Barbagallo CM, Fan J, Blanche PJ, Rizzo M, Taylor JM, Krauss RM (1999) Overexpression of human hepatic lipase and apoE in transgenic rabbits attenuates response to dietary cholesterol and alters lipoprotein subclass distributions. Arterioscler. Thromb. Vasc. Biol. 19:625–632.

Bersot TP, Vega GL, Grundy SM, Palaoglu KE, Atagündüz P, Özbayrakçi S, Gökdemir O, Mahley RW (1999) Elevated hepatic lipase activity and low levels of high density lipoprotein in a normotriglyceridemic, nonobese Turkish population. J. Lipid Res. 40:432–438.

Bishop GG, Wiegman P, McNamara C, Din S, Sanders J, Hesselbacher S, Feldman M, McPherson JA, Humphries JE, Hammarskjold M-L, Gimple LW, Ragosta M, Powers ER, Dichek D, Owens GK, Sarembock IJ (1999) Local adenovirus-mediated delivery of hirudin in a rabbit arterial injury model. J. Vasc. Res. 36:343–352.

Boring L, Charo IF, Rollins BJ (1999) MCP-1 in human disease. Insights gained from animal models. In: Chemokines in Disease. Biology and Clinical Research (Hébert CA, ed) Humana Press, Totowa, NJ, pp 53–65.

Buttini M, Orth M, Bellosta S, Akeefe H, Pitas RE, Wyss-Coray T, Mucke L, Mahley RW (1999) Expression of human apolipoprotein E3 or E4 in the brains of Apoe^–/– mice: Isoform-specific effects on neurodegeneration. J. Neurosci. 19:4867–4880.

Campbell EM, Charo IF, Kunkel SL, Strieter RM, Boring L, Gosling J, Lukacs NW (1999) Monocyte chemoattractant protein-1 mediates cockroach allergen-induced bronchial hyperreactivity in normal but not CCR2^–/– mice: The role of mast cells. J. Immunol. 163:2160–2167.

Charo IF (1999) CCR2: From cloning to the creation of knockout mice. Chem. Immunol. 72:30–41.

Chen HC, Farese RV Jr (1999) Steroid hormones: Interactions with membrane-bound receptors. Curr. Biol. 9:R478–R481.

Coward P, Chan SDH, Wada HG, Humphries GM, Conklin BR (1999) Chimeric G proteins allow a high-throughput signaling assay of G_i-coupled receptors. Anal. Biochem. 270:242–248.

DeYoung MB, Zamarron C, Lin AP, Qiu C, Driscoll RM, Dichek DA (1999) Optimizing vascular gene transfer of plasminogen activator inhibitor 1. Hum. Gene Ther. 10:1469–1478.

Dichek DA (1999) Interventional approaches to the introduction of genetic material into the cardiovascular system. In: Textbook of Interventional Cardiology, 3rd edition (Topol EJ, ed) WB Saunders, Philadelphia, pp 703–724.

Forstner M, Peters-Libeu C, Contreras-Forrest E, Newhouse Y, Knapp M, Rupp B, Weisgraber KH (1999) Carboxyl-terminal domain of human apolipoprotein E: Expression, purification, and crystallization. Protein Expr. Purif. 17:267–272.

Gillotte KL, Zaiou M, Lund-Katz S, Anantharamaiah GM, Holvoet P, Dhoest A, Palgunachari MN, Segrest JP, Weisgraber KH, Rothblat GH, Phillips MC (1999) Apolipoprotein-mediated plasma membrane microsolubilization. Role of lipid affinity and membrane penetration in the efflux of cellular cholesterol and phospholipid. J. Biol. Chem. 274:2021–2028.

Gosling J, Slaymaker S, Gu L, Tseng S, Zlot CH, Young SG, Rollins BJ, Charo IF (1999) MCP-1 deficiency reduces susceptibility to atherosclerosis in mice that overexpress human apolipoprotein B. J. Clin. Invest. 103:773–778.

Haskell CA, Cleary MD, Charo IF (1999) Molecular uncoupling of fractalkine-mediated cell adhesion and signal transduction. Rapid flow arrest of CX₃CR1-expressing cells is independent of G-protein activation. J. Biol. Chem. 274:10053–10058.

Hersberger M, Patarroyo-White S, Arnold KS, Innerarity TL (1999) Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3′ efficiency element. J. Biol. Chem. 274:34590–34597.

