Melanie Ott, M.D., Ph.D. -

Publications

Ott M, Verdin E. (2010) HAT trick: p300, small molecule, inhibitor.
Chem Biol. 17(5):417-8.
Pagans S, Sakane N, Ott M. (2010) Characterization of the HIV Tat transactivator using novel methyl-lysine specific antibodies.
Methods 2010 Jul 6. [Epub ahead of print]
Herker E, Harris C, Kaehlcke K, Farese RV Jr, Ott M. (2010) Hepatitis C Virus Particle Formation requires Diacylglycerol Acyltransferase 1 (DGAT1).
Nat Med In Press
Cho S, Schroeder S and Ott M (2010) CYCLINg through transcription Posttranslational modifications of P-TEFb regulate transcription elongation.
Cell Cycle 9(9):1697-705.
Pagans S, Kauder S, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel R, Verdin E, Schnolzer M and Ott M. (2010) The cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat and enhances HIV transcription.
Cell Host Microb 7(3):234-244.
Cho S, Schroeder S, Kaehlcke K, Pedal A, Kwon H-S, Herker E, Schnoelzer M and Ott M. (2009) Acetylation of the cyclinT subunit activates the positive transcription elongation factor b through dissociation of the Hexim1 inhibitor and 7SK small nuclear RNA.
EMBO J. 28(10):1407-17
Pagans S, Kauder S, Kaehlcke K, Sakane N, Schroeder S, Dormeyer W, Trievel R, Verdin E, Schnolzer M and Ott M. (2010) The cellular lysine methyltransferase Set7/9-KMT7 binds HIV-1 TAR RNA, monomethylates the viral transactivator Tat and enhances HIV transcription.
Cell Host Microbe. 7(3):234-244
Nakamura K, Nemani VM, Wallender EK, Kaehlcke K, Ott M, Edwards RH. (2008) Optical reporters for the conformation of alpha-synuclein reveal a specific interaction with mitochondria.
J Neurosci.19;28(47):12305-17..
Kwon HS and Ott M. (2008) The Ups and Downs of SIRT1. Trends Biochem Sci. Sep 18. Epub.
Kwon HS, Brent MM, Getachew R, Jayakumar P,Chen LF, Schnoelzer M, McBurney MW,Marmorstein R, Greene WC, Ott M. (2008) Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T-cell hyperactivation. Cell Host Microbe3(3):158-67.
Hetzer C, Bisgrove D, Cohen MS, Pedal A, Kaehlcke K, Speyerer A, Bartscherer K, Taunton J and Ott M (2007) Recruitment and activation of RSK2 by HIV-1 Tat. PLoS One. 1:e151.
Nieters A, Kallinowski B, Brennan P, Ott M, Maynadie M, Benavente Y, Foretova L, Cocco PL, Staines A, Voranen M, Whitby D, Boffetta P, Becker N and de SanJose S.(2006) Hepatitis C and risk of lymphoma: Results of the European multicenter case-control study EPILYMPH Gastroenterology. 131:1879-1886.
Mahmoudi T, Parra M, Vries GJR, Kauder SE, Verrijzer PC, Ott M, Verdin E (2006) The SWI/SNF Chromatin-remodling Complex Is a Cofactor for Tat Transcription of the HIV Promoter. J. Biol. Chem.. 281:19960-19968.
Hetzer C, Dormeyer W, Scholzer M, Ott M (2005) Decoding Tat: the biology of HIV Tat posttranslational modifications. Microbes Infect. . 7:1364-1369.
Dormeyer W, Ott M, Schnolzer M (2005) Analysis of p300 acetyltransferase substrate specificity by MALDI TOF mass spectrometry. Methods 36:376-382
Dormeyer W, Ott M, Scholzer M (2005) Probing lysine acetylation in proteins: strategies, limitations, and pitfalls of in vitro acetyltransferase assays. Mol Cell Proteomics. 4:1226-39
Pagans, S., Pedal, A., North, BJ., Kaehlcke, K., Marshall, BL., Corr, A., Hetzer-Egger, C., Heinklein, P., Frye, R., McBurney, MW., Hruby, H., Jung, M., Verdin, E., Ott, M SIRT1 Regulates HIV Transcription via Tat Deacetylation. PLoS Biology. 2005, 3(2):e41.
Schwer, B., Ren, S., Pietschmann, T., Kartenbeck, J., Kaehlcke, K., Bartenschlager, R., Yen, TS., Ott, M. Targeting of hepatitis C virus core protein to mitochondria through a novel C-terminal localization motif. J Virol. 2004, 78(15):7958-68.
Kirk, GD., de Sanjose, S., Ott, M. Impact of race on the association between diabetes and HCV. Am J Gastroenterol. 2004, 99(3):564
