Huang, Y., von Eckardstein, A., and Assmann, G. (1993) Cell-derived unesterified cholesterol cycles between different HDLs and LDL for its effective esterification in plasma. Arterioscler. Thromb. 13:445–458.

Huang, Y., von Eckardstein, A., Wu, S., Maeda, N., and Assmann, G. (1994) A plasma lipoprotein containing only apolipoprotein E and with gamma-mobility on electrophoresis releases cholesterol from cells. Proc. Natl. Acad. Sci. USA. 91:1834–1838.

Huang, Y., von Eckardstein, A., Wu, S., and Assmann, G. (1995) Effects of the apolipoprotein E-polymorphism on uptake and transfer of cell-derived cholesterol in plasma. J. Clin. Invest. 96:2693–2701.

Huang, Y., von Eckardstein, A., Wu, S., and Assmann, G. (1995) Cholesterol efflux, cholesterol esterification, and cholesterol ester transfer by LpA-I and LpAI/A-II in native plasma. Arterioscler. Thromb. Vasc. Biol. 15: 1412–1418.

Huang, Y., von Eckardstein, A., Wu, S., Langer, C., and Assmann, G. (1995) Generation of pre-b₁-HDL and conversion into a-HDL: Evidence for disturbed HDL conversion in Tangier Disease. Arterioscler. Thromb.Vasc. Biol. 15:1746–1754.

von Eckardstein, A., Huang, Y., Wu, S., Funke, H., Noseda, G., and Assmann, G. (1995) Reverse cholesterol transport in plasma of patients with different forms of familial HDL deficiency. Arterioscler. Thromb. Vasc. Biol. 15:691–703

von Eckardstein, A., Huang, Y., Wu, S., Saadat Sarmadi, A., Schwarz, S., Steinmetz, A., and Assmann, G. (1995) Lipoproteins containing apolipoprotein A-IV but not apolipoprotein A-I take up and esterify cell-derived cholesterol in plasma. Arterioscler. Thromb. Vasc. Biol. 15:1755–1763

von Eckardstein, A., Jauhiainen, M., Huang, Y., Metso, J., Langer, C., Pussinen, P., Wu, S., Ehnholm, C., and Assmann, G. (1996) Phospholipid transfer protein-mediated conversion of high density lipoproteins (HDL) generates preb₁-HDL. Biochiim. Biophys. Acta 1301:255–262.

Huang, Y., Schwendner, S.W., Rall, S.C. Jr., and Mahley, R.W. (1996) Hypolipidemic and hyperlipidemic phenotypes in transgenic mice expressing human apolipoprotein E2. J. Biol. Chem. 271:29146–29151.

Miccoli, R., Zhu, Y., Daum, U., Wessling, J., Huang, Y., Navalesi, R., Assmann, G., and von Eckardstein, A. (1997) A natural apolipoprotein A-I variant, apoA-I(L141R)pisa, interferes with the formation of a-high density lipoproteins (HDL) but not with the formation of preb₁-HDL and influences efflux of cholesterol into plasma. J. Lipid Res. 38:1242–1253

Huang, Y., Schwendner, S.W., Rall, S.C. Jr., and Mahley, R.W. (1997) Apolipoprotein E2 transgenic rabbits: Modulation of the type III hyperlipoproteinemic phenotype by estrogen and occurrence of spontaneous atherosclerosis. J. Biol. Chem. 272:22685–22694

Huang, Y., Rall, S.C., and Mahley, R.W. (1997) Genetic factors precipitating type III hyperlipoproteinemia in hypolipidemic transgenic mice expressing human apolipoprotein E2. Arterioscler. Thromb. Vasc. Biol. 17:2817–2824.

Huang, Y., von Eckardstein, A., Zhu, Y., Langer, C., Raabe, M., Wu, S., Seedorf, U., Maeda, N., and Assmann, G. (1997) Effects of genotype and diet on cholesterol efflux into plasma and lipoproteins of normal, apolipoprotein A-I-, and apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 17:2010–2019.

Fan, J., Ji, Z.S., Huang, Y., de Silva, H., Sanan, D., Mahley, R.W., Innerarity T.L., and Taylor, J.M. (1998) Increased expression of apolipoprotein E in transgenic rabbits results in reduced levels of very low density lipoproteins and an accumulation of low density lipoproteins in plasma. J. Clin. Invest. 101:2151–2164.

von Eckardstein, A., Huang, Y., Kastelein, J.J.P., Geisel, J., Real, J.T., Kuivenhoven, J.A., Miccoli, R., Noseda, G., and Assmann, G. (1998) Lipid-free apolipoprotein (apo) A-I is converted into alpha-migrating high density lipoproteins by lipoprotein-depleted plasma of normolipidemic donors and apo A-I-deficient patients but not of Tangier disease patients. Atherosclerosis 138:25–34.

Huang, Y., Liu, X.Q., Rall, S.C., and Mahley, R.W. (1998) Apolipoprotein E2 reduces low density lipoprotein cholesterol in transgenic mice by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. J. Biol. Chem. 273:17483–17490.

