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1996

Allan CM, Taylor JM (1996) Expression of a novel human apolipoprotein (apoC-IV) causes hypertriglyceridemia in transgenic mice. J. Lipid Res. 37:1510–1518.

Arai H, Charo IF (1996) Differential regulation of G-protein-mediated signaling by chemokine receptors. J. Biol. Chem. 271:21814–21819.

Askanas V, Engel WK, Mirabella M, Weisgraber KH, Saunders AM, Roses AD, McFerrin J (1996) Apolipoprotein E alleles in sporadic inclusion-body myositis and hereditary inclusion-body myopathy. Ann. Neurol. 40:264–265.

Atchison RE, Gosling J, Monteclaro FS, Franci C, Digilio L, Charo IF, Goldsmith MA (1996) Multiple extracellular elements of CCR5 and HIV-1 entry: Dissociation from response to chemokines. Science 274:1924–1926.

Bersot TP, Mahley RW (1996) Clinical classifications of lipid abnormalities. In: Atherosclerosis and Coronary Artery Disease (Fuster V, Ross R, Topol EJ, eds) Lippincott-Raven, Philadelphia, pp 163–169.

Borén J, Lee I, Callow MJ, Rubin EM, Innerarity TL (1996) A simple and efficient method for making site-directed mutants, deletions, and fusions of large DNA such as P1 and BAC clones. Genome Res. 6:1123–1130.

Boring L, Gosling J, Monteclaro FS, Lusis AJ, Tsou C-L, Charo IF (1996) Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1a receptors. Evidence for two closely linked C-C chemokine receptors on chromosome 9. J. Biol. Chem. 271:7551–7558.

Campos H, Arnold KS, Balestra ME, Innerarity TL, Krauss RM (1996) Differences in receptor binding of LDL subfractions. Arterioscler. Thromb. Vasc. Biol. 16:794–801.

Conklin BR, Herzmark P, Ishida S, Voyno-Yasenetskaya TA, Sun Y, Farfel Z, Bourne HR (1996) Carboxyl-terminal mutations of Gqa and Gsa that alter the fidelity of receptor activation. Mol. Pharmacol. 50:885–890.

Connolly AJ, Ishihara H, Kahn ML, Farese RV Jr, Coughlin SR (1996) Role of the thrombin receptor in development and evidence for a second receptor. Nature 381:516–519.

Dang Q, Taylor J (1996) In vivo footprinting analysis of the hepatic control region of the human apolipoprotein E/C-I/C-IV/C-II gene locus. J. Biol. Chem. 271:28667–28676.

Dichek DA, Anderson J, Kelly AB, Hanson SR, Harker LA (1996) Enhanced in vivo antithrombotic effects of endothelial cells expressing recombinant plasminogen activators transduced with retroviral vectors. Circulation 93:301–309.

Dichek D, Schneider DB, Newman KD (1996) Modification of the vascular phenotype by viral gene transfer: Therapy and toxicity. J. Vasc. Surg. 24:163–165.

Dong G, Schulick AH, DeYoung MB, Dichek DA (1996) Identification of a cis-acting sequence in the human plasminogen activator inhibitor type-1 gene that mediates transforming growth factor-b1 responsiveness in endothelium in vivo. J. Biol. Chem. 271:29969–29977.

Dong L-M, Parkin S, Trakhanov SD, Rupp B, Simmons T, Arnold KS, Newhouse YM, Innerarity TL, Weisgraber KH (1996) Novel mechanism for defective receptor binding of apolipoprotein E2 in type III hyperlipoproteinemia. Nat. Struct. Biol. 3:718–722.

Dong L-M, Weisgraber KH (1996) Human apolipoprotein E4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density lipoproteins. J. Biol. Chem. 271:19053–19057.

Dunn PF, Newman KD, Jones M, Yamada I, Shayani V, Virmani R, Dichek DA (1996) Seeding of vascular grafts with genetically modified endothelial cells. Secretion of recombinant TPA results in decreased seeded cell retention in vitro and in vivo. Circulation 93:1439–1446.

Farese RV Jr, Cases S, Ruland SL, Kayden HJ, Wong JS, Young SG, Hamilton RL (1996) A novel function for apolipoprotein B: Lipoprotein synthesis in the yolk sac is critical for maternal–fetal lipid transport in mice. J. Lipid Res. 37:347–360.

