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Publications 2008
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- Burt TD, Agan BK, Marconi VC, He W, Kulkarni H, Mold JE, Cavrois M, Huang Y, Mahley RM, Dolan MJ, McCune JM, Ahuja SK (2008) Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE ε4/ε4 genotype accelerates HIV disease progression. Proc. Natl. Acad. Sci. USA 105:8718–8723.
- Cavrois M, Neidleman J, Greene WC (2008) The achilles heel of the Trojan horse model of HIV trans-infection. PLoS Pathog. 4:e1000051.
- Chiu Y-L, Greene WC (2008) The APOBEC3 cytidine deaminases: An innate defensive network opposing exogenous retroviruses and endogenous retroelements. Ann. Rev. Immunol. 26:317–353.
- Erickson AL, Willberg CB, McMahan V, Liu A, Buchbinder SP, Grohskopf LA, Grant RM, Nixon DF (2008) Potentially exposed but uninfected individuals produce cytotoxic and polyfunctional human immunodeficiency virus type 1-specific CD8(+) T-cell responses which can be defined to the epitope level. Clin. Vaccine Immunol. 15:1745-1748.
- Fauci AS, Johnston MI, Dieffenbach CW, Burton DR, Hammer SM, Hoxie JA, Martin M, Overbaugh J, Watkins DI, Mahmoud A, Greene WC (2008) HIV Vaccine Research: The Way Forward. Science 321:530–532.
- Grant RM, Hamer D, Hope T, Johnston R, Lange J, Lederman MM, Lieberman J, Miller CJ, Moore JP, Mosier DE, Richman DD, Schooley RT, Springer MS, Veazey RS, Wainberg MA (2008) Whither or wither microbicides? Science 321:532–534.
- Greene WC, Debyser Z, Ikeda Y, Freed EO, Stephens E, Yonemoto W, Buckheit RW, Este JA, Cihlar T. Novel targets for HIV therapy. Antiviral Res. 80:251–265.
- Kwon H-S, Brent MM, Getachew R, Jayakumar P, Chen L-F, Schnolzer M, McBurney MW, Marmorstein R, Greene WC, Ott M (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe 3:158–167.
- Kwon H-S, Ott M (2008) The ups and downs of SIRT1. Trends Biochem. Sci. 33:517–525.
- Lee AW, Sharp ER, O'Mahony A, Rosenberg MG, Israelski DM, Nolan GP, Nixon DF (2008) Single-cell, phosphoepitope-specific analysis demonstrates cell type- and pathway-specific dysregualtion of Jak/STAT and MAPK signaling associated with in vivo human immunodeficiency virus type 1 infection. J. Virol. 82:3702–3712.
- McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Oxford C, Evans TG, Asmuth DM (2008) Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part I: Panel design by an empiric approach. Cytometry A 73:400–410.
- McLaughlin BE, Baumgarth N, Bigos M, Roederer M, De Rosa SC, Altman JD, Nixon DF, Ottinger J, Li J, Beckett L, Shacklett BL, Evans TG, Asmuth DM (2008) Nine-color flow cytometry for accurate measurement of T cell subsets and cytokine responses. Part II: Panel performance across different instrument platforms. Cytometry A 73:411–420.
- Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH (2008) Optical reporters for the conformation of α-synuclein reveal a specific interaction with mitochondria. J. Neurosci.
28:12305–12317.
- Napolitano LA, Schmidt D, Gotway M, Ameli N, Filbert EL, Ng MM, Clor JL, Epling L, Sinclair E, Baum PD, Li K, Killian ML, Bacchetti P, McCune JM (2008) Growth Hormone Enhances Thymic Function in HIV-1–infected Adults. J. Clin. Invest. 118:1085–1098.
- Neugebauer RC, Uchiechowska U, Meier R, Hruby H, Valkov V, Verdin E, Sippi W, Jung M (2008) Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode. J. Med. Chem. 51:1203–1213.
- Santiago ML, Greene WC (2008) The role of the APOBEC3 family of cytidine deaminases in innate immunity, G-to-A hypermutation, and evolution of retroviruses. In: Origin and Evolution of Viruses (E. Domingo, C. Parrish, J.L. Holland, eds.) Elsevier Publishers, Boston, MA, pp. 183–205.
- Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC (2008) APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343–1346. DOI: 10.1126/science.1161121
- Schäfer S, Saunders L, Eliseeva E, Velena A, Jung M, Schwienhorst A, Strasser A, Diskmanns A, Ficner R, Schlimme S, Sippl W, Verdin E, Jung M (2008) Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg. Med. Chem. 16:2011–2033.
- Schwer B, Verdin E (2008) Conserved metabolic regulatory functions of sirtuins. Cell Metab. 7:104–112.
- Scott GK, Marx C, Berger CE, Saunders LR, Verdin E, Schäfer S, Jung M, Benz CC (2008) Destabilization of ERBB2 transcripts by targeting 3' UTR mRNA-associated HuR and histone deacetylase-6 (HDAC6). Mol. Cancer Res. 6:1250–1258.
- Strickler HD, Fazzari M, Kovacs A, Isasi C, Napolitano LA, Minkoff H, Gange S, Young M, Sharp GB, Kaplan RC, Cohen M, Gunter MJ, Harris TG, Yu H, Schoenbaum E, Landay AL, Anastos K (2008) Associations of insulin-like growth factor-1 (IGF-1) and IGF binding protein-3 with HIV disease progression in women. J. Inf. Dis. 197:319–327.
- Truong HM, Kellogg T, Schwarcz S, Delgado V, Grant RM, Louie B, Ngo H, McFarland W (2008) Frequent international travel by men who have sex with men recently diagnosed with HIV-1: Potential for transmission of primary HIV-1 drug resistance. J. Travel Med. 15:454–456.
- Uciechowska U, Schemies J, Neugebauer RC, Huda EM, Schmitt ML, Meier R, Verdin E, Jung M, Sippl W (2008) Thiobarbiturates as sirtuin inhibitors: Virtual screening, free-energy calculations, and biological testing. Chem. Med. Chem. 3:1965-1976.
- Wang S, Li X, Parra M, Verdin E, Bassel-Duby R, Olson EN (2008) Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7. Proc. Natl. Acad. Sci. USA 105:7738–7743.
- Willberg CB, McConnell JJ, Eriksson EM, Bragg LA, York VA, Liegler TJ, Hecht FM, Grant RM, Nixon DF (2008) Immunity to HIV-1 is influenced by continued natural exposure to exogenous virus. PLoS Pathog. 4:e1000185.
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