• The J. David Gladstone Institutes is an independent, not-for-profit biomedical research institution affiliated with the University of California, San Francisco (UCSF), devoted to research into cardiovascular disease, HIV/AIDS, and Alzheimer’s disease and other neurological disorders

Mission and Focus

• Our mission: to contribute to the health and welfare of humankind through research into the causes and prevention of cardiovascular disease, HIV and AIDS, and Alzheimer’s disease and other neurodegenerative disorders
• Our focus: to conduct basic research for a better understanding of the fundamental biological processes underlying these maladies
• Our vision: to reduce the number of people afflicted with these debilitating illnesses, resulting in a substantial reduction in the social, emotional and financial costs of these disorders

Scientific Objectives and Accomplishments

• Research is organized into three key areas:

The Gladstone Institute of Cardiovascular Disease is dedicated to reducing the death toll caused by cardiovascular disease. Institute researchers focus on the role of embryonic processes that might be leveraged for cardiac stem cell biology, as well as congenital and acquired heart diseases; genetic modification to gain control of key molecules involved in stem cell development; genetics of heart disease in humans; the role of lipids and lipoproteins in heart disease, including macrophage biology and obesity research; the potential role of the enzyme DGAT1 in resisting diet-induced obesity; and inflammatory processes in atherosclerosis.

The Gladstone Institute of Virology and Immunology is dedicated to conquering major problems involving deadly viruses and the human immune system, with an emphasis on HIV and AIDS. Investigators conduct a broad range of investigations, including fundamental studies of how HIV grows, evolves, and induces disease; the interplay of HIV with various components of the immune system, including cytotoxic T lymphocytes, NKT cells and T-regulatory lymphocytes; the evaluation of new anti-viral drugs; and the use of cytokines and hormones to help rebuild the immune system

The Gladstone Institute of Neurological Disease is dedicated to the study of the healthy and diseased nervous system. Its researchers are investigating such topics as the mechanisms by which abnormally folded proteins cause neurodegenerative disorders, including Alzheimer's, Parkinson's, and Huntington's disease; the development and preclinical evaluation of novel treatments for these conditions; the functions and pathogenic roles of amyloid proteins and apolipoprotein E; brain inflammation; and mechanisms of neural repair

Organizational Structure

• An independent, not-for-profit medical research organization under IRS Sections 501(c)(3) and 170(b)(1)(A)(iii)
• The Gladstone Trust endowment was established in 1971, as part of the will of real estate developer J. David Gladstone (1910-1971)
• Supported primarily by National Institutes of Health grants, as well as the Gladstone Trust
• Corporate offices are based in Irvine, California. Managed by three trustees
• The first Gladstone institute, the Gladstone Institute of Cardiovascular Disease, was established in 1979, followed by the Gladstone Institute of Virology and Immunology in 1993 and the Gladstone Institute of Neurological Disease in 1998
• Separate scientific advisory boards for each institute are comprised of a total of 20 preeminent scientists from the U.S. and the U.K.
• All Gladstone investigators hold UCSF faculty appointments appointments
• Research environment is collegial, group oriented, and interdisciplinary

Financial

• Annual budget of $52 million (2006)
• Number of employees, January, 2006: 358
• Projected 2006 Sources of funding:

  NIH	59%   $31 million
  Gladstone Trust and fundraising	32%   $16 million
  Other awards (including the American Heart Association, Alzheimer's Association, and various organizations supporting AIDS research) & income	9%     $5 million

• Ongoing commitment to commercialize new technologies developed by scientific staff

Key administrators

• Robert W. Mahley, MD, PhD, President, The J. David Gladstone Institutes; Senior Investigator, Gladstone Institute of Cardiovascular Disease; Senior Investigator, Gladstone Institute of Neurological Disease; Professor of pathology and medicine, UCSF
• Deepak Srivastava, MD, Director, Gladstone Institute of Cardiovascular Disease; Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology; Professor of pediatrics, UCSF
• Warner C. Greene, MD, PhD, Director and Senior Investigator, Nick and Sue Hellmann Distinguished Professor of Translational Medicine, Gladstone Institute of Virology and Immunology; Professor of Medicine, Microbiology and Immunology, UCSF
• Lennart Mucke, MD, Director, Gladstone Institute of Neurological Disease; Joseph B. Martin Distinguished Professor in Neuroscience, UCSF
• Karl Weisgraber, PhD, Deputy Director and Senior Investigator, Gladstone Institute of Cardiovascular Disease; Senior Investigator, Gladstone Institute of Neurological Disease; Adjunct Professor of pathology, UCSF
• Eric Verdin, MD, Associate Director and Senior Investigator, Gladstone Institute of Virology and Immunology; Professor of medicine, UCSF
• Dan Oshiro, MS, Vice President for Administrative Affairs

Physical Setting

• Located in a new, six-story, ~200,000-s.f. headquarters building at the center of the Mission Bay redevelopment project, which promises to become one of the West Coast's largest concentrations of organizations involved in biomedical discovery, biotechnology, and advanced health care services
• Site is adjacent to UCSF's major new research campus and, ultimately, will be surrounded by a wide spectrum of pharmaceutical and biotechnology companies

Contact

Dan Oshiro
The J. David Gladstone Institutes
1650 Owens Street
San Francisco, CA 94158
415-734-2019
FAX 415-355-0826