Focus: Studies of the molecular basis for HIV pathogenesis, transmission, and latency and the biochemical mechanisms underlying the regulation and action of the NF-κB/Rel family of eukaryotic transcription factors.

Focus: Studies of RNA biology underlying the innate immunity opposing retrotransposition, the biological actions of RNA granules in mammalian cells and miRNA-mediated gene regulation during viral pathogenesis.

Focus: Studies of HIV genetic diversity, the causes and consequences of drug failure in HIV infection, optimization of antiretroviral therapy based on assessment of viral genotype and phenotype, studies of HIV superinfection, and assessment of HIV replication/latency in different tissue sanctuaries.

Focus: Studies of positive regulators of thymopoiesis, investigation of mechanisms regulating T cell production and immune reconstitution in human immunodeficiency, evaluation of the effects of regulators of thymopoiesis in human clinical trials.

Focus: Molecular mechanisms of HIV-1 Tat function, including its reversible acetylation; biology of hepatitis C virus infection with a focus on the core protein.

Focus: Mechanism by which HIV establishes viral latency, characterization of natural Tat-inhibitory factors, and the biochemistry and function of class 1,2, and 3 histone deacetylases in normal cell biology.