REGENERATIVE MEDICINE AT GLADSTONE   For decades, physicians and scientists have dreamed of replacing or repairing damaged organs and tissues to heal the sick. Recent remarkable advances in developmental biology and stem cells—cells that can develop into any cell type—have brought this possibility into the realm of reality. The dramatic discovery by Shinya Yamanaka of a method to “reprogram” adult cells into cells resembling stem cells has accelerated research into regenerative medicine. At Gladstone, researchers focus on using these technologies to better understand disease, to bring new therapies to the clinic, and to train the next generation of biomedical scientists.   WHAT ARE STEM CELLS? Embryonic stem (ES) and induced pluripotent stem (iPS) cells have two amazing properties. They can reproduce themselves indefinitely, and they can develop into any cell type in the body. Scientists see ES and iPS cells as valuable tools for studying disease and potentially for repairing damaged organs.   REVERSE ENGINEERING: Stem Cells from Skin Cells Vast potential seen for iPS cells     STEM CELL RESEARCH TAKES OFF Rapid advances have reshaped stem cell research     ANOTHER STEP FORWARD for iPS CELLS New discovery is just the beginning The award winning video, written and produced by Mark White, Kathy Ivey and Josh Arnold of The Gladstone Institute of Cardiovascular Disease.   WHAT'S NEXT IN REGENERATIVE MEDICINE? The discovery of iPS cells has spurred research into regenerative medicine. What are the next steps to bring us closer to clinical applications of stem cells? Gladstone researchers are focusing on exactly that.   GROWING HEARTS: Getting Started Key transcription factors identified   MICROMANAGING DEVELOPMENT microRNAs open up exciting new level of genetic control   PREDICTING the FUTURE New discoveries bring new challenges in stem cell research   DIVIDE and EXPAND A new view of early heart development   STEM CELL NEWS Shinya Yamanaka Wins 2009 Lasker Award   RESEARCH in VIEW Benoit Bruneau Bruce Conklin Fen-Biao Gao Warner Greene Yadong Huang Deepak Srivastava Eric Verdin Shinya Yamanaka   TRAINING Nearly two-thirds of the laboratories at Gladstone are engaged in some aspect of stem cell research. The Gladstone CIRM Scholars program is the centerpiece of our stem cell research efforts.   PARTNERS in RESEARCH Gladstone has established several key partnerships for its research on regenerative medicine. These collaborations will speed research into this exciting new technology. CIRM iPierian iPSOntario