Gladstone spacer GICD
 
 
Supporting Gladstone
Publications 2009

  1. Ahmad ST, Sweeney ST, Lee J-A, Sweeney NT, Gao F-B (2009) A genetic screen identifies Serpin5 as a regulator of the Toll pathway and CHMP2B toxicity associated with frontotemporal dementia. Proc. Nat. Acad. Sci. USA. 106:12168–12173.

  2. Cheng JS, Dubal DB, Kim DH, Legleiter J, Cheng IH, Yu G.-Q, Tesseur I, Wyss-Coray T, Bonaldo P, Mucke L (2009) Collagen VI protects neurons against Aβ toxicity. Nat. Neurosci. 12:119–121.

  3. Cisse M and Mucke L (2009) Alzheimer's disease: A prion protein connection. Nature 457:1090–1091.

  4. Daub A, Sharma P, Finkbeiner S (2009) High-content screening of primary neurons: ready for prime time. Curr. Opin. Neurobiol. 19(5):537–543.

  5. Friedman B, Schachtrup C, Tsai PS, Shih AY, Akassoglou K, Kleinfeld D, Lyden PD (2009) Acute vascular disruption and aquaporin 4 loss after stroke. Stroke 40:2182–2190.

  6. Gaultier A, Wu X, Le Moan N, Takimoto S, Mukandala S, Akassoglou K, Campana MW, Gonias SL (2009) Low Density Lipoprotein Receptor-related Protein-1 is an essential receptor for myelin phagocytosis. J. Cell Sci. 122:1155–1162.

  7. Giorgini F, Muchowski PJ (2009) Exploiting yeast genetics to inform therapeutic strategies for Huntington's disease. Methods Mol. Biol. 548:161–174.

  8. Gu X, Greiner ER, Mishra R, Kodali R, Osmand A, Finkbeiner S, Steffan JS, Thompson LM, Wetzel R, Yang XW (2009) Ser13 and Ser16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice. Neuron. 64(6):828–840.

  9. Hatters DM, Voss JC, Budamagunta MS, Newhouse YN, Weisgraber KH (2009) Insight on the molecular envelope of lipid-bound apolipoprotein E from electron paramagnetic resonance spectroscopy. J. Mol. Biol. 386:261–271.

  10. Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, Deves A, Ferris S, Greenberg BD, Johnson C, Kukull WA, Poirier J, Schenk D, Thies W, Gauthier S, Gilman S, Bernick C, Cummings JL, Fillit H, Grundman M, Kaye J, Mucke L, Reisberg B, Sano M, Pickeral O, Petersen RC, Mohs RC, Carrillo M, Corey-Bloom JP, Foster NL, Jacobsen S, Lee V, Potter WZ, Sabbagh MN, Salmon D, Trojanowski JQ, Wexler N, Bain LJ (2009) A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimer's Dement. 5:85–92.

  11. Kreitzer AC (2009) Physiology and pharmacology of striatal neurons. Annu. Rev. Neurosci. 32:127–147.

  12. Lee J-A, Gao F-B (2009) ESCRT, autophagy, and frontotemporal dementia. BMB Reports 41:827–832.

  13. Lee J-A, Gao F-B (2009) Inhibition of autophagy induction delays neuronal cell loss caused by dysfunctional ESCRT-III in frontotemporal dementia. J. Neurosci. 29:8506–8511.

  14. Lee J-A, Liu L, Gao F-B (2009) Autophagy defects contribute to dysfunctional ESCRT-III-induced neurodegeneration. Autophagy 5:1070–1072.

  15. Legleiter J, Lotz GP, Miller J, Ko J, Ng C, Williams GL, Finkbeiner S, Patterson PH, Muchowski PJ (2009) Monoclonal antibodies recognize distinct conformational epitopes formed by polyglutamine in a mutant huntingtin fragment. J. Biol. Chem. 284:21647–21658.

  16. Li G, Bien-Ly N, Andrews-Zwilling Y, Xu Q, Bernardo A, Ring K, Halabisky B, Deng C, Mahley RW, Huang Y (2009) GABAergic interneuron dysfunction impairs hippocampal neurogenesis in adult apolipoprotein E4 knockin mice. Cell Stem Cell 5(6):634–645.

  17. Lu Y, Ferris J, Gao F-B (2009) Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching. Mol. Brain 2:30.

  18. Lu Y*, Wang F*, Li Y*, Ferris J, Lee J-A, Gao F-B (2009) The Drosophila homologue of the Angelman syndrome ubiquitin ligase regulates the formation of terminal dendritic branches. Hum. Mol. Genet. 18:454–462.

