- Kwon HS, Brent MM, Getachew R, Jayakumar P,Chen LF, Schnoelzer M, McBurney MW,Marmorstein
R, Greene WC, Ott M. (2008) Human immunodeficiency
virus type 1 Tat protein inhibits the SIRT1
deacetylase and induces T-cell hyperactivation. Cell Host Microbe. In Press.
- Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J and Ott M (2007) Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 1:e151.
- Nieters A, Kallinowski B, Brennan P, Ott M, Maynadie M, Benavente Y, Foretova L, Cocco PL, Staines A, Voranen M, Whitby D, Boffetta P, Becker N and de SanJose S.(2006) Hepatitis C and risk of lymphoma: Results of the European multicenter case-control study EPILYMPH Gastroenterology. 131:1879-1886.
- Mahmoudi T, Parra M, Vries GJR, Kauder SE, Verrijzer PC, Ott M, Verdin E (2006) The SWI/SNF Chromatin-remodling Complex Is a Cofactor for Tat Transcription of the HIV Promoter. J. Biol. Chem.. 281:19960-19968.
- Hetzer C, Dormeyer W, Scholzer M, Ott M (2005) Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect. . 7:1364-1369.
- Dormeyer W, Ott M, Schnolzer M (2005) Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Methods 36:376-382
- Dormeyer W, Ott M, Scholzer M (2005) Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics. 4:1226-39
- Pagans, S., Pedal, A., North, BJ., Kaehlcke, K., Marshall, BL., Corr, A., Hetzer-Egger, C., Heinklein, P., Frye, R., McBurney, MW., Hruby, H., Jung, M., Verdin, E., Ott, M SIRT1 Regulates HIV Transcription via Tat Deacetylation. PLoS Biology. 2005, 3(2):e41.
- Schwer, B., Ren, S., Pietschmann, T., Kartenbeck, J., Kaehlcke, K., Bartenschlager, R., Yen, TS., Ott, M. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004, 78(15):7958-68.
- Kirk, GD., de Sanjose, S., Ott, M. Impact of race on the association between diabetes and HCV. Am J Gastroenterol. 2004, 99(3):564
- Ott, M., Dorr, A., Hetzer-Egger, C., Kaehlcke, K., Schnoelzer, M., Henklein, P., Cole, P., Zhou, M., Verdin, E. Tat Acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found. Symp 2004, 259:182-93; discussion 193-6, 223-5. Review
- Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., Stilper, A., Willbold, D., D’Aloja, P., Sixt, M., Kolanus, J., Ott, M., Kolanus, W., Schuler, G., Baur, A. HIV-1 Nef Mimics an Integrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane. Mol. Cell, 2004, 13:179-190.
- Kaehlcke, K., Dorr, A., Hetzer-Egger, C., Henklein, P., Schnoelzer, M., Loret, E., Cole, P., Verdin, E., Ott, M.,
Acetylation of Tat defines a Cyclin T1-independent step in HIV Transactivation. Mol. Cell, 2003, 12:167-176.
- Dormeyer, W., Dorr, A., Ott, M., Schnoelzer, M. Acetylation of the HIV Tat protein: an in-vitro study. Anal. Bioanal. Chem. 2003, 376:994-1005.
- Fritzsching, B., Schwer, B., Kartenbeck, J., Pedal, A., Horejsi, V., Ott, M. Release and intercellular transfer of cell surface CD81 via microparticles. J. Immunol., 2002, 169:5531–5537.
- Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol., 2002, 158:647–657.
- Dorr, A., Kiermer, V., Pedal, A., Rackwitz, H.-R., Henklein, P., Schubert, U., Zhou, M.-M., Verdin, E., Ott, M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J., 2002, 21: 1–9.
- Mujtaba, S., He, Y., Zeng, L., Farooq A., Carlson, J., Ott, M., Verdin, E., Zhou, M.-M. Structural
basis of lysine-acetylated HIV-1 Tat recognition by P/CAF bromodomain. Mol.
Cell, 2002, 9: 575–586.
- Koller, H., Schaal, H., Freund, M., Garrido, S.,R., von Giesen, H.-J., Ott, M., Rosenbaum, C., Arendt, G. HIV-1 protein Tat reduces glutamate induced intracellular Ca2+ increase in cultured cortical astrocytes.
Eur. J. Neurosci., 2001, 14: 1793–1799.
- Ott, M., Schnoelzer, M., Garnica, J., Fischle, W., Emiliani, S., Rackwitz, H.R., Verdin, E. Acetylation of HIV-1 Tat protein is important for its transcriptional activity. Curr. Biol., 1999, 9:1489–1492.
- Ott, M., Lovett, J.L., Mueller L., Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein
is mediated through NF-kB factors. J. Immunol., 1998, 160:
2872–2880.
- Emiliani S., Fischle W., Ott, M., Van Lint, C., Amella, C.A., Verdin E. Mutations in the Tat gene are responsible for HIV-1 post-integration latency in the U1 cell line. J. Virol., 1998, 72: 1666–1670.
- Ott, M., Seidl, C., Westhoff, U., Stecker, K., Seifried E., Fischer, P.-A., Grosse-Wilde, H. Soluble HLA class I and II antigens in patients with multiple sclerosis. Tissue Antigens, 1998, 51: 301–304.
- Ott,M., Emiliani S., Van Lint C., Herbein
G., Lovett J., Chirmule N., McCloskey T., Pahwa S., Verdin E. Immune hyperactivation of HIV-1 infected T cells mediated by Tat and the CD28 pathway. Science, 1997: 275: 1481–1485.
- McCloskey T., Ott,M., Tribble E, Khan S., Teichberg S., Paul M., Pahwa S., Verdin E., Chirmule N.
Dual role of HIV Tat in regulation of apoptosis in T cells. J. Immunol., 1997, 158: 1014–1019.
- Van Lint C., Emiliani S., Ott,M., Verdin E. Transcriptional activation and chromatin remodelling of the HIV-1 promoter in response to histone acetylation. EMBO J., 1996, 15: 11112–11120.
- Emiliani S.,Van Lint C., Fischle W., Paras P.Jr., Ott,M., Brady J., Verdin E. A point mutation in the
HIV-1 Tat responsive element is associated with post-integration latency.
Proc. Natl. Acad. Sci. USA, 1996, 93:
6377–6381.
- Ott, M., Demisch L., Engelhard W., Fischer P.-A. Interleukin-2, soluble interleukin-2-receptor, neopterin, L-tryptophan and b2-microglobulin levels in the CSF and serum of patients with relapsing-remitting and chronic progressive multiple sclerosis. J. Neurol., 1993, 241: 108–114.
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