Herz J, Farese RV Jr (1999) The LDL receptor gene family, apolipoprotein B and cholesterol in embryonic development. J. Nutr. 129:473S–475S.

Huang Y, Ji Z-S, Brecht WJ, Rall SC Jr, Taylor JM, Mahley RW (1999) Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic VLDL production and impairing VLDL lipolysis. Arterioscler. Thromb. Vasc. Biol. 19:2952–2959.

Huang Y, Mahley RW (1999) Apolipoprotein E and human disease. In: Plasma Lipids and Their Role in Disease (Barter PJ, Rye K-A, eds) Harwood Academic Publishers, Amsterdam, pp 257–284.

Jung HR, Turner SM, Neese RA, Young SG, Hellerstein MK (1999) Metabolic adaptations to dietary fat malabsorption in chylomicron-deficient mice. Biochem. J. 343:473–478.

Kim E, Ambroziak P, Otto JC, Taylor B, Ashby M, Shannon K, Casey PJ, Young SG (1999) Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. J. Biol. Chem. 274:8383–8390.

Kim E, Lowenson JD, Clarke S, Young SG (1999) Phenotypic analysis of seizure-prone mice lacking L-isoaspartate (D-aspartate) O-methyltransferase. J. Biol. Chem. 274:20671–20678.

Mahley RW, Bersot TP (1999) Low levels of high-density lipoproteins in the Turkish population: A risk factor for coronary heart disease. Arch. Turk. Soc. Cardiol. 27:37–43.

Mahley RW, Huang Y (1999) Apolipoprotein E: From atherosclerosis to Alzheimer’s disease and beyond. Curr. Opin. Lipidol. 10:207–217.

Mahley RW, Huang Y, Rall SC Jr (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): Questions, quandaries, and paradoxes. J. Lipid Res. 40:1933–1949.

Mahley RW, Ji Z-S (1999) Remnant lipoprotein metabolism: Key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E. J. Lipid Res. 40:1–16.

Mahley RW, Rall SC Jr (1999) Is e4 the ancestral human apoE allele? Neurobiol. Aging 20:429–430.

Mahley RW, Rall SC Jr (1999) Type III hyperlipoproteinaemia (dysbetalipoproteinaemia; remnant particle disease). In: Lipoproteins in Health and Disease (Betteridge DJ, Illingworth DR, Shepherd J, eds) Arnold, London, pp 719–736.

Morrow JA, Arnold KS, Weisgraber KH (1999) Functional characterization of apolipoprotein E isoforms overexpressed in Escherichia coli. Protein Expr. Purif. 16:224–230.

Nielsen LB, McCormick SPA, Young SG (1999) A new approach for studying gene regulation by distant DNA elements in transgenic mice. Expression of bacterial artificial chromosomes modified by RARE cleavage reveals that apolipoprotein B gene expression in the intestine is controlled by DNA sequences located more than 50 kb 5′ to the structural gene. Scand. J. Clin. Lab. Invest. 59 (Suppl. 229):33–40.

Nielsen LB, Sullivan M, Vanni-Reyes T, Goldberg IJ, Young SG (1999) The DNA sequences required for apolipoprotein B expression in the heart are distinct from those required for expression in the intestine. J. Mol. Cell. Cardiol. 31:695–703.

Orth M, Weng W, Funke H, Steinmetz A, Assmann G, Nauck M, Dierkes J, Ambrosch A, Weisgraber KH, Mahley RW, Wieland H, Luley C (1999) Effects of a frequent apolipoprotein E isoform, apoE4_Freiburg(Leu28→Pro), on lipoproteins and the prevalence of coronary artery disease in whites. Arterioscler. Thromb. Vasc. Biol. 19:1306–1315.

Otto JC, Kim E, Young SG, Casey PJ (1999) Cloning and characterization of a mammalian prenyl protein-specific protease. J. Biol. Chem. 274:8379–8382.

Raabe M, Véniant MM, Sullivan MA, Zlot CH, Björkegren J, Nielsen LB, Wong JS, Hamilton RL, Young SG (1999) Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice. J. Clin. Invest. 103:1287–1298.