  19. Mahley RW, Huang Y (2009) Alzheimer disease: multiple causes, multiple effects of apolipoprotein E4, and multiple therapeutic approaches. Ann. Neurol. 65:623-625.

  20. Mahley RW, Weisgraber KH, Huang Y. (2009) Apolipoprotein E: Structure determines functionófrom atherosclerosis to Alzheimer's disease to AIDS. J. Lipid Res. 50:S183–S188.

  21. Meilandt WJ, Cisse M, Ho K, Wu T, Esposito LA, Scearce Levie K, Cheng IH, Yu G.-Q, Mucke L (2009) Neprilysin overexpression inhibits plaque formation but fails to reduce pathogenic Aβ oligomers and associated cognitive deficits in human amyloid precursor protein transgenic mice. J. Neurosci. 29:1977–1989.

  22. Miller J, Rutenber E, Muchowski PJ (2009) Polyglutamine dances the conformational cha-cha-cha. Structure 17:1151–1153.

  23. Mitra S, Tsvetkov AS, Finkbeiner S (2009) Protein turnover and inclusion body formation. Autophagy 5(7):1037–1038.

  24. Mitra S, Tsvetkov A, Finkbeiner S (2009) Single neuron ubiquitin-proteasome dynamics accompanying inclusion body formation in Huntington's disease. J. Biol. Chem. 284:4398–4403.

  25. Montie HL, Cho MS, Holder L, Liu Y, Tsvetkov AS , Finkbeiner S, Merry DE (2009) Cytoplasmic retention of polyglutamine-expanded androgen receptor ameliorates disease via autophagy in a mouse model of spinal and bulbar muscular atrophy. Hum. Mol. Genet. 18:1937–1950.

  26. Muccioli GG, Sia A, Muchowski PJ, Stella N (2009) Genetic manipulation of palmitoylethanolamide production and inactivation in Saccharomyces cerevisiae. PLoS One 4(6):e5942.

  27. Mucke L (2009) Neuroscience:Alzheimer's disease. Nature 461(7266):895–897.

  28. Palop JJ and Mucke L (2009) Epilepsy and cognitive impairments in Alzheimer disease. Arch. Neurol. 66:435–440.

  29. Pintchovski SA, Peebles CL, Kim HJ, Verdin E, Finkbeiner S (2009) The serum response factor and a putative novel transcription factor regulate expression of the immediate-early gene Arc/Arg3.1 in neurons.J. Neurosci. 29:1525–1537.

  30. Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S (2009) Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. ScientificWorldJournal 18;9:1321–1344.

  31. Ryu JK, Davalos D, Akassoglou K (2009) Fibrinogen signal transduction in the nervous system. J. Thromb. Haemost. 7 Suppl 1:151–154.

  32. Sun B, Halabisky B, Zhou Y, Yu G, Mucke L, Gan L (2009) Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease. Cell Stem Cell. 5(6):624–633.

  33. Tesseur I, Zhang H, Brecht W, Corn J, Gong J.-Sheng, Yanagisawa K, Michikawa M, Weisgraber K, Huang Y, Wyss-Coray T (2009) Bioactive TGF- β can associate with lipoproteins and is enriched in those containing apolipoprotein E3. J. Neurochemistry 110:1254–1262.

  34. Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS (2009) IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. J. Cell Biol. 187(7):1083–1099.

  35. Tsvetkov AS, Mitra S, Finkbeiner S (2009) Protein turnover differences between neurons and other cells. Autophagy. 5:1–3.

  36. Wacker JL, Huang SY, Steele AD, Aron R, Lotz GP, Nguyen Q, Giorgini F, Roberson ED, Lindquist S, Masliah E, Muchowski PJ (2009) Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease. J Neurosci. 29(28):9104-9114.

  37. Zhong N, Ramaswamy G, Weisgraber KH (2009) Apolipoprotein E4 domain interaction induces endoplasmic reticulum stress and impairs astrocyte function. J. Biol. Chem. 284:27273–27280.

  38. Zhong N, Weisgraber KH (2009) Understanding the association of apoE4 with Alzheimer's disease. Clues from its structure. J. Biol. Chem. 284:6027–6031.

  39. Zhong N, Weisgraber KH. Understanding the basis for the association of apoE4 with Alzheimer's disease: Opening the door for therapeutic approaches. Current Alzheimer Research. Supp. 9th International Conference on Alzheimer's Drug Discovery. 6:415ñ418.

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