Farese RV Jr, Véniant MM, Cham CM, Flynn LM, Pierotti V, Loring JF, Traber M, Ruland S, Stokowski RS, Huszar D, Young SG (1996) Phenotypic analysis of mice expressing exclusively apolipoprotein B48 or apolipoprotein B100. Proc. Natl. Acad. Sci. USA 93:6393–6398.

Fleming LM, Weisgraber KH, Strittmatter WJ, Troncoso JC, Johnson GVW (1996) Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins. Exp. Neurol. 138:252–260.

Fox JEB, Shattil SJ, Kinlough-Rathbone RL, Richardson M, Packham MA, Sanan DA (1996) The platelet cytoskeleton stabilizes the interaction between aIIbb3 and its ligand and induces selective movements of ligand-occupied integrin. J. Biol. Chem. 271:7004–7011.

Franci C, Gosling J, Tsou C-L, Coughlin SR, Charo IF (1996) Phosphorylation by a G protein-coupled kinase inhibits signaling and promotes internalization of the monocyte chemoattractant protein-1 receptor. Critical role of carboxyl-tail serines/threonines in receptor function. J. Immunol. 157:5606–5612.

Gerszten RE, Luscinskas FW, Ding HT, Dichek DA, Stoolman LM, Gimbrone MA Jr, Rosenzweig A (1996) Adhesion of memory lymphocytes to vascular cell adhesion molecule-1–transduced human vascular endothelial cells under simulated physiological flow conditions in vitro. Circ. Res. 79:1205–1215.

Gordon DA, Jamil H, Gregg RE, Olofsson S-O, Borén J (1996) Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. J. Biol. Chem. 271:33047–33053.

Higazi AA-R, Aceto JF, Kniss D, Upson R, Cohen R, Dichek DA, Cines DB (1996) Unesterified long chain fatty acids inhibit the binding of single chain urokinase to the urokinase receptor. Biochemistry 35:6884–6890.

Hirano K-I, Young SG, Farese RV Jr, Ng J, Sande E, Warburton C, Powell-Braxton LM, Davidson NO (1996) Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J. Biol. Chem. 271:9887–9890.

Huang X-Z, Wu JF, Cass D, Erle DJ, Corry D, Young SG, Farese RV Jr, Sheppard D (1996) Inactivation of the integrin b6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lungs and skin. J. Cell Biol. 133:921–928.

Huang Y, Schwendner SW, Rall SC Jr, Mahley RW (1996) Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J. Biol. Chem. 271:29146–29151.

Innerarity TL (1996) Plasma lipoproteins. In: Encyclopedia of Molecular Biology and Biotechnology (Myers RA, ed) VCH Verlagsgesellschaft, Weinheim, Germany, pp 595–606.

Innerarity TL, Borén J, Yamanaka S, Olofsson S-O (1996) Biosynthesis of apolipoprotein B48-containing lipoproteins. Regulation by novel post-transcriptional mechanisms. J. Biol. Chem. 271:2353–2356.

Liu J, Blin N, Conklin BR, Wess J (1996) Molecular mechanisms involved in muscarinic acetylcholine receptor-mediated G protein activation studied by insertion mutagenesis. J. Biol. Chem. 271:6172–6178.

Mahley RW (1996) Heparan sulfate proteoglycan/low density lipoprotein receptor-related protein pathway involved in type III hyperlipoproteinemia and Alzheimer’s disease. Isr. J. Med. Sci. 32:414–429.

Mahley RW, Nathan BP, Bellosta S, Pitas RE (1996) Apolipoprotein E: Structure, function, and possible roles in modulating neurite extension and cytoskeletal activity. In: Apolipoprotein E and Alzheimer’s Disease (Roses AD, Weisgraber KH, Christen Y, eds) Springer-Verlag, Berlin, pp 49–58.

Mahley RW, Nathan BP, Pitas RE (1996) Apolipoprotein E: Structure, function, and possible roles in Alzheimer’s disease. Ann. N.Y. Acad. Sci. 777:139–145.

Mahley RW, Young SG (1996) Hyperlipidemia: Molecular defects of apolipoproteins B and E responsible for elevated blood lipids. In: Molecular Genetics and Gene Therapy of Cardiovascular Disease (Mockrin SC, ed) Marcel Dekker, New York, pp 173–207.

McCormick SPA, Ng JK, Véniant M, Borén J, Pierotti V, Flynn LM, Grass DS, Connolly A, Young SG (1996) Transgenic mice that overexpress mouse apolipoprotein B. Evidence that the DNA sequences controlling intestinal expression of the apolipoprotein B gene are distant from the structural gene. J. Biol. Chem. 271:11963–11970.