Huang, Y., Liu, X.Q., Rall, S.C., Taylor, J.M., von Eckardstein, A., Assmann, G., and Mahley, R.W. (1998) Overexpression and accumulation of apolipoprotein E as a cause of hypertriglyceridemia. J. Biol. Chem. 273:26388–26393.

Huang, Y., Ji, Z.S., Brecht W.J., Rall, S.C., Taylor, J.M., and Mahley, R.W. (1999) Overexpression of apolipoprotein E3 in transgenic rabbits causes combined hyperlipidemia by stimulating hepatic very low density lipoprotein (VLDL) production and impairing VLDL lipolysis. Arterioscler. Thromb. Vasc. Biol. 19:2952–2959.

Langer, C., Huang, Y., Cullen, P., Wiesenhutter, B., Mahley, R.W., Assmann, G., and von Eckardstein, A. (2000) Endogenous apolipoprotein E modulates cholesterol efflux and cholesterol ester hydrolysis mediated by high density lipoprotein 3 and lipid-free apolipoproteins in mouse peritoneal macrophages. J. Molecular Medicine 78:217–227.

Huang, Y., Liu, XQ., Wyss-Coray, T., Brecht, WJ., Sanan, DA., Mahley, RW. (2001) Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons. Proc. Natl. Acad. Sci. USA. 98:8838–8843.

Buttini, M., Yu, GQ., Shockley K., Huang, Y., Jones, B., Masliah, E., Mallory, M., Yeo, T., Longo, M., and Mucke, L. (2002) Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid b peptides but not on plaque formation. J. Neurosci. 22:10539–10548.

Ji, ZS., Miranda, RD., Newhouse, YM., Weisgraber, KH., Huang, Y., and Mahley, RW. (2002) Apolipoprotein E4 potentiates amyloid b peptide-induced lysosomal leakage and apoptosis in neuronal cells. J. Biol. Chem. 277:21821–21828.

Harris, FM., Walter, JB., Xu, Q., Tesseur I., Kekonius, L., Wyss-Coray, T., Fish, JD., Masliah, E., Hopkins, PC., Scearce-Levie, K., Weisgraber, KH., Mucke, L., Mahley, RW., and Huang, Y. (2003). Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer’s disease-like neurodegeneration and behavioral deficits in transgenic mice. Proc. Natl. Acad. Sci. USA. 100:10966–10971.

Harris, FM., Tesseur, T., Brecht, WJ., Xu, Q., Mullendorff, K., Chang, S., Wyss-Coray, T., Mahley, RW., and Huang, Y. (2004) Astroglial regulation of apolipoprotein E expression in neuronal cells: Implications for Alzheimer’s disease. J. Biol. Chem. 279:3862–3868.

Brecht,WJ., Harris, FM., Chang, S., Tesseur, I., Yu, GQ., Xu, Q., Wyss-Coray, T., Buttini, M., Mucke, L., Mahley, RW., and Huang, Y. (2004) Neuron-specific apolipoprotein E4 proteolysis is associated with increased tau phosphorylation in brains of transgenic mice. J. Neurosci. 24:2527–2534.

Xu, Q., Brecht, WJ., Weisgraber, KH., Mahley, RW., and Huang, Y. (2004) Apolipoprotein E4 domain interaction occurs in living neuronal cells as determined by fluorescence resonance energy transfer. J. Biol. Chem. 279:25511–25516.

Harris, FM., Brecht, WJ., Xu, Q., Mahley, RW., and Huang, Y. (2004) Increased tau phosphorylation in apolipoprotein E4 transgenic mice is associated with activation of extracellular signal-regulated kinase: Modulation by Zinc. J. Biol. Chem. 279:44795–44801.

Book Chapters Huang, Y. and Mahley RW. (1999) Apolipoprotein E and human disease. In Plasma Lipids and Their Role in Diseases.Editor, Philip J. Barter. p257–284.

Mahley, RW., and Huang, Y. (2003) Apolipoprotein E: structure and function in lipid metabolism and neurobiology. In The Molecular and Genetic Basis of Neurological Disease. Editors: Rosenberg, R.N., Prusiner, S.B., DiMauro, S., and Barchi, R.L., Nestler, E.J., Butterworth Heinemann, Newton, MA. p565–573.

Huang, Y. (2004) Transgenic and gene-targeted mouse models in hypoxic pulmonary hypertension research. In Hypoxic Pulmonary Vasoconstriction: Cellular and Molecular Mechanisms. Editor: Jason XJ. Yuan. p559–568.

Review Articles Published in Journal

von Eckardstein, A., Huang, Y., and Assmann, G. (1994) Physiological role and clinical relevance of high density lipoprotein subclasses. Curr. Opin. Lipidol. 5:404–416.

Assmann, G., Schulte, H., von Eckardstein, A., and Huang, Y. (1996) High density lipoprotein cholesterol as a predictor of coronary heart disease risk. The PROCAM experience and pathophysiological implication for reverse cholesterol transport. Atherosclerosis 124 (Suppl.):S11–S20.

von Eckardstein, A., Huang, Y., and Assmann, G. (1996) Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency. Z Gastroenterol. 34 (Suppl.) 3:143–144.