Rade JJ, Cheung M, Miyamoto S, Dichek DA (1999) Retroviral vector-mediated expression of hirudin by human vascular endothelial cells: Implications for the design of retroviral vectors expressing biologically active proteins. Gene Ther. 6:385–392.

Raffaï R, Vukmirica J, Weisgraber KH, Rassart E, Innerarity TL, Milne R (1999) Bacterial expression and purification of the Fab fragment of a monoclonal antibody specific for the low-density lipoprotein receptor-binding site of human apolipoprotein E. Protein Expr. Purif. 16:84–90.

Redfern CH, Coward P, Degtyarev MY, Lee EK, Kwa AT, Hennighausen L, Bujard H, Fishman GI, Conklin BR (1999) Conditional expression and signaling of a specifically designed G_i-coupled receptor in transgenic mice. Nat. Biotechnol. 17:165–169.

Reid S, Ritchie A, Boring L, Gosling J, Cooper S, Hangoc G, Charo IF, Broxmeyer HE (1999) Enhanced myeloid progenitor cell cycling and apoptosis in mice lacking the chemokine receptor, CCR2. Blood 93:1524–1533.

Rozek A, Sparrow JT, Weisgraber KH, Cushley RJ (1999) Conformation of human apolipoprotein C-I in a lipid-mimetic environment determined by CD and NMR spectroscopy. Biochemistry 38:14475–14484.

Schneider DB, Sassani AB, Vassalli G, Driscoll RM, Dichek DA (1999) Adventitial delivery minimizes the proinflammatory effects of adenoviral vectors. J. Vasc. Surg. 29:543–550.

Schneider WJ, Young SG (1999) Genetics and molecular biology. Curr. Opin. Lipidol. 10:85–87.

Stafforini DM, Tjoelker LW, McCormick SPA, Vaitkus D, McIntyre TM, Gray PW, Young SG, Prescott SM (1999) Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. J. Biol. Chem. 274:7018–7024.

Terasawa Y, Cases SJ, Wong JS, Jamil H, Jothi S, Traber MG, Packer L, Gordon DA, Hamilton RL, Farese RV Jr (1999) Apolipoprotein B-related gene expression and ultrastructural characteristics of lipoprotein secretion in the mouse yolk sac during embryonic development. J. Lipid Res. 40:1967–1977.

Trakhanov S, Parkin S, Raffaï R, Milne R, Newhouse YM, Weisgraber KH, Rupp B (1999) Structure of a monoclonal 2E8 Fab antibody fragment specific for the low-density lipoprotein-receptor binding region of apolipoprotein E refined at 1.9 Å. Acta Crystallogr. D 55:122–128.

Vassalli G, Agah R, Qiao R, Aguilar C, Dichek DA (1999) A mouse model of arterial gene transfer. Antigen-specific immunity is a minor determinant of the early loss of adenovirus-mediated transgene expression. Circ. Res. 85:e25–e32.

Véniant MM, Kim E, McCormick S, Borén J, Nielsen LB, Raabe M, Young SG (1999) Insights into apolipoprotein B biology from transgenic and gene-targeted mice. J. Nutr. 129:451S–455S.

Véniant MM, Nielsen LB, Borén J, Young SG (1999) Lipoproteins containing apolipoprotein B-100 are secreted by the heart. Trends Cardiovasc. Med. 9:103–107.

Warmington KS, Boring L, Ruth JH, Sonstein J, Hogaboam CM, Curtis JL, Kunkel SL, Charo IF, Chensue SW (1999) Effect of C–C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation. Analysis of cellular recruitment and cytokine responses. Am. J. Pathol. 154:1407–1416.

Young SG, Fielding CJ (1999) The ABCs of cholesterol efflux. Nat. Genet. 22:316–318.

Young SG, Lusis AJ, Hammer RE (1999) Genetically modified animal models in cardiovascular research. In: Molecular Basis of Cardiovascular Disease. A Companion to Braunwald’s Heart Disease. (Chien KR, Breslow JL, Leiden JM, Rosenberg RD, Seidman CE, eds) WB Saunders, Philadelphia, pp 37–85.

Zlot CH, Flynn LM, Véniant MM, Kim E, Raabe M, McCormick SPA, Ambroziak P, McEvoy LM, Young SG (1999) Generation of monoclonal antibodies specific for mouse apolipoprotein B-100 in apolipoprotein B-48-only mice. J. Lipid Res. 40:76–84.

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