McCormick SPA, Peterson KR, Hammer RE, Clegg CH, Young SG (1996) Generation of transgenic mice from yeast artificial chromosome DNA that has been modified by gene targeting. Trends Cardiovasc. Med. 6:16–24.

Meiner VL, Cases S, Myers HM, Sande ER, Bellosta S, Schambelan M, Pitas RE, McGuire J, Herz J, Farese RV Jr (1996) Disruption of the acyl-CoA:cholesterol acyltransferase gene in mice: Evidence suggesting multiple cholesterol esterification enzymes in mammals. Proc. Natl. Acad. Sci. USA 93:14041–4046.

Mirabella M, Alvarez RB, Engel WK, Weisgraber KH, Askanas V (1996) Apolipoprotein E and apolipoprotein E messenger RNA in muscle of inclusion body myositis and myopathies. Ann. Neurol. 40:864–872.

Monteclaro FS, Charo IF (1996) The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1a receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activation. J. Biol. Chem. 271:19084–19092.

Montine TJ, Huang DY, Valentine WM, Amarnath V, Saunders A, Weisgraber KH, Graham DG, Strittmatter WJ (1996) Crosslinking of apolipoprotein E by products of lipid peroxidation. J. Neuropathol. Exp. Neurol. 55:202–210.

Pitas RE (1996) Microtubule formation and neurite extension are blocked by apolipoprotein E4. Semin. Cell Dev. Biol. 7:725–731.

Rade JJ, Schulick AH, Virmani R, Dichek DA (1996) Local adenoviral-mediated expression of recombinant hirudin reduces neointima formation after arterial injury. Nat. Med. 2:293–298.

Raport CJ, Gosling J, Schweickart VL, Gray PW, Charo IF (1996) Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1a. J. Biol. Chem. 271:17161–17166.

Read RC, Zimmerli S, Broaddus VC, Sanan DA, Stephens DS, Ernst JD (1996) The (a2→8)-linked polysialic acid capsule of group B Neisseria meningitidis modifies multiple steps during interaction with human macrophages. Infect. Immun. 64:3210–3217.

Roses AD, Einstein G, Gilbert J, Goedert M, Han S-H, Huang D, Hulette C, Masliah E, Pericak-Vance MA, Saunders AM, Schmechel DE, Strittmatter WJ, Weisgraber KH, Xi P-T (1996) Morphological, biochemical, and genetic support for an apolipoprotein E effect on microtubular metabolism. Ann. N.Y. Acad. Sci. 777:146–157.

Sae-Tung G, Dong J-F, López JA (1996) Biosynthetic defect in platelet glycoprotein IX mutants associated with Bernard-Soulier syndrome. Blood 87:1361–1367.

Weisgraber KH, Dong L-M (1996) Role of apolipoprotein E in Alzheimer’s disease: Clues from its structure. In: Apolipoprotein E and Alzheimer’s Disease (Roses AD, Weisgraber KH, Christen Y, eds) Springer-Verlag, Berlin, pp 11–19.

Weisgraber KH, Mahley RW (1996) Human apolipoprotein E: The Alzheimer’s disease connection. FASEB J. 10:1485–1494.

Welch CL, Xia Y-R, Shechter I, Farese R, Mehrabian M, Mehdizadeh S, Warden CH, Lusis AJ (1996) Genetic regulation of cholesterol homeostasis: Chromosomal organization of candidate genes. J. Lipid Res. 37:1406–1421.

Yamanaka S, Poksay KS, Driscoll DM, Innerarity TL (1996) Hyperediting of multiple cytidines of apolipoprotein B mRNA by APOBEC-1 requires auxiliary protein(s) but not a mooring sequence motif. J. Biol. Chem. 271:11506–11510.

Young SG (1996) Using genetically modified mice to study apolipoprotein B. J. Atheroscler. Thromb. 3:62–74.

Young SG, Krul ES, McCormick S, Farese RV Jr, Linton MF (1996) Identification and characterization of truncated forms of apolipoprotein B in hypobetalipoproteinemia. Methods Enzymol. 263:120–145.

Yu Z, Redfern CS, Fishman GI (1996) Conditional transgene expression in the heart. Circ. Res. 79:691–697.

Zimmerli S, Majeed M, Gustavsson M, Stendahl O, Sanan DA, Ernst JD (1996) Phagosome–lysosome fusion is a calcium-independent event in macrophages. J. Cell Biol. 132:49–61.

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