Gladstone Institute of Neurological Disease -

Lennart Mucke, M.D.
Director
Gladstone Institute of Neurological Disease
Joseph B. Martin Distinguished Professor of Neuroscience
University of California, San Francisco
Interests/Approaches: Alzheimer's disease, amyloid proteins, mechanisms of neurodegeneration, cognitive functions and their disruption by disease, glia, preclinical assessment of novel therapeutic strategies, transgenic models.

Katerina Akassoglou, Ph.D.
Associate Investigator
Gladstone Institute of Neurological Disease
Associate Professor of Neurology
University of California, San Francisco
Interests/Approaches: Neurovascular communication, Multiple Sclerosis, BBB disruption, fibrinogen, inflammation, microglia, in vivo multiphoton imaging, p75 neurotrophin receptor signaling and functions, extracellular matrix, tissue repair

Steven M. Finkbeiner, M.D., Ph.D.
Associate Director and Senior Investigator
Gladstone Institute of Neurological Disease
Professor of Neurology and Physiology
University of California, San Francisco
Interests/Approaches: astroglial-neuronal communication, calcium imaging, confocal microscopy, Huntington's disease, gene gun, neuroplasticity, neurotrophins, organotypic cultures, trinucleotide-repeat diseases.

Li Gan, Ph.D.
Associate Investigator
Gladstone Institute of Neurological Disease
Assistant Professor of Neurology
University of California, San Francisco
Interests/Approaches: Alzheimer's disease, microglial-neuronal interaction, RNA interference, gene silencing, viral vector-mediated gene transfer, neurodegeneration, transgenic models, preclinical validation of novel therapeutic targets

Yadong Huang, M.D., Ph.D.
Associate Investigator
Gladstone Institute of Neurological Disease
Associate Professor of Pathology and Neurology
University of California, San Francisco
Interests/Approaches: Alzheimer's disease, apoE, brain lipid metabolism, cytoskeletal structure and function, neurodegeneration, proteases, protease inhibitors, tau protein, transgenic models.

Anatol Kreitzer, Ph.D.
Assistant Investigator
Gladstone Institute of Neurological Disease
Assistant Professor of Physiology and Neurology
University of California, San Francisco
Interests/Approaches: Basal ganglia, dopamine, electrophysiology, endocannabinoids, Huntington's disease, movement disorders, neural circuits and behavior, optical imaging, Parkinson's disease, striatum, synaptic plasticity.

Robert W. Mahley, M.D., Ph.D.
President Emeritus, The J. David Gladstone Institutes
Senior Investigator, Gladstone Institute of Neurological Disease
Professor of Pathology and Medicine
University of California, San Francisco
Interests/Approaches: Alzheimer's disease, apoE, cell biology, cytoskeleton, DNA chips, lipid transport, proteoglycans.

Paul Muchowski, Ph.D.
Associate Investigator
Gladstone Institute of Neurological Disease
Associate Professor of Biochemistry, Biophysics, and Neurology
University of California, San Francisco
Interests/Approaches: Protein misfolding, mechanisms of neurodegeneration, yeast genetic and chemical-genetic screens, atomic force microscopy, chaperone proteins.

Ken Nakamura, M.D., Ph.D.
Assistant Investigator
Gladstone Institute of Neurological Disease
Assistant Professor of Neurology
University of California, San Francisco
Interests/Approaches: Mitochondria, Parkinson's disease, dopamine, Alzheimer's disease, mechanisms of neurodegeneration, movement disorders, cell biology, neuronal cultures, optical imaging, purified proteins, transgenic models.

Jorge J. Palop, Ph.D.
Staff Research Investigator
Gladstone Institute of Neurological Disease
Assistant Professor of Neurology
University of California, San Francisco
Interests/Approaches: Alzheimer's disease, amyloid beta, mechanisms of amyloid beta-induced cognitive deficits and network dysfunction, epileptiform activity and seizures, hippocampal remodeling, transgenic models of Alzheimer's disease, behavior, EEG recordings, physiology, pharmacology, genetic manipulations.