The mission of the Gladstone Institute of Cardiovascular Disease is to contribute to the health and welfare of humankind through research into the causes and prevention of cardiovascular disease.
Director: Deepak Srivastava, M.D. ••• 1650 Owens Street, San Francisco, CA 94158
Tel: (415) 734-2716 ••• Fax: (415) 355-0960 |
Gladstone Scientists Identify Genetic Mechanism Linked to Congenital Heart Disease
January 22, 2012 - Scientists at the Gladstone Institutes have identified a finely tuned mechanism by which fetal heart muscle develops into a healthy and fully formed beating heart—offering new insight into the genetic causes of congenital heart disease and opening the door to one day developing therapies to fight this chronic and potentially fatal disorder. In a paper published online in Nature Genetics, researchers in the laboratory of Benoit Bruneau, Ph.D., describe the role that two genes, Ezh2 and Six1, play in embryonic heart development, while also uncovering how the genetic basis of embyronic heart formation can have profound health consequences later in life.
See press release for details. |
GICD Director Deepak Srivastava Named Fellow of the American Association for the Advancement of Science
December 16, 2011 - The American Association for the Advancement of Science (AAAS) has named Gladstone Senior Investigator Deepak Srivastava, M.D., a Fellow for his efforts to advance science and its application. Dr. Srivastava's studies focus on applying modern genetic and stem cell technologies to identify the causes of human heart disease. He joins five other Gladstone scientists who are already AAAS Fellows: President R. Sanders Williams, M.D.; President Emeritus Robert Mahley, M.D., Ph.D.; Senior Investigator Warner Greene, M.D., Ph.D.; and Senior Investigator Eric Verdin, M.D.
See press release for details. |
BRUNEAU: Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis
POLLARD: A high-resolution map of human evolutionary constraint using 29 mammals
FARESE: Phosphatidylcholine synthesis for lipid droplet expansion is mediated by localized activation of CTP:Phospho-choline cytidyltransferase
SRIVASTAVA: Notch post-translationally regulates beta-catenin protein in stem and progenitor cells
BRUNEAU: Iroquois homeobox gene 3 establishes fast conduction in the cardiac His-Purkinje network
SRIVASTAVA: A genome-wide screen reveals a role for microRNA-1 in modulating cardiac cell polarity
YAMANAKA: Promotion of direct reprogramming by transformation- deficient Myc
BRUNEAU: Chromatin remodeling complex dosage modulates transcription factor function in heart development
POLLARD: A High-throughput procedure quantifies microbial community diversity
CONKLIN: Alternative splicing regulates mouse embryonic stem cell pluripotency and differentiation
SRIVASTAVA: Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors
FARESE: DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation
CHARO: CCR2 mediates hematopoietic stem and progenitor cell trafficking to sites of inflammation in mice
POLLARD: Detection of nonneutral substitution rates on mammalian phylogenies |
Gladstone Scientist Receives American Heart Association Katz Prize for Cardiovascular Research
November 16, 2011 - Li Qian, Ph.D., has won the Louis N. and Arnold M. Katz Basic Science Research Prize for Young Investigators from the American Heart Association, marking the first time that a Gladstone researcher has been the recipient. Dr. Qian is a postdoctoral fellow and CIRM scholar in the laboratory of Dr. Deepak Srivastava.
See press release for details. |
Gladstone Founder Receives American Heart Association Distinguished Scientist Award
November 15, 2011 -The American Heart Association presented Gladstone Institutes Senior Investigator and President Emeritus Robert W. Mahley, M.D., Ph.D., with the 2011 AHA Distinguished Scientist Award, the highest honor that the AHA can give a scientist.
See press release for details. |
Roddenberry Foundation Gives $5 Million to Gladstone
for Stem Cell Research
October 19, 2011 - The Gladstone Institutes and the Roddenberry Foundation inaugurated the Roddenberry Center for Stem Cell Biology and Medicine at Gladstone, a new unit founded on an unprecedented $5 million gift from the foundation that was established to honor the legacy of Star Trek creator Gene Roddenberry.
See press release for details. |