Mahley, R.W. and Huang, Y (1999) Apolipoprotein E: From atherosclerosis to Alzheimer’s disease and beyond. Curr. Opin. Lipidol. 10:207–217.

Mahley, R.W., Huang, Y., and Rall, S.C. (1999) Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): Questions, quandaries, and paradoxes. J. Lipid Res. 40:1933–1949.

Huang Y, Weisgraber KH, Mucke L, and Mahley RW. (2004) Apolipoprotein E: Diversity of cellular origins, structural and biophysical properties, and effects in Alzheimer’s disease. J. Mol. Neurosci. 23:187–202.

Review Articles Published in Proceedings

Assmann, G., von Eckardstein, A., Huang, Y., and Wu, S. (1995) A lipoprotein present in normal and HDL-deficient plasmas releases cholesterol from cells. Atherosclerosis X, Woodford, F.P. Editor. p. 662–665.

von Eckardstein, A., Huang, Y., and Assmann, G. (1996) Role of high density lipoprotein subclasses in reverse cholesterol transport. Proceedings of the Symposium on HDL-Deficiency and Atherosclerosis. Kluver Verlag, p. 17–23.

von Eckardstein, A., Huang, Y., Wu, S., and Assmann, G. (1996) Role of apoE for reverse cholesterol transport. Proceedings of the C.B. Pennington Conference on Nutrition, Genetics, and Heart Disease. Baton Rouge, Louisiana, USA. p. 189.

Abstracts Published in Journals

von Eckardstein, A., Huang, Y., Wu, S., Maeda, N., and Assmann, G. (1993) A soly apolipoprotein E containing plasma lipoprotein with electrophoretic gamma-mobility takes up cellular cholesterol. Circulation 88 (Suppl. ) I–269.

von Eckardstein, A., Huang, Y., Wu, S., Noseda, G., and Assmann, G. (1994) Uptake, transfer, and esterification of cell-derived cholesterol in plasma of patients with familial HDL-deficiency. Atherosclerosis 109:232.

Huang, Y., von Eckardstein, A., Wu, S. and Assmann, G. (1994) Generation and conversion of preb₁-LpA-I in vitro: Evidence for the presence in human plasma of a factor converting preb₁-LpA-I into a-LpA-I. Xth International Symposium on Atherosclerosis. Atherosclerosis 109:232.

Assmann, G., Huang, Y., Wu, S., and von Eckardstein, A. (1994) A lipoprotein containing only apoE present in normal and HDL-deficient plasmas releases cholesterol from cells. Atherosclerosis 109:334.

von Eckardstein, A., Huang, Y., Raabe, M., Langer, C., Wu, S., Seedorf, Udo., Maeda, N., and Assmann, G. (1995) Reverse cholesterol transport in normal, apolipoprotein A-I, and apolipoprotein E-deficient mice. Circulation 92 (Suppl.):I–557

von Eckardstein, A., Huang, Y., Steinmetz, A., and Assmann, G. (1995) Apolipoprotein A-IV containing high density lipoproteins take up and esterify cell derived cholesterol in plasma. Circulation 92 (Suppl.):I–557

Huang, Y., Schwendner, S.W., Rall, S.C., and Mahley, R.W. (1996) Type III hyperlipoproteinemic transgenic rabbits with defective human apolipoprotein E. Circulation 94 (Suppl. ) I–518

Huang, Y., Liu, X.Q., Rall, S.C., and Mahley, R.W. (1997) Hypo-low density lipoprotein cholesterol effect of apolipoprotein E2 in transgenic mice is caused by impairing lipoprotein lipase-mediated lipolysis of triglyceride-rich lipoproteins. Circulation 96 (Suppl.) I–39.

Huang, Y., Brecht, W.J., Liu, X.Q., Rall, S.C., and Mahley, R.W. (1999) Apolipoprotein E promoter —219T/G polymorphism: A powerful predictor of plasma lipid levels in humans. Circulation 100 (Suppl.) I–197.

Huang, Y., Brecht, W.J., Liu, X.Q., Rall, S.C., and Mahley, R.W. (1999) Overexpression of apolipoprotein E stimulates synthesis and mobilization of triglycerides to the endoplasmic reticulum in rat hepatoma cells (McA-RH7777). Circulation 100: I–686.

Huang, Y., Liu, X.Q., Rall, S.C., and Mahley, R.W. (2000) Pathogenesis of type III hyperlipoproteinemia: Lessons from transgenic animal studies. Atherosclerosis 150 (Suppl.1) S6.

Huang, Y., Brecht, W.J., Liu, X.Q., Wang, Y., Taylor, J.M., Rall, S.C., and Mahley, R.W. (2000) Apolipoprotein (apo) E modulates hepatic very low density lipoprotein (VLDL) assembly and secretion. Atherosclerosis 151(1):158.

Huang, Y., Liu, X.Q., and Mahley, R.W. (2000) Differential effects of cytosolic apolipoprotein (apo) E3 and apoE4 on neurite outgrowth and the cytoskeleton. Neurobiology of Aging 21(1S):S216.

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