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Research Milestones
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- Discovered a method to "reprogram" adult cells into embryonic stem-cell-like cells that can be redirected to form any cell type in the body
- Explained fetal heart development and genetic causes of heart disease, providing new methods to turn stem cells or adult cells into beating heart cells
- Helped lay the foundation for the first cholestrol-lowering therapies and for Integrilin, one of the most successful drugs for eliminating the blood clots that can lead to heart attack and stroke
- Discovered a genetic cause of cardiac septal defects (holes in the heart) in humans, the most common cardiac malformation
- Discovered genetic cause of aortic valve disease in humans, the third most common cause of adult heart disease
- Discovered molecular pathway involved in differentiation of cardiomyocytes
- Discovered molecular pathway involved in DiGeorge syndrome, the most common human genetic deletion syndrome
- Determined the protein sequence of apolipoprotein (apo) E and the structural differences in apoE isoforms
- Mapped the low density lipoprotein (LDL) receptor–binding region of apoE
- Determined the apoE cDNA and gene sequence
- Cloned the platelet glycoprotein IIIa
- Determined of the x-ray crystal structure of apoE
- Recognized the role of apoE in neuronal repair and maintenance
- Determined the apoB cDNA sequence
- Mapped the LDL receptor–binding region of apoB
- Established the molecular mechanism of type III hyperlipoproteinemia
- Defined the metabolism and cellular biology of apoB-containing lipoproteins
- Cloned and sequenced the chemokine receptor MCP-1
- Cloned and sequenced ACAT-2, an enzyme involved in intracellular cholesterol homeostasis
- Cloned and sequenced DGAT, an enzyme responsible for triglyceride synthesis
- Generated animal models of human disorders of lipid metabolism
- Determined the role of the Gi signaling pathways in cardiomyopathy
- Used gene-targeting in the artery wall to modify atherosclerosis
- Developed novel animal models of arterial gene transfer and gene therapy
- Studying the genetic epidemiology of low levels of high density lipoproteins (HDL) in the Turkish population
- Defined interactions between the immune system and virus-mediated gene transfer
- Developing a heart-healthy Special Program in Nutrition (SPIN) for third and fourth graders and their families
- Defined the contribution of MCP-1 signaling to the development of atherosclerosis
- Established a role for fractalkine (CX3CR1) in leukocyte adhesion
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