- Regenerative Medicine at Gladstone -

Research at Gladstone

Stem cell research at Gladstone involves 18 of 25 laboratories. Led by iPS discoverer Shinya Yamanaka, the research includes studies of how to improve the iPS technology and how to use this powerful tool to explore development and disease.

Detailed here are some of the exciting and extraordinarily promising research directions in regenerative medicine currently underway in the laboratories of Gladstone's world renown investigative faculty.

Living heart cells differentiated from iPS cells

GLADSTONE RESEARCHERS in REGENERATIVE MEDICINE


		BENOIT BRUNEAU, PhD Induction of Cardiogenesis in Pluripotent Cells Via Chromatin Remodeling Factors

BRUCE CONKLIN, MD

Induced Pluripotent Stem Cells for Cardiovascular Diagnostics

FEN-BIAO GAO, PhD

Establishment of Frontotermporal Dementia Patient-Specific Induced Pluripotent Stem (iPS) Cell Lines with Defined Genetic Mutations
MicroRNAs in Human Stem Cell Differentiation and Mental Disorders

WARNER GREENE, MD, PhD

Maximizing the Safety of Induced Pluripotent Stem Cells as an Infusion Therapy: Limiting the mutagenic Threat of Retroelement Retrotransposition during IPSC Generation, Expansion, and Differentiation
The APOBEC3 Gene Family as Guardians of Genome Stability in Human Embryonic Stem Cells

YADONG HUANG, MD, PhD

Defining the Isoform-specfific Effects of Apolipoprotein E on the Development of IPS Cells into Functional Neurons in Vitro and in Vivo

DEEPAK SRIVASTAVA, MD

Pluripotent Stem Cell?Based Therapy for Heart Disease
CIRM Shared Human Embryonic Stem Cell Core Laboratory
MicroRNA Regulation of Cardiomyocyte Differentiation from Human Embryonic Stem Cells

ERIC VERDIN, MD

Role of HDAC in Human Stem Cells Pluripotentiality and Differentiation

SHINYA YAMANAKA, MD, PhD

Dr. Yamanaka discovered that fully differentiated adult mouse and human cells can be reprogrammed to become undifferentiated, pluripotent cells by expressing only four transcription factors. He called these cells induced pluripotent cells (iPS cells).