Ott, M., Dorr, A., Hetzer-Egger, C., Kaehlcke, K., Schnoelzer, M., Henklein, P., Cole, P., Zhou, M., Verdin, E. Tat Acetylation: a regulatory switch between early and late phases in HIV transcription elongation. Novartis Found. Symp 2004, 259:182-93; discussion 193-6, 223-5. Review
Witte, V., Laffert, B., Rosorius, O., Lischka, P., Blume, K., Galler, G., Stilper, A., Willbold, D., D’Aloja, P., Sixt, M., Kolanus, J., Ott, M., Kolanus, W., Schuler, G., Baur, A. HIV-1 Nef Mimics an Integrin Receptor Signal that Recruits the Polycomb Group Protein Eed to the Plasma Membrane. Mol. Cell, 2004, 13:179-190.
Kaehlcke, K., Dorr, A., Hetzer-Egger, C., Henklein, P., Schnoelzer, M., Loret, E., Cole, P., Verdin, E., Ott, M., Acetylation of Tat defines a Cyclin T1-independent step in HIV Transactivation. Mol. Cell, 2003, 12:167-176.
Dormeyer, W., Dorr, A., Ott, M., Schnoelzer, M. Acetylation of the HIV Tat protein: an in-vitro study. Anal. Bioanal. Chem. 2003, 376:994-1005.
Fritzsching, B., Schwer, B., Kartenbeck, J., Pedal, A., Horejsi, V., Ott, M. Release and intercellular transfer of cell surface CD81 via microparticles. J. Immunol., 2002, 169:5531–5537.
Schwer B, North BJ, Frye RA, Ott M, Verdin E. The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J. Cell Biol., 2002, 158:647–657.
Dorr, A., Kiermer, V., Pedal, A., Rackwitz, H.-R., Henklein, P., Schubert, U., Zhou, M.-M., Verdin, E., Ott, M. Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain. EMBO J., 2002, 21: 1–9.
Mujtaba, S., He, Y., Zeng, L., Farooq A., Carlson, J., Ott, M., Verdin, E., Zhou, M.-M. Structural basis of lysine-acetylated HIV-1 Tat recognition by P/CAF bromodomain. Mol. Cell, 2002, 9: 575–586.
Koller, H., Schaal, H., Freund, M., Garrido, S.,R., von Giesen, H.-J., Ott, M., Rosenbaum, C., Arendt, G. HIV-1 protein Tat reduces glutamate induced intracellular Ca²⁺increase in cultured cortical astrocytes. Eur. J. Neurosci., 2001, 14: 1793–1799.
Ott, M., Schnoelzer, M., Garnica, J., Fischle, W., Emiliani, S., Rackwitz, H.R., Verdin, E. Acetylation of HIV-1 Tat protein is important for its transcriptional activity. Curr. Biol., 1999, 9:1489–1492.
Ott, M., Lovett, J.L., Mueller L., Verdin E. Superinduction of IL-8 in T cells by HIV-1 Tat protein is mediated through NF-kB factors. J. Immunol., 1998, 160: 2872–2880.
Emiliani S., Fischle W., Ott, M., Van Lint, C., Amella, C.A., Verdin E. Mutations in the Tat gene are responsible for HIV-1 post-integration latency in the U1 cell line. J. Virol., 1998, 72: 1666–1670.
Ott, M., Seidl, C., Westhoff, U., Stecker, K., Seifried E., Fischer, P.-A., Grosse-Wilde, H. Soluble HLA class I and II antigens in patients with multiple sclerosis. Tissue Antigens, 1998, 51: 301–304.
Ott,M., Emiliani S., Van Lint C., Herbein G., Lovett J., Chirmule N., McCloskey T., Pahwa S., Verdin E. Immune hyperactivation of HIV-1 infected T cells mediated by Tat and the CD28 pathway. Science, 1997: 275: 1481–1485.
McCloskey T., Ott,M., Tribble E, Khan S., Teichberg S., Paul M., Pahwa S., Verdin E., Chirmule N. Dual role of HIV Tat in regulation of apoptosis in T cells. J. Immunol., 1997, 158: 1014–1019.
Van Lint C., Emiliani S., Ott,M., Verdin E. Transcriptional activation and chromatin remodelling of the HIV-1 promoter in response to histone acetylation. EMBO J., 1996, 15: 11112–11120.
Emiliani S.,Van Lint C., Fischle W., Paras P.Jr., Ott,M., Brady J., Verdin E. A point mutation in the HIV-1 Tat responsive element is associated with post-integration latency. Proc. Natl. Acad. Sci. USA, 1996, 93: 6377–6381.
Ott, M., Demisch L., Engelhard W., Fischer P.-A. Interleukin-2, soluble interleukin-2-receptor, neopterin, L-tryptophan and b₂-microglobulin levels in the CSF and serum of patients with relapsing-remitting and chronic progressive multiple sclerosis. J. Neurol., 1993, 241: 108–114.

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