Warner C. Greene, M.D. Ph.D. -

Selected Recent Publications

Doitsh G, Cavrois M, Lassen KG, Zepeda O, Yang Z, Santiago ML, Hebbler AM, Greene WC (2010) Abortive HIV infection mediates CD4 T-cell depletion and inflammation in human lymphoid tissue. Cell 143:789–801.

Roan NR, Münch J, Arhel N, Mothes W, Neidleman J, Kobayashi A, Smith-McCune K, Kirchhoff F, Greene WC (2009) The cationic properties of SEVI underlie its ability to enhance human immunodeficiency virus infection. J. Virol. 83:73–80.

Richman DD, Margolis DM, Delaney M, Greene WC, Hazuda D, Pomerantz RJ (2009) The challenge of finding a cure for HIV infection. Science 323:1304–1307.

Santiago ML, Montano M, Benitez R, Messer RJ, Yonemoto W, Chesebro B, Hasenkrug KJ, Greene WC (2008) APOBEC3 encodes Rfv3, a gene influencing neutralizing antibody control of retrovirus infection. Science 321:1343–1346.

Cavrois M, Neidleman J, Greene WC (2008) The Achilles heel of the Trojan horse model of HIV trans-infection. PLoS Path. 4:e1000051.

Chiu Y-L, Greene WC (2008) The APOBEC3 cytidine deaminases: An innate defensive network opposing exogenous retroviruses and endogenous retroelements. Ann. Rev. Immunol. 26:317–353.

Greene WC (2007) A history of AIDS: Looking back to see ahead. Eur. J. Immunol. 37:S94–102.

Roan NR, Greene WC (2007) A seminal finding for understanding HIV transmission. Cell 131:1044–1026.

Williams SA, Kwon H, Chen L-F, Greene WC (2007) Sustained induction of NF-kB is required for efficient expression of latent HIV-1. J. Virol. 81:6043–6056.

Chen L-f, Greene WC (2007) Regulation of nuclear NF-kB action: A key role for post-translational modification. In: Handbook of Transcription Factor NF-kB (Ghosh S, ed.), CRC Press, Boca Raton, FL, pp. 87–105.

de Noronha C, Greene WC (2007) Retroviruses and the Nucleus. In: Hiscox JA (Ed.), Viruses and the Nucleus, John Wiley & Sons, Ltd., Chicester, UK, pp 89–128.

Greene WC (2007) Molecular biology of HIV: Implications for new therapies. In: Global HIV/AIDS Medicine (Sande M, Lange J, Volberding P, Greene WC, eds.), Elsevier, Philadelphia, pp. 23–38.

Soros VB, Yonemoto W, Greene WC (2007) Newly synthesized APOBEC3G is incorporated into HIV virions, inhibited by HIV RNA, and subsequently activated by RNase H. PLoS Path. 3:e15.

Cavrois M, Neidleman J, Kreisberg JF, Greene WC (2007) In vitro derived dendritic cells trans-infect CD4 T cells primarily with surface-bound HIV-1 virions. PLoS Path. 3:e4.

Stopak KS, Chiu Y-L, Kropp J, Grant RM, Greene WC (2007) Distinct patterns of cytokine regulation of APOBEC3G expression and activity in primary lymphocytes, macrophages, and dendritic cells. J. Biol. Chem. 282:3539–3546.

Chiu YL, Witkowska HE, Hall SC, Santiago M, Soros VB, Esnault C, Heidmann T, Greene WC (2006) High-molecular mass APOBEC3G complexes restrict Alu retrotransposition. PNAS 103:15588–15593.

Zimmerman ES, Sherman MP, Blackett JL, Neidleman JA, Kreis C, Mundt P, Williams SA, Warmerdam M, Kahn J, Hecht FM, Grant RM, de Noronha CMC, Weyrich AS, Greene WC, Planelles V (2006) HIV-1 Vpr induces DNA replication stress in vitro and in vivo. J. Virol. 80:10407–10418.

Chandrasekar B, Mummidi S, Mahimainathan L, Pael DN, Bailey SR, Imam SZ, Greene WC, Valente AJ (2006) Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kB– and AP-1–mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. J. Biol. Chem. 281:15099–15109.

O'Mahony A, Raber J, Foehr E, Montano M, Han V, Lu S, Kwon H, LeFevour A, Chakraborty-Sett S, Greene WC (2006) NF-kB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity. Mol. Cell Biol. 26:7283–7298.

Soros VB, Greene WC (2006) APOBEC3G and HIV-1: Strike and Counterstrike. Curr. Inf. Dis. Rep. 8:317–323.

Chiu Y-L, Greene WC (2006) Multifaceted antiviral actions of APOBEC3 cytidine deaminases. Trends Immunol. 27:291–297.

Kreisberg JF, Yonemoto W, Greene WC (2006) Endogenous factors enhance HIV infection of tissue naive CD4 T cells by stimulating high-molecular-mass APOBEC3G complex formation. J. Exp. Med. 203:865–870.

Cavrois M, Neidleman J, Kreisberg JF, Fenard D, Callebaut C, Greene WC (2006) Human immunodeficiency virus fusion to dendritic cells declines as cells mature. J. Virol. 80:1992–1999.

Chiu Y-L, Greene WC (2006) APOBEC3 cytidine deaminases: Distinct antiviral actions along the retroviral life cycle. J. Biol. Chem. 281:8309–8312.

Williams SA, Chen L-f, Kwon H, Ruiz-Jarabo CM, Verdin E, Greene WC (2006) NF-kB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. EMBO J. 25:139–149.

Greene WC (2004) The brightening future of HIV therapeutics. Nat. Immunol. 5:867–871.

Stopak K, de Noronha C, Yonemoto W, Greene WC (2003) HIV-1 Vif blocks the antiviral activity of APOBEC3G by impairing both its translation and intracellular stability. Mol. Cell 12:591–601.

Chen LF, Mu Y, Greene WC (2002) Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kB. EMBO J. 21:6539–6548.

Greene WC, Peterlin BM (2002) Charting HIV's remarkable voyage through the cell: Basic science as a passport to future therapy. Nat. Med. 8:673–680.

Chen L-f, Fischle W, Verdin E, Greene WC (2001) Duration of nuclear NF-kB action is regulated by reversible acetylation. Science 293:1653–1657.

de Noronha CMC, Sherman MP, Lin HW, Cavrois MV, Moir RD, Goldman RD, Greene WC (2001) Dynamic disruptions in nuclear envelope architecture and integrity induced by HIV-1 Vpr. Science 294:1105–1108.

Geleziunas R, Xu W, Takeda K, Ichijo H, Greene WC (2001) HIV-1 Nef inhibits ASK1-dependent death signaling providing a potential mechanism for protecting the infected host cell. Nature 410:834–838.