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Gladstone Scientists Identify Genetic Factors that Hold Promise for Treatment of Vascular Diseases

July 5, 2009—Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) have discovered a key switch that makes stem cells turn into the type of muscle cells that reside in the wall of blood vessels. See press release.

heart heart

What Makes Us Human?
Comparisons of the genomes of humans and chimpanzees are revealing those rare stretches of DNA that are ours alone

Katherine S. Pollard's work on what tiny genetic changes say about our evoluation was featured on the cover of the May 2009 issue of Scientific American. See article.

Scientific American cover

International Society for Stem Cell Research educational video contest winners!!!

Mark White, Kathy Ivey, and Josh Arnold created a short educational video, explaining the fundamentals of stem cells, to be used in conjunction with the Gladstone high school and community outreach programs. This video was selected as the winner of an educational stem cell video contest sponsored by the ISSCR.

Gladstone Scientists Identify Key Factors in Heart Cell Creation

April 26, 2009—Scientists at the Gladstone Institute of Cardiovascular Disease have identified for the first time key genetic factors that drive the process of generating new heart cells. See press release.

mouse embryo mouse embryo

Gladstone's Shinya Yamanaka Wins “Baby Nobel”

April 8, 2009—Shinya Yamanaka, MD, PhD, of the Gladstone Institutes and Kyoto University is one of seven recipients of Canada's prestigious Gairdner Award. The Gairdner is referred to as the “Baby Nobel,” since many winners then go on to win the Nobel Prize. See press release.

Shinya Yamanaka

Gladstone Scientists Find Clues That Guide Division and Expansion of Heart Cells for Regenerative Therapies

SAN FRANCISCO, CA—February 17, 2009—Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California, San Francisco have unraveled a complex signaling process that reveals how different types of cells interact to create a heart. See full press release.

Gladstone Scientists Reveal That Fat Synthesizing Enzyme is Also Key to Healthy Skin and Hair

DGAT1 Regulates Retinoic Acid

SAN FRANCISCO, CA—February 5, 2009—Scientists at the Gladstone Institutes of Cardiovascular Disease (GICD) have found that an enzyme associated with the synthesis of fat in the body is also an element in healthy skin and hair. See press release for details.

Yamanaka Eliminates Viral Vector in Stem Cell Reprogramming

SAN FRANCISCO, CA—October 9, 2008—Shinya Yamanaka MD, PhD, of Kyoto University and the Gladstone Institute of Cardiovascular Disease (GICD) has taken another step forward in improving the possibilities for the practical application of induced pluripotent stem (iPS) cell technology. See press release for details.

Katherine S. Pollard Joins GICD Faculty

Katherine S. Pollard, Ph.D., joined the Gladstone Institute of Cardiovascular Disease as an associate investigator. Her research focuses on analysis of high-dimensonal genomic data. See the Pollard Lab web site for details.

Katie Pollard

The Biology of Fat Storage in Cells

Gladstone research, recently published in Nature, yields new insight into formation of lipid droplets in cells.


Gladstone Scientists Identify Single microRNA That Controls How Heart Chambers Form

SAN FRANCISCO, CA—October 27, 2008—Scientists at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California San Francisco (UCSF) have identified a genetic factor critical to the formation of chambers in the developing heart. The discovery of the role of a microRNA called miR-138, could offer strategies for the treatment of congenital heart defects. See press release for details.

transverse section of zebrafish heart

Gladstone Scientists Identify Single microRNA That Controls Blood Vessel Development

SAN FRANCISCO, CA –August 11, 2008--Scientists from the Gladstone Institute of Cardiovascular Disease (GICD) and UCSF have identified a key regulatory factor that controls development of the human vascular system, the extensive network of arteries, veins, and capillaries that allow blood to reach all tissues and organs. The research, published in the latest issue of Developmental Cell, may offer clues to potential therapeutic targets for a wide variety of diseases, such as heart disease or cancer, that are impacted by or affect the vascular system. See press release.

Developmental Cell journal cover Developmental Cell journal cover - link to article

CIRM Announces New Faculty Awards — Two to Gladstone Investigators

Gladstone investigators Benoit Bruneau and Yadong Huang were among the 23 new recipients of CIRM faculty awards for stem cell research. (PDF of CIRM press release)

Benoit Bruneau and Yadong Huang

Gladstone Scientists Create Wikipathways to Foster Research Collaboration

The laboratory of Bruce Conklin has created a new collaboration tool, WikiPathways to focus on the use of biological pathways.

Wiki Pathways logo

Gladstone and iZumi Bio Announce Partnership

Major research collaboration and licensing agreement to focus on applications for induced pluripotent (iPS) cells.

Logo for iZumi Biotech and photo of J. David Gladstone statue

Shinya Yamanaka Wins Prestigious Shaw Prize

SAN FRANCISCO, CA - June 11, 2008 -- GICD senior investigator recognized for contributions in reprogramming skin cells to pluripotent stem cells. See press release.

Shinya Yamanaka

Gladstone Scientists Identify Role of Tiny RNAs in Controlling Stem Cell Fate

SAN FRANCISCO, CA –March 5, 2008--Researchers at the Gladstone Institute of Cardiovascular Disease (GICD) and the University of California, San Francisco have identified for the first time how tiny genetic factors called microRNAs may influence the differentiation of pluripotent embryonic stem (ES) cells into cardiac muscle. See press release for details.

Download article PDF

Shinya Yamanaka Reprograms Human Adult Cells Into Embryonic-like Stem Cells

SAN FRANCISCO, CA – November 20, 2007 – Acclaimed stem cell researcher Shinya Yamanaka, MD, PhD, has reported that he and his Kyoto University colleagues have successfully reprogrammed human adult cells to function like pluripotent embryonic stem cells. See press release for details.

Shinya Yamanaka, Japan's Leading Stem Cell Scientist, Joins the Gladstone Institutes

Will pursue human applications of his research creating embryonic cells from adult cells

SAN FRANCISCO, CA – August 16, 2007—Acclaimed Japanese stem cell scientist Shinya Yamanaka has joined the Gladstone Institute of Cardiovascular Disease, where he will continue his research into reprogramming adult cells into embryonic stem (ES) cells. See press release for details.

Gladstone Scientists Featured on KQED series Quest

SAN FRANCISCO, CA – May 29, 2007—Dr. Deepak Srivastava, director of the Gladstone Institute of Cardiovascular Disease, is featured in an episode of the TV science series Quest, a production of KQED-TV in San Francisco.

 


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