DGAT-1 POLYMORPHISM ASSOCIATED WITH OBESITY

Background: Gladstone scientists discovered polymorphisms in the human DGAT1 gene, a gene that encodes an enzyme involved in the synthesis of fat (triglycerol). One of the polymorphisms, a common variation in the promoter region of the human DGAT1 gene, has been correlated with body mass index, blood pressure, and HDL cholesterol levels in Turkish women. This common variation in the DNA may be useful in screening for propensity to conditions such as obesity or diabetes.

Patent Status: US Patent 6,444,427 i

Gladstone Contact: Caryl Cachola
Telephone: 415-734-2082

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