feeding FARESE: Retinol Esterification by DGAT1 Is Essential for Retinoid Homeostasis in Murine Skin SRIVASTAVA: Cardiac Fibroblasts Regulate Myocardial Proliferation through beta-1 Integrin Signaling POLLARD: A Genome-Wide Approach to Identifying Novel-Imprinted Genes SRIVASTAVA: miR-126 Regulates Angiogenic Signaling and Vascular Integrity YAMANAKA: Generation of Mouse Induced Pluripotent Stem Cells Without Viral Vectors CONKLIN: WikiPathways: Pathway Editing for the People BRUNEAU: The Developmental Genetics of Congenital Heart Disease YAMANAKA: Generation of Pluripotent Stem Cells from Adult Mouse Liver and Stomach Cells CHARO: A chemokine receptor essential for mobilization of monocytes from bone marrow during hypercholesterolemia
What Makes Us Human? Comparisons of the genomes of humans and chimpanzees are revealing those rare stretches of DNA that are ours alone Katherine S. Pollard's work on what tiny genetic changes say about our evoluation was featured on the cover of the May 2009 issue of Scientific American. See article.	International Society for Stem Cell Research educational video contest winners!!! Mark White, Kathy Ivey, and Josh Arbold created a short educational video, explaining the fundamentals of stem cells, to be used in conjunction with the Gladstone high school and community outreach programs. In addition, this video was selected as the winner of educational stem cell video contest conducted by the ISSCR.
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Research Topics
Atherosclerosis: Cholesterol, Inflammation, and Obesity Genetic Networks in Cardiac Development and Stem Cell Biology Nuclear Reprogramming to Induce Pluripotency
Faculty Recruitment
The Gladstone Instituteof Cardiovascular Diseaseis currently recruiting new faculty in the areas of stem cell and developmental biology and cardiovascular genetics. See posting